Osteogenesis imperfecta (compression fractures). OI-blue sclera.

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Presentation transcript:

Osteogenesis imperfecta (compression fractures)

OI-blue sclera

Osteopetrosis(Albers-Schonberg)-osteoclast defect, Inc. bone mass but still brittle

Osteochondromatosis Risk for malignancy? Chondrosarcoma

Osteochondromatosis

Osteochondromatosis w/ cartilage cap

TB in the spine (eponym)?Pott’s Dz

TB-granulomas, giant cells

Calcium stain-Normal Bone

Ca stain-Osteoporosis (Loss of Bone density)

Thick skull? Paget’s Hearing loss, Inc. serum Alk Phos, Inc. urine hydroxyproline Sxs? At Risk? osteosarcoma, CHF

Fibrous dysplasia of the rib Polyostotic FD + Café au Lait & Early Puberty? McCune-Albright

Fibrous Dysplasia-too much stroma

Osteoid osteoma

Osteoblastoma

Osteosarcoma-Codman’s Triangle #1 primary mal bone

Osteosarcoma-kids with Rb at risk, Chr 13 del Adults with previous radiation or Paget’s

Osteosarcoma Telangiotic type

Osteosarcoma-Telangiotic type

Osteosarcoma-appendicular bones

Chondroma Oiler’s-multi (one side Of the body) Mafucci’s-multi & hemangioma

Chondroma

Chondrosarcoma-axial bones

Chondrosarcoma-#2 primary mal bone

Chondrosarcoma

Chondrosarcoma-single mitosis is Dx

Ewing’s sarcoma-t(11,22)

(PAS+ ) Ewing’s

Liposarcoma-cell type? Flouret cell (multinucleated lipoblast)

Liposarcoma type?Well-diff/low grade

Liposarcoma type? Myxoid most common t12,16

Liposarcoma-myxoid signet ring cells

Liposarcoma-Pleomorphic w/ Giant lipoblast

Liposarcoma-Round cell

Liposarcoma-ugly looking isn’t it?

Mal Fibrous Histiocytoma-#1 soft tissue mal

Mal Fibrous Histiocytoma-giant cells

Mal Fibrous Histiocytoma

Synovial Sarcoma-biphasic epitheloid and spindle cell

Synovial Sarcoma-not synovial tissue

Synovial Sarcoma