Overview of Tuberculosis in Deer Classical Pathology and Immunology The Many Hosts of Mycobacteria II: Immunopathology Gettysburg, PA.

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Overview of Tuberculosis in Deer Classical Pathology and Immunology The Many Hosts of Mycobacteria II: Immunopathology Gettysburg, PA

Natural: oral, aerosol Routes of infection Tonsil Retropharyngeal LN Lung and LNs Hepatic LN Parotid LN 38% 45% of naturally infected deer have extracranial lesions Experimental: intratonsilar (40 CFU) 300 CFU- 83% infection rate Red deer (Cervus elaphus) CF % infection

Day 90Day 28 Day 180 Day days post-contact

Day 28 Day 60 Day 180 Day 328

Immunopathology in WTD Re-stimulate isolated PBMC with PPD or E:C

GATA3 Responses to M. bovis Infection

IL-17 Responses to M. bovis Infection