Silver-haired Bat (Lasionycteris noctivagans) Vector of cryptic rabies virus 1990-2002: ~70% of 33 reported human rabies cases in the US Only 2 cases had.

Slides:



Advertisements
Similar presentations
Vaccines: When, where and why they were invented Cholera’s vaccine was founded in 1879, two years later the vaccine for anthrax was founded. In 1882 the.
Advertisements

8.L.1 – L IFE S CIENCE 8.L L L.1.1 Basic characteristics of viruses, bacteria, fungi, and parasites related to the spread, treatment, and.
Vaccine Technology. Newer Technology for Dosing:
IMMUNIZATION Immunization??? Reduce mortality and morbidity of mathernal and baby.
HOW VACCINE PROVIDES PROTECTION STIMULATORY MOLECULE SECRETIONS B CELL MACROPHAGE Step1 Macrophage takes in antigen by phagocytosis Step2 Macrophages display.
Practical Applications of Immunology
Medical Technology Department, Faculty of Science, Islamic University-Gaza MB M ICRO B IOLOGY Dr. Abdelraouf A. Elmanama Ph. D Microbiology 2008 Chapter.
Microbiology B.E Pruitt & Jane J. Stein AN INTRODUCTION TORTORA FUNKE CASE Chapter 18 Practical Applications of Immunology.
What is a monoclonal antibody?.  An antibody that recognizes a single epitope  It is made by fusing B cells with myeloma cells to produce a hybridoma.
Vaccines
Vaccines Against Viral Infection Austin Follett Medicinal Chemistry.
Vaccination. NATURALLY ACQUIRED IMMUNITY Active: Acquired through contact with microorganisms (infection). Provides long term protection. Passive: Antibodies.
Viruses.
Types of vaccines 1 - First generation vaccines are whole-organism vaccines - either live and weakened, or killed forms. [1] Live, attenuated vaccines,
Childhood Immunization How does immunisation work? – The body is given a vaccine which is a small dose of an inactive form of a bacterium or virus (germ)
Specific prophylaxis and treatment of infectious diseases Medical biology, microbiology, virology, immunology department By as. E.V. Pokryshko.
Principles of Immunization
Chapter 11 Practical Applications of Immunology. Vaccine History Variolation: Inoculation of smallpox into skin (18th century). Vaccination: Inoculation.
Edible Vaccines: eating our way to the eradication of disease.
VIRUSES Tobacco mosaic virus Influenza virus Adenovirus Bacteriophage.
Biomedical Technology Unit Treatment for heart disease Heart-lung machine Treatment for cancer Treatment for diabetes Bone marrow transplants.
The Expanded Program On Immunization (EPI). Immunization Immunization is the a process where by a person is made immune or resistant to an infection,
What is immunization Immunization is the process of conferring increased resistance (or decrease susceptibility) to infection.
Edible Vaccines. HOW IS IT DONE Approach 1 DNA sequences encoding antibodies (molecule which is able to recognise a disease-causing agent) are inserted.
Lesson 3 Viruses. Virus Tiny “organism” that is parasitic to cells Composed of two main parts: Protein outer shell called capsid Genetic material inside.
Dr.Muhammad Razzaq Malik بسم الله الرحمن الرحيم. MALARIA  Confirmed case of malaria  Indigenous case:  Malaria acquired by mosquito transmission in.
Viral Vaccine Types Viruses are inactivated with chemicals such as formaldehyde. Inactivated (killed) vaccines cannot cause an infection, but they.
HIV Influenza West Nile THE. What is a Virus? Virus ~ Infectious agent made up of a core of nucleic acid and a protein coat. Virus = Poison Not a living.
ERT314 BIOREACTOR SYSTEM CHAPTER 2: BIOLOGICAL SYSTEMS AND MEDIA DESIGN.
Goal 7 EOG REVIEW The learner will conduct investigations, use models, simulations, and appropriate technologies and information systems to build an understanding.
Viruses A virus is a NON-Living particle made of DNA or RNA and a protein coat. Look at table 25-1 on p. 487 in text book. VERY small. ~ 0.001micron.
VACCINES: PRINCIPLES & PRACTICE. What is a vaccine? - an antigenic preparation used to produce active immunity to a disease, in order to prevent or ameliorate.
Downloaded from Lecture40&41 Edible Vaccines.
Biologics. Biologics Wide range of medicinal products produced by biological processes. Isolated from a variety of natural sources and may be produced.
What’s Bugging You? A Cyberhunt Activity on Infectious Disease By Dawn Hall for Biomedical Technology.
Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings PowerPoint ® Lecture Slide Presentation prepared by Christine L. Case Microbiology.
Mr. C’s Joke/Riddle of the Day. The Role Canada is Playing How the World Keeps Diseases from Spreading Pt.2.
TM Prepared for your next patient. Discussion of Changes to the 2013 Immunization Schedules H. Cody Meissner, MD Floating Hospital for Children Tufts University.
Specific prophylaxis and treatment of infectious diseases Medical biology, microbiology, virology, immunology department.
BY
Viruses You are to write a narrative about a patient that has been infected with the Ebola Virus. Tell their story…. Include: How was the virus contracted?
DR.FATIMA ALKHALEDY M.B.Ch.B;F.I.C.M.S/C.M.
Vaccines and Immunisation
VIRUSES.
Principles of Immunization Ashry Gad Mohamed & Dr. Salwa Tayel Family & Community Department.
Update from the Office of Vaccines Research and Review, CBER/FDA NVAC Meeting Washington, D.C. February 4-5, 2003.
Note to presenter: The National Immunization Program can provide a videotape with animated sequences illustrating the biology of active and passive immunity.
Dr. Athal Humo transient Passive immunity is achieved by administration of preformed antibodies to induce transient protection against an infectious.
Infectious Diseases.  Bacteria- e.coli, salmonella, tuberculosis, gonorrhea  Viruses- HIV, influenza, ebola, chickenpox  Protists- giardia, malaria.
Vaccination. immunity adaptive natural active passive artificial active passive innate.
Principles of Vaccination Epidemiology and Prevention of Vaccine- Preventable Diseases Source: Centers for Disease Control and Prevention.
Chapter 27 Viruses The Nature of Viruses Viruses possess only a portion of the properties of organisms. Parasitic chemicals (segments of DNA of.
NEW TECHNOLOGIES IN VACCINES. Vaccination – is the introduction into the body of a weakened, killed or piece of a disease-causing agent to prevent disease.
Vaccines Dr. Sarah I. Bukhari 324 PHT PhD in Clinical Microbiology
Vaccines.
PRODUCED IN PARTNERSHIP BY:
Chapter 12-Vaccines Traditional vs. rDNA vaccines Subunit vaccines
Human rabies virus immune globulin
Viruses 5/26/2018.
To arouse their interest
Even 2,500 Years Ago, People Knew Immunity Worked.
History of Vaccines Variolation: inoculation of smallpox into skin (eighteenth century) Vaccination: Inoculation of cowpox virus into skin (Jenner) Inoculation.
Making Vaccines.
سرطان الثدي Breast Cancer
Edible Vaccines: eating our way to the eradication of disease
KEY CONCEPT Some viral diseases can be prevented with vaccines.
Viruses.
A brief discussion on passive and active (esp., vaccines) immunity
Immunopathology. Immunotherapy and immuno-prophylaxis.
Evidence-based management of bronchiolitis.
Presentation transcript:

Silver-haired Bat (Lasionycteris noctivagans) Vector of cryptic rabies virus : ~70% of 33 reported human rabies cases in the US Only 2 cases had a history of bat bite

Plant System For High-Yield Production of Recombinant Subunit Vaccines

 Safety  Cost-efficiency  Easy scale-up  Proper glycosylation  Suitable for developing countries  Possible direct delivery Vaccine Production in Plants

RABIES VIRUS NEUTRALIZING TITERS OF HUMAN SERA CONTROL EXPERIMENTAL

BIOMEDICALS FOR DISEASE PROPHYLAXIS AND TREATMENT EXPRESSED IN PLANTS AT THE BIOTECHNOLOGY FOUNDATION LABORATORIES DISEASESPLANT VACCINEAntibody Severe Acute Respiratory Syndrome (SARS) Anthrax Respiratory Syncytial Virus (RSV) Smallpox Diphtheria, Pertussis, Tetanus (DPT) Rabies HIV Avian Influenza Hepatitis B Colorectal and Breast Cancer Tobacco Tomato Cauliflower Tobacco Tomato Spinach Tobacco Swiss Chard Collard Swiss Chard Carrot Tobacco Spinach Collard Tobacco Spinach Barley Lettuce Cauliflower Tobacco ● (recently initiated) ● ●●●●●●

COMPARATIVE COSTS OF ANTI-RABIES ANTIBODIES COMPANY PRODUCTPRODUCT DESCRIPTION PRODUCT PRICE NAME SOURCE Bayer BayRabHumanhuman anti-Rabies 1500 iu $1,125. Donorsimmunoglobulins Aventis IMOGAM Human anti-Rabies 1500 iu $ 847. Rabies-HTDonorsimmunoglobulins wholesale (10-18% protein) price AbCam ab10014Mouse monoclonal mouse100 µg $ 250. Cellsantibodies Biotechnology MAb57Tobacco monoclonal mouse 100 µg $ 0.5 -$1. Foundation, Inc.