Using Existing Databases to Answer Research Questions in Aging Stephen B. Kritchevsky, PhD March 3, 2015.

Slides:



Advertisements
Similar presentations
Using Prognosis to Make Screening Decisions Elizabeth Eckstrom, MD, MPH Oregon Health & Science University Hollis Day, MD, MS University of Pittsburgh.
Advertisements

Physical Activity and Bone Health during Childhood and Adolescence: Critical Periods for the Prevention of Osteoporosis Suggested Links (click below)
Results from the Health, Aging, and Body Composition Study Nicole Vogelzangs 1, Brenda Penninx 1, Aartjan Beekman 1, Gretchen Brenes 2, Anne Newman 3,
Muscle mass and strength  Muscle mass is the primary determinant of strength –Obese individuals have higher lean mass therefore are stronger than thinner.
Sedentary Lifestyle Are We So Lazy That It’s Killing Us?
Resilient Aging Gregg Warshaw, MD University of Cincinnati OAGE Conference Dayton, Ohio March 28, 2014.
Meet the Author Webcast Public Health Reports Meet the Author Webcast Socioeconomic Status and Risk of Diabetes-Related Morality in the United States With.
Preventing Older Adult Falls: Understanding Risk Factors & Best Practices Healthy Aging Partnership May 26, 2009 Sally York MN, RNC NorthWest Orthopaedic.
Body Image and Weight Status among African American and Caucasian Overweight Postpartum Women Participating in a Weight Loss Intervention Lori Carter-Edwards,
CDC Resources and Tools for Aging Services Professionals Angela Johnson Deokar, MPH, CHES, CPH Public Health Advisor, Healthy Aging Program Centers for.
Institute of Exercise Physiology & Wellness University of Central Florida Muscular Adaptations to Strength Training ExeRcise in Seniors Maren Fragala,
We’re ready to TEST our Research Questions! In science, how do we usually test a hypothesis?
Copyright © 2013 by Mosby, an imprint of Elsevier Inc. Importance of Health Assessment DSN Kevin Dobi, MS, APRN.
Presentation Package for Concepts of Physical Fitness 14e
HIV INTERVENTION FOR PROVIDERS (HIP) Principal Investigators:  Carol Dawson Rose, RN, Ph.D. and Grant Colfax, MD. Co-Investigators:  Cynthia Gomez, Ph.D.,
October 6, 2005 Dennis Haeckl The Health And Cost Consequences Of Obesity Among The Future Elderly D. Lakdawalla, D. Goldman, B. Shang Health Affairs September.
A Diverse & Aging California Health Issues Steven P. Wallace, Ph.D. Professor, UCLA School of Public Health Assoc. Dir., UCLA Center for Health Policy.
Cohort Studies.
EPIDEMIOLOGY OF AGING DEFINITION AND INTRODUCTION TO RESEARCH IN THIS AREA PRESENTATION OF AGING AND PHYSICAL ACTIVITY AS AN EXEMPLAR FOR RESEARCH IN THE.
Department of Health and Human Services, Centers for Disease Control and Prevention Older Adult Falls from a National Perspective Judy A. Stevens, Ph.D.
Body Mass Index, Weight Change and Death in an Older Hypertensive Population: The SHEP Study Grant W Somes Stephen B Kritchevsky Marco Pahor Ronald I Shorr.
Prevention Guidelines and the Risk of Nursing Home Admission Elmira Valiyeva, Ph.D., Rutgers Louise Russell, Ph.D., Rutgers Jane Miller, Ph.D., Rutgers.
Future Research Agenda for MCH: Children with Special Health Care Needs November 10, 2004 Washington, DC Deborah Allen, ScD Boston University School of.
Aging and Obesity Claire Zizza Tenth Annual Diabetes and Obesity Conference April 19, 2011.
Obesity among Hispanics - a brief demographic account Rodolfo Valdez, Ph.D., M. Sc. Division of Diabetes Translation Centers for Disease Control and Prevention.
© The Hygenic Corporation The Active Aging Toolkit For Healthcare Providers Promoting Physical Activity in Older Adults.
The State of Obesity Better Policies for a Healthier America Jack Rayburn, MPH Senior Government Relations Manager Human Services and Public Safety Policy.
Chapter 9 What Exercise Will Do for You. A bear, however hard he tries, grows tubby without exercise. Pooh’s Little Instruction Book.
9/17/ Access WHI: Proposing Analyses and Ancillary Studies Andrea Z. LaCroix, PhD Professor of Epidemiology and Co-PI WHI Clinical Coordinating Center.
Epidemiology of CVD in the Elderly Karen P. Alexander MD Duke University Medical Center Duke Clinical Research Institute Disclosures: (1) Minor Research:
Deanna Cromer Grade Level 10th. Total Fitness Five components of Total Fitness  Cardiovascular fitness  Muscular Strength  Muscular Endurance  Body.
Basma Y. Kentab MSc.. 1. Define ambulatory care 2. Describe the value of ambulatory care practices 3. Explore pharmacy services in some ambulatory care.
Designing the Age Friendly Worksite1 Module 5: Focus on the Individual Health Promotion & Disease Prevention.
Data Access Pilot Project (DAPP) Mei-Hua Huang, DrPH Sharon Stein Merkin, PhD Core Directors: Gail Greendale, MD, Arun Karlamangla, PhD, MD Teresa Seema,
Michelle Koford Summer Topics Discussed Background Purpose Research Questions Methods Participants Procedures Instrumentation Analysis.
LESSON 9.5: TYPES OF STUDIES Module 9: Epidemiology Obj. 9.5: Compare & contrast different types of epidemiological studies.
1 Clinical Investigation and Outcomes Research Research Using Existing Databases Marcia A. Testa, MPH, PhD Department of Biostatistics Harvard School of.
Type 2 Diabetes in the Elderly: Options for Treatment David Kelley.
National Heart, Lung, and Blood Institute Women’s Health Initiative Branch Jacques Rossouw, MD Chief, WHI Branch Program for Prevention and Population.
Chapter 11 Special Topics in Adult Nutrition: Physical Activity & Weight Management Stella Lucia Volpe PhD,RD,LDN,FACSM.
The Obesity/Diabetes Epidemic: Perspectives, Consequences, Prevention, Treatment Stan Schwartz MD, FACP, FACE Private Practice, Ardmore Obesity Program.
1 Overview of the National Long Term Care Survey (NLTCS) Conference on Chinese Healthy Aging and Socioeconomic Development Durham, NC August, 2004 Nicholas.
Poverty and Health Jennifer Madans, Kimberly Lochner, and Diane Makuc National Center for Health Statistics Centers for Disease Control and Prevention.
Questionnaires and Interviews Steven R. Cummings, MD Director, S.F. Coordinating Center.
THE COMMONWEALTH FUND Source: McCarthy and Leatherman, Performance Snapshots, Percentage of Community-Dwelling Adults Ages.
Strategies for Seniors and Sports Paul Stonebrook Health Improvement and Prevention Department of Health.
Rosemarie Hirsch M.D., M.P.H.
Cardiovascular Disease Healthy Kansans 2010 Steering Committee Meeting April 22, 2005.
1Concepts of Physical Fitness 12e Presentation Package for Concepts of Physical Fitness 12e Section II: Concept 04 The Health Benefits of Physical Activity.
The National Health and Nutrition Examination Survey U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention National Center.
CREATE-A-GAME PE 1. Game, game, game, game, game….. You will be in groups of 4-5 and we will work on this project during class. (1) design, (2) trial,
F UNCTIONAL L IMITATIONS IN C ANCER S URVIVORS A MONG E LDERLY M EDICARE B ENEFICIARIES Prachi P. Chavan, MD, MPH Epidemiology PhD Student Xinhua Yu MD.
Health Behavior Profile for Adults with Mobility Limitations Gwyn C. Jones, PhD National Rehabilitation Hospital Center for Health and Disability Research.
Module 3: Alzheimer’s Disease – What is the Role of Public Health? A Public Health Approach to Alzheimer’s and Other Dementias.
Funded by NIDDK RO1 DK53942 Women’s Use of the Internet for Health Information: The Impact of Selected Demographic and Health Variables Mary L. Klem, PhD,
Clifford Johnson, Director U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention National Center for Health Statistics.
CHAPTER 7: Obesity in Women. Introduction 68% of U.S. population is overweight or obese. Resulting medical and psychosocial difficulties can be debilitating.
National Health and Nutrition Examination Survey (NHANES): Overview and Analysis Strategy Session 2 July 10, :30 AM - NOON.
Saving Time, Money, and Work: How to Do Secondary Data Analysis Vijay Singh, MD, MPH, MS, University of Michigan Arch Mainous III, PhD, Medical University.
Falls and Fall Prevention. Prevalence of Falls in Older Adults  33% of older adults fall each year  Falls are the leading cause of fatal and nonfatal.
P.E. PROFESSIONAL DEVELOPMENT TRAINING. WHAT ARE THE BIGGEST CONCERNS YOU HAVE ABOUT THE PHYSICAL WELL-BEING OF KIDS FROM THIS GENERATION?
 Community Health Status Assessment MAPP Phase 3 California Gaining Ground Coalition Small County Learning Community August 13, 2015 Tamara Maciel Bannan,
NS 210: Seminar 8 Nutritional Assessment in Disease Prevention Leslie Young MS RD LDN.
JENNIFER WATSON, MA NATIONAL INSTITUTE ON AGING, NIH MAY 19, 2016 Healthy Aging & Participation in Research What Older Adults Should Know.
J Clin Endocrinol Metab, Sep 2006, 91(9):
Yolo County Obesity Data Yolo County Childhood Nutrition and Fitness Forum September 18, 2004 Samrina Marshall, MD, MPH Assistant Health Officer, Yolo.
WOMEN’S HEALTH ISSUES : WHAT YOU REALLY NEED TO KNOW ABOUT DEPRESSION AND SUICIDE.
Requirements to run clinical trials: Research fee calculation, patient consent Kyoung Hwa Ha.
1Concepts of Physical Fitness 6e Presentation Package for Concepts of Fitness and Wellness 6e Section II: Concept 04 The Health Benefits of Physical Activity.
Chapter 1 Benefits and Risks Associated with Physical Activity
Presentation transcript:

Using Existing Databases to Answer Research Questions in Aging Stephen B. Kritchevsky, PhD March 3, 2015

Overview Existing data sets in career building Finding the data you Need The Health ABC Study Resources Can be Found at:

Just a few examples... Tian Q, et al. Cardiorespiratory fitness and brain diffusion tensor imaging in adults over 80 years of age. Brain Res Nov 7;1588: Goldenstein L, et al. Serum bicarbonate concentrations and kidney disease progression in community-living elders: the Health, Aging, and Body Composition (Health ABC) Study. Am J Kidney Dis Oct;64(4): Yende S, et al. Epidemiology and long-term clinical and biologic risk factors for pneumonia in community-dwelling older Americans: analysis of three cohorts. Chest Sep;144(3): Barbour KE, et al. Calciotropic hormones and the risk of hip and nonspine fractures in older adults: the Health ABC Study. J Bone Miner Res May;27(5): Park SW, et al. Excessive loss of skeletal muscle mass in older adults with type 2 diabetes. Diabetes Care Nov;32(11):

Role of Existing Data in Career Development (I) Establishes your intellectual interests –What is your brand? Link specialty concerns to a broader range of health issues for older adults. Provides a way to be productive while waiting for other activities to mature

Role of Existing Data in Career Development (II) Provides an opportunity to expand your professional network to gerontology Play funding “small ball” Generate preliminary data for grants Many studies have archived samples that may provide the raw material for ancillary studies.

Finding Data

“You can’t always get what you want, but if you try sometimes well you might find you get what you need.” Rolling Stones

How to Find Data NIA supported sites National Center for Health Statistics CMSGoogle National Archive of Computerized Data on Aging ( Approaching Lead Investigators of Existing Studies (both epidemiological studies and trials)

CDC: National Center for Health Statistics

Some Key Data Sets Health ABC3, year old well-functioning men and women followed since Longitudinal data on function, body composition and physiology. Biologic samples are available. Cardiovascular Health Study 5, followed since November CVD focused, but hospitalizations & deaths adjudicated. Biologic samples are available. Baltimore Longitudinal Survey on Aging Most extensive and comprehensive data relating to age-related physiologic changes. National Health & Aging Trend Study Has a Social Sciences Perspective. 8,000 Medicare beneficiaries followed annually. Medicare Current Beneficiary Survey Good for linking function & conditions to costs. Completely Interview Based. NHANESHas basic clinical chemistries, different exams may emphasize different / special measurements.

Gaining Access to Data

Main Approaches Data / Documentation is Publically Available. Data is available upon completion of a publications & data release process. Data is only available directly from a study investigator.

Tips What’s the win-win: You receive data, and you provide productivity and credit. The investigators you approach have poured their hearts and souls into the study. The people you work with are your future colleagues. Studies are supposed to have a data sharing process. Find out how it works, and follow it.

More things to remember You may have to sign a data use agreement You may need IRB approval Ask for as much data as possible It’s harder to get data from recently started studies Patience and persistence will pay-off

What to do when you get the data Read the key papers Read the documentation, carefully Get copies of the data collection forms and code books Understand the data structure Things you may need help with –Getting the data into an format that is easy to analyze –Deriving variables for analysis –Appropriate approaches for data that is a probability sample from a population.

The Health Aging and Body Composition Study hich=74 hich=74

Health ABC Objectives Primary: To examine whether change in body composition, particularly loss of muscle, represents a common pathway by which multiple conditions contribute to disability. General: To understand early transitions in the disablement process to support intervention development to delay or prevent decline in physical function.

Health ABC Design Longitudinal Cohort Study  N=3,075  year olds  Memphis, TN & Pittsburgh, PA  No difficulty in walking ¼ mile or climbing 10 steps & ADLs  50% Women, 41% African-American  In it’s 18 th year of follow-up

Participating Sites & Key People National Institute on Aging –Tamara Harris, MD, MS –Eleanor Simonsick, PhD University of California, San Francisco –Michael Nevitt, PhD –Steve Cummings, MD University of Pittsburgh –Anne Newman, MD, MPH University of Tennessee –Suzy Satterfield, MD Wake Forest University –Stephen B. Kritchevsky, PhD

Lean mass Bone density Body fat Weight-related health conditions Health history, socioeconomic status, psychosocial factors, behavioral risk factors weight history Functional limitation ADL disability Acute illness episodes Metabolic, Genetic or Inflammatory modifiers Death Healthy aging Past historyCore examinationMediatorsOutcomes Physical activity Anthropometry Endurance Strength Physical performance Phlebotomy Health, Aging and Body Composition Study CT-Fat depots, muscle DXA Body composition

Novel Exam Components

The Publications Process Writing Group Focused Proposal forwarded to the P&P committee through the Coordinating Center at UCSF Reviewed for scope and overlap Comments from the P&P Assignment of co-authors Data made available upon approval of the writing group proposal

Ancillary Studies

Ancillary Study Process An ancillary study adds new information to Health ABC The data becomes part of the Health ABC data base Ancillary Proposal process –File a proposal –Review –Materials made available upon approval

Go Forth and Quantify