Kenneth W. Tobin, Director, Measurement Science and Systems Engineering Division, Ph: (865) , Measurement Science and Systems Engineering at the Oak Ridge National Laboratory Energy and Engineering Science Directorate Kenneth W. Tobin, Ph.D. Director Corporate Research Fellow Measurement Science and Systems Engineering Division 1 st Annual ORNL Biomedical Science and Engineering Conference March 2009

2 Kenneth W. Tobin, Director, Measurement Science and Systems Engineering Division, Ph: (865) , Kenneth W. Tobin, Director, Measurement Science and Systems Engineering Division, Ph: (865) , Measurement Science and Systems Engineering (MSSE)  MSSE performs applied R&D in measurement science associated with …  We perform and support research in  Energy research (DOE, NRC, DOD, Industry, …)  National security (NNSA, DHS, DOD, DARPA, …)  Biomedical engineering (OBER, NIH, DARPA, DOD, TATRC …)  Basic Science (DOE, DARPA, …)  U.S. Competitiveness (U.S. Industry, WFO, …) Electronics CommunicationsSensors Signals / Patterns Robotics Systems

3 Kenneth W. Tobin, Director, Measurement Science and Systems Engineering Division, Ph: (865) , Kenneth W. Tobin, Director, Measurement Science and Systems Engineering Division, Ph: (865) , Measurement Science  We research and produce highly accurate and precise measurement technologies for complex, harsh, and high data-volume environments PHENIX detector subsystem: 300,000 readout channels, 40  s refresh rate, timing resolution <25ps MEMS/NEMS devices to measure small displacements (0.1pm/Hz -1/2 ), mass (10fg), and chemical concentration (ppt) Holographic microscopy: 1nm precision, metrology and motion (3D trajectory) Plasma temperature for Advanced Toroidal Facility (ATF): MK VACNF arrays for measuring neuro-electrical activity (neuronal interface): can resolve neurotransmitters at sub- attomolar concentrations

4 Kenneth W. Tobin, Director, Measurement Science and Systems Engineering Division, Ph: (865) , Kenneth W. Tobin, Director, Measurement Science and Systems Engineering Division, Ph: (865) , Systems Engineering  We have significant strengths in our ability to produce unique, complex, and robust integrated systems that meet the operating requirements of diverse environments and applications Army rad- hardened chemical and biological mass spectrometer Navy underwater acoustics measurement facility Electronics for high-energy physics at RHIC Human amplification platform for Navy High-resolution multi-modal pre-clinical scanner for industry Microscopy system semiconductor industry

5 Kenneth W. Tobin, Director, Measurement Science and Systems Engineering Division, Ph: (865) , Kenneth W. Tobin, Director, Measurement Science and Systems Engineering Division, Ph: (865) , Biomedical Engineering  Our biomedical engineering research enables measurements and analysis that impact human health in a number of important areas Image-based diagnosis and screening Preclinical anatomic and functional imaging Nano-structured substrates for tissue scaffolding Intraoperative surgical imaging Quantitative phase imaging of biological materials NIR imaging and 3D tissue modeling Transplant tissue monitoring systems

6 Kenneth W. Tobin, Director, Measurement Science and Systems Engineering Division, Ph: (865) , Kenneth W. Tobin, Director, Measurement Science and Systems Engineering Division, Ph: (865) ,  MSSE was formed in 2008 to build upon sixty years of scientific and engineering research at ORNL  Today we perform R&D in electronics, signals, patterns, communications, and informatics  Applying our skills and experience to the field of biomedical science has become an important research area for the applied science organizations at ORNL … Conclusion DOE OBER