Christopher J. Easley, Ph.D. Knowles Associate Professor Auburn University Chemistry and Biochemistry Auburn, AL, USA Auburn University Cluster Hire Initiative.

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Presentation transcript:

Christopher J. Easley, Ph.D. Knowles Associate Professor Auburn University Chemistry and Biochemistry Auburn, AL, USA Auburn University Cluster Hire Initiative Session #5: Nano-Bio Sciences Auburn University, Auburn, AL, USA December 1, 2014 Opportunities in Measurement Science and Chemical Biology using Nanoscale Assemblies

Cluster Hire Initiative, Nano-Bio Sciences December 1, 2014 Diabetes in the US (2004 – 2010)  29.1 million in U.S. (9.3%)  $245 billion in 2012 = 8 × NIH budget  Related to heart disease, Alzheimer’s, stroke, blindness, kidney disease, nervous system disease, … Centers for Disease Control (CDC), National Diabetes Statistics Report 2014, Atlanta, GA: U.S. Dept. of Health and Human Services. Sarah Illenberger

Cluster Hire Initiative, Nano-Bio Sciences December 1, 2014 Godwin, L. A.; Brooks, J. C.; Hoepfner, L. D.; Wanders, D.; Judd, R. L.; Easley, C. J., Analyst 2014, DOI: /C4AN01725K. Microfluidic Methods for Secretion Sampling from Primary Cells Collaboration with Judd group (AU Vet Med, AP&P) Boshell Diabetes and Metabolic Diseases Research Program

Cluster Hire Initiative, Nano-Bio Sciences December 1, 2014 Nanoliter-Scale Protein Assays BeforeAfter Time (s) 8-bit Red Intensity Negou, J.; Li, X.; Kim, J.; Hu, J.; Easley, C. J., 2014, in preparation. Detection of 300 attomoles of protein in ~10 minutes with direct fluorescence

Cluster Hire Initiative, Nano-Bio Sciences December 1, 2014 Rapid Protein Assays in Undiluted Human Serum Developed in collaboration with Shannon lab (AU Chem & Biochem) Additional collaborations with Simonian lab (AU Mat. Eng.) and Greene lab (AU Nutrition) Hu, J.; Wang, T.; Kim, J.; Shannon, C.; Easley, C. J., J. Am. Chem. Soc. 2012, 134, 7066–7072. Hu, J.; Shannon, C.; Easley, C. J.; et al., J. Am. Chem. Soc. 2014, 136, AU-IGP

Cluster Hire Initiative, Nano-Bio Sciences December 1, 2014 Nano-Bio Expertise in Chem. & Biochem. Dept. Imaging: Goldsmith (MRI), Easley (fluorescence), Shannon (Raman), Zhan (electrochemical) Enzymology: Duin, Ellis, Goodwin, Mansoorabadi Synthetic Chemistry: Merner (natural products, nanotubes), Schneller (antivirals), Goldsmith (MRI probes), Gorden (sensors) Computational: Acevedo, Patkowski, Ortiz

Cluster Hire Initiative, Nano-Bio Sciences December 1, 2014 Expertise Needed at Auburn University Specialties with room to grow Imaging Nanoparticle-mediated gene regulation & imaging Super-resolution fluoresecence microscopy Two-photon imaging and probe synthesis MRI imaging probes and computational analysis Mass Spectrometry Proteomics, metabolomics General Note on Hiring We should improve sharing of faculty interview schedules. How can this be done?

Cluster Hire Initiative, Nano-Bio Sciences December 1, 2014 Nano-Bio Overlap at AU (instrumentation & programs) AU MRI Research CenterBoshell Diabetes ProgramAURIC Cluster Hires: Health Sciences Cluster Hires: Computational Science CMB Program AMIL IAMIL I & AMIL IIAMIL II Metabolic Phenotyping Lab Flow Cytometry Lab *Mass Spectrometry CenterMass Spectrometry Center *NMR CenterNMR Center*Confocal Raman ImagingConfocal Raman Imaging *Microspectrophotometry*X-Ray Crystallography*EPR Spectroscopy *Fluorescence Microscopy * Housed within the Chemistry Building