Neglected Tropical Diseases: Control & Research World Health Organization 22 April, 2017 Neglected Tropical Diseases: Control & Research P.Olliaro, WHO/TDR

NTDs in poor populations World Health Organization NTDs in poor populations 22 April, 2017 Previously neglected diseases Neglected tropical diseases TB HIV/AIDS Soil transmitted helminthiasis Schistosomiasis Lymphatic filariasis Onchocerciasis Leprosy Trachoma Leishmaniasis Buruli ulcer Chagas disease HAT Dengue … Anthrax Malaria Bovine tuberculosis Cysticercosis Echinococcosis Brucellosis Zoonotic trypanosomiasis Rabies Neglected zoonoses

Global distribution of NTDs World Health Organization Global distribution of NTDs 22 April, 2017 . ~ 1 billion people have >1 NTDs

Burden of disease (DALYs) for infectious & parasitic diseases "big three" = 46.1% "others" = 29.6 %

Countries affected by NTDs by income group World Health Organization Countries affected by NTDs by income group 22 April, 2017 More than 70% of countries and territories affected by neglected tropical diseases are low-income and low middle-income countries 100% of low-income countries are affected by at least 5 neglected tropical diseases

World Health Organization Health and poverty 22 April, 2017 Ill health is both a cause and a consequence of poverty: sick people are more likely to become poor and the poor are more vulnerable to disease and disability Good health is central to creating and sustaining the capabilities that poor people need to escape from poverty Good health is not just an outcome of development: it is a way of achieving development

Large scale interventions World Health Organization 22 April, 2017 Large scale interventions Lymphatic filariasis Leprosy Onchocerciasis Schistosomiasis Helminthiasis Trachoma Yaws Rapid Impact Interventions Improving access Case management and development of new tools Human African trypanosomiasis Chagas diseases Buruli ulcer Leishmaniasis Dengue Focused interventions Improving innovation 7

World Health Organization Dengue 22 April, 2017 Dengue is the most common mosquito-borne viral disease of humans that in recent years has become a major international public health concern. Globally, 2.5 billion people live in areas where dengue viruses can be transmitted. The geographical spread of both the mosquito vectors and the viruses has led to the global resurgence of epidemic dengue fever and emergence of dengue hemorrhagic fever (dengue/DHF) in the past 25 years with the development of hyperendemicity in many urban centers of the tropics.

Human African trypanosomiasis World Health Organization Human African trypanosomiasis 22 April, 2017 Spread by the bite of the tsetse fly, the disease flourishes in impoverished rural parts of Africa. Untreated, the disease is invariably fatal. Death follows prolonged agony. In 2006 some 70 000 people are estimated to be infected.

World Health Organization Leishmaniasis 22 April, 2017 12 millions are currently infected and 350 million people are at risk of infection. Around 1.5 million to 2 million new infections occur each year.

World Health Organization Buruli ulcer 22 April, 2017 BU has been reported from 30 countries, left untreated, the disease progresses to massive destruction of the skin and, in some cases, of bone, eyes, and other tissues. Limb amputations may be needed to save a patient's life.

World Health Organization Trachoma 22 April, 2017 Blinding trachoma affects more than 80 million people around the world. Children are mainly concerned by the infection, and every 4 people blind from trachoma 3 are women. Africa is the continent with the greatest number of endemic countries, but America, Middle-East and Asia are also endemic. SAFE strategy (Surgery, Antibiotics, Facial cleanliness, Environmental improvement) has proven its effectiveness in eliminating this scourge from humanity.

World Health Organization Leprosy World Health Organization 22 April, 2017 Leprosy is considered shameful and people hid their symptoms for fear of ostracism despite free and effective multidrug therapy. Today, the diagnosis and treatment of leprosy is easy. MDT treatment has been made available by WHO free of charge to all patients worldwide since 1995, and provides a simple yet highly effective cure for all types of leprosy.

Lymphatic filariasis (LF) World Health Organization Lymphatic filariasis (LF) 22 April, 2017 Over 120 million people are currently infected and around 1.3 billion people in more than 80 countries are at risk of infection. Drugs used against lymphatic filariasis are either donated – albendazole and ivermectin, or very inexpensive DEC. Albendazole and Ivermectin are donated by GlaxoSmithKline and Merck & C for mass administration to at-risk populations.

World Health Organization Schistosomiasis 22 April, 2017 Schistosoma haematobium is endemic in 53 countries in the Middle East and most of the African continent including the islands of Madagascar and Mauritius. In sub-Saharan Africa alone there are reckoned to be 112 million infections with S. haematobium. Praziquantel at the single dose of 40 mg/Kg body weight is a very safe and effective treatment against S. haematobium and the cost of treatment is less than 0.15 Euro.

World Health Organization Hookworms 22 April, 2017 Hookworms infect one billion people. It is calculated that 500 million women are infected by hookworms and at globally least 44 million are pregnant and infected at any time. Safe single dose treatment costs < 0.02 Euro a dose.

World Health Organization 22 April, 2017 Free and timely access to high-quality medicines Novartis Bayer Merck KGaA sanofi-aventis Johnson & Johnson Merck & Co Inc. GlaxoSmithKline Donator Unlimited quantity by 2012 for human African trypanosomiasis Pentamidine 200 million tablets 2008-2017 for Schistosomiasis Praziquantel Suramine 600 000 tablets 2007-2009 for fascioliasis Triclabendazole 500 000 tablets (120 mg) per year by 2012 for treatment of Chagas disease Nifurtimox Melarsoprol 50 million tablets in 2007 for Soil-transmitted helminths control programmes for children Mebendazole * Unlimited quantity for Leprosy and its complications MDT and Clofazimine Directly to countries for lymphatic filariasis and onchocerciasis Ivermectin * Eflornithine Unlimited quantity for lymphatic filariasis only (not for soil-transmitted helminthiasis) Albendazole Conditions Medicine * Donation made not directly to WHO "Industry is present. Your donations of drugs and other support opened an opportunity which public health has seized. Your engagement has given us the tools to take action on an unprecedented scale." Extract from the opening speech by DG at the first WHO global partners' meeting on NTD, 19-20 April 2007

Pharmaceutical gap Operational gap RESEARCH: Develop new tools Existing tools: Optimise Improve use/access FINANCING RESEARCH PARTNERING TO CONDUCT RESEARCH

Modified from Ridley D. et al Health Affairs 2006 Ascariasis Trichuriasis Hookworm disease Modified from Ridley D. et al Health Affairs 2006

Drug R&D investments, pipeline & burden Vs. R&D costs ?

Research needs Health Systems Basic science Product use Development "Operational" Research Innovation/ pharmaceutical Gap Basic science Product discovery Development (R&D) Product use Schools, Communities Health Systems "Tool deficient" Human African trypanosomiasis, Chagas dis. Buruli ulcer, Leishmaniasis, Dengue "Tool ready" Lymphatic filariasis, Leprosy, Onchocerciasis, Schistosomiasis, Helminthiasis, Trachoma, Yaws (VL in Indian subcontinent) "Vulnerable diseases" Lymphatic filariasis, Onchocerciasis, Schistosomiasis, (Helminthiases)

Current global R&D portfolio