Respiratory Effectiveness Group Study Proposal (REG) Insert name of Lead Investigator & key collaborating groups Please direct all questions and correspondence about this protocol to: [insert address and contact details of Lead Investigator / corresponding collaborator]

Background Enter relevant text o Enter relevant text –Enter relevant text Enter relevant text o Enter relevant text –Enter relevant text Enter relevant text o Enter relevant text –Enter relevant text

Aims & Objectives Enter relevant text o Enter relevant text –Enter relevant text Enter relevant text o Enter relevant text –Enter relevant text Enter relevant text o Enter relevant text –Enter relevant text

Study design Enter relevant text o Enter relevant text –Enter relevant text Enter relevant text o Enter relevant text –Enter relevant text Enter relevant text o Enter relevant text –Enter relevant text

Methodology Enter relevant text o Enter relevant text –Enter relevant text Enter relevant text o Enter relevant text –Enter relevant text Enter relevant text o Enter relevant text –Enter relevant text

Study population Enter relevant text o Enter relevant text –Enter relevant text Enter relevant text o Enter relevant text –Enter relevant text Enter relevant text o Enter relevant text –Enter relevant text

Outcomes Enter relevant text o Enter relevant text –Enter relevant text Enter relevant text o Enter relevant text –Enter relevant text Enter relevant text o Enter relevant text –Enter relevant text

Study Team Research team o Enter relevant text –Enter relevant text Steering Committee involvement (if relevant) o Enter relevant text –Enter relevant text Patient Advocate involvement (if relevant) o Enter relevant text –Enter relevant text

Study Limitations & Ethics Enter details of known limitations of the planned study o Enter relevant text –Enter relevant text Enter details of any ethical approvals required for the study o Enter status of the current status of such approvals

Timelines Study o Estimated start date o Estimated completion date (include estimates of planned milestones and/or phases, where relevant) Dissemination plans o Enter details of publication plans –Enter estimated dates of publication plans