BIRD MEDICAL DEVICES, Mumbai, India (A Hyperbaric O2 Initiative) Dedicated to promoting Affordable Hyperbaric Oxygen Therapy (HBOT) chambers. Call: 9769 484 123 (or) 9769 006 123 Tel: 91- 22 – 65 655 123 Email: indiahbot@gmail.com / info@indiahboit.com Websites: www.indiahbot.com / www.hyperbaricoxygentherapychamber.com Manufactured By: Hyperbaric SAC, Peru, S.America.

Hyperbaric Oxygen Therapy is often referred to as: HBOT Bird Medical Devices

BRIEF HISTORY OF HBOT 1662 - British physician to treat pulmonary disease and help with digestion.  1891 - Doctors in U.S. began using hyperbaric oxygen therapy to treat nervous disorders 1895 - Was found to be effective in treating carbon monoxide poisoning.  1928 - A five story having 60 rooms chamber for $1 million in Ohio by Dr. Cunningham 1934 - A U.S. Naval officer found it to be effective in treating decompression sickness.  1961 - Hyperbaric oxygen therapy was found to be effective in treating gas gangrene.  1963 - The first International Congress on Hyperbaric Medicine convened in USA 1966 - Hyperbaric oxygen therapy was found to be effective in treating stroke patients. 1970 - Hyperbaric oxygen therapy was found to be effective in treating multiple sclerosis.  1988 - The International Society of Hyperbaric Medicine was founded.  2000 -Hyperbaric medicine was approved by the American Board of Medical Specialties as a sub-speciality of emergency and preventative medicine. Bird Medical Devices

Hyperbaric Oxygen Therapy Humour “First tried on Human …. now being successfully used on animals. ” Bird Medical Devices

HYPERBARIC More Pressure Hyper = More or increased Baric = Related to Pressure More Pressure Word “Hyperbaric” is derived from Hebrew word for “More Pressure” Bird Medical Devices

“Hyperbaric” is More Pressure Than what pressure ? Related to which pressure? Bird Medical Devices

More Pressure Related to Atmospheric Pressure Atmospheric pressure is the pressure exerted at sea level. This pressure is referred to as One Atmospheric Pressure = 1 ATA ATA ( Atmospheric Absolute ) Bird Medical Devices

Henry’s Law Increase in atmospheric pressure allows more gas to be dissolved into any given liquid. Increase in more oxygen pressure allows more oxygen to be dissolved in body fluids. Bird Medical Devices

What is Hyperbaric Medicine ? The medical use of Oxygen At higher pressure than the atmospheric pressure Bird Medical Devices

What is Hyperbaric Oxygen Therapy ? (HBOT) Intermittant medical treatment with 100 % oxygen at a pressure greater than the normal atmospheric pressure Bird Medical Devices

MECHANISM OF ACTION 1. Hyper oxygenation: Breathing room air renders 21% oxygen at 1 ATA. Hyperbaric chamber provides up to 20 times 100% oxygen to all tissues within the body.

MECHANISM OF EFFECT 2. Direct Pressure to Oxygen Molecules: Normally only the red blood cells are capable of transporting oxygen. During HBOT, Oxygen molecules become more soluble obeying the scientific principles of Henry’s Universal Gas Law.   Oxygen crosses cell membranes and enter all of the body’s fluid systems, including plasma, synovial, lymphatic, interstitial (between cells) and cerebrospinal fluids. Bird Medical Devices

MECHANISM OF ACTION 3. Mechanical effect: Any free gas trapped in the body will decrease in volume as the pressure on it increases” Successfully applied to air embolism and decompression sickness Bird Medical Devices

MECHANISM OF ACTION: 4. Gas Wash out effect: The flooding of the body with any one gas tends to "wash out" all others. Treatment for CO intoxication and cyanide poisoning Bird Medical Devices

MECHANISM OF ACTION 5. Vasoconstriction: Causes vasoconstriction without creating hypoxia which decreases edema Useful in burns, crush injuries, interstitial bleeding, Acute brain and spinal cord injuries Bird Medical Devices

MECHANISM OF ACTION 6. Bacteriostasis Organisms that cannot survive in an oxygen rich environment are bacteria, fungi and viruses   White blood cells (leukocytes) become supercharged with Oxygen in the battle against bacteria responsible for causing infection and illness. Bird Medical Devices

MECHANISM OF ACTION 7. Superoxide Dismutase (SOD) Stimulation A Surge of Antioxidant Capabilities:    Hyperbaric Oxygen stimulates superoxides ( SOD production) Helps the body to rid itself of the byproducts of inflammation and damaging free radicals. Bird Medical Devices

MECHANISM OF ACTION 8. Angiogenesis The Formation of New Blood Vessels:    Stimulates the growth of new capillaries (angiogenesis) building a new collateral to serve injured and healthy tissues alike. Neovascularization is helpful for reaching tissues and organs that have restricted blood flow to ischemic areas. Bird Medical Devices

MECHANISM OF ACTION 9. Fibroplast and Collagen Production Fibroblast, Collagen reproduction and growth are aided by the added availability of increased oxygen provided during hyperbaric conditions. Plays a critical role in wound healing.   Bird Medical Devices

MECHANISM OF ACTION 10. Osteoblast and Osteoclast Production: Stimulate and increase production of cells like osteoblasts and osteoclasts Faster regeneration of bone.   Bird Medical Devices

14 Approved Indications by Undersea Hyperbaric medicine Society (UHMS) 1. Air or Gas Embolism 2. Carbon Monoxide Poisoning • Carbon Monoxide Poisoning Complicated By Cyanide Poisoning 3. Clostridial Myositis and Myonecrosis (Gas Gangrene) 4. Crush Injury, Compartment Syndrome and Other Acute Traumatic Ischemias 5. Decompression Sickness 6. Arterial Insufficiencies: Central Retinal Artery Occlusion, • Enhancement of Healing In Selected Problem Wounds 7. Severe Anemia 8. Intracranial Abscess 9. Necrotizing Soft Tissue Infections 10. Osteomyelitis (Refractory) 11. Delayed Radiation Injury (Soft Tissue and Bony Necrosis) 12. Compromised Grafts and Flaps 13. Acute Thermal Burn Injury 14. Idiopathic Sudden Sensorineural Hearing Loss Bird Medical Devices

OFF LABEL INDICATIONS NEUROSURGERY Gas Gangrene Non Healing Wounds, Ulcers, Diabetic Foot *Burns *Air and Gas Embolism *Blast Injuries *Deep Vein Thrombosis *Frostbite *Peripheral Vascular Ulcers-Arterial (Atherosclerosis), Decubitus (Bed Sores), Neuropathy Related (Diabetes), Various (DVT) *Burgers Disease NEUROLOGY Acute and chronic stroke *Vegetative Coma following closed head injury *Cerebral edema due brain tumours * Trauma and toxic encephalopathy * Multiple Scelorosis * Migraine * Cluster Headache *Cranial Nerve syndromes like Trigeminal Neuralgia, Optic Neuritis, Sudden Deafness *Brain stem syndrome *Retinal Artery occlusion

OFF LABEL INDICATIONS ORTHOPAEDICS *Crush Injuries *Compartment (Clostridial) *Myonecrosis (Clostridial) *Acute and Chronic Osteomyelitis, *Acute Necrotizing Fascitis *Bone Grafting *Tendon and ligament injuries *Amputation Stump infections etc *Fracture /Non Union *Oedema Under Cast MEDICINE Poisioning-Carbon Monoxide, Hydrogen Sulphide, Peyote & Cyanide *Near Drowning, hanging, Electrocution *Ileus * Exceptional blood loss-anaemia *Decompression Sickness *Pseudomembranous Colitis *Rheumatoid Arthritis (Acute) *Sickle Cell Crisis and Haematuria *Myocardial infarction *Post Cardiotomy Low Output Failure *Immune System Enhancement *Peptic Ulcers

OFF LABEL INDICATIONS OPTHALMOLOGY *Diabetic Retinopathy *Retinal Vein Thrombosis *Retinitis Pigmentosa *Retina Artery Occlusion *Toxic Amblyopia *Corneal Disorders *Glaucoma *Neovascularisation of Retina *Vascular Insufficiency PLASTIC SURGERY *Compromised Skin Flaps and Grafts *Speed Healing With Less Scar ENT Sudden Deafness * Acoustic Trauma *Meneire’s Desease * Chronic Lyringitis SKIN *Toxic Epidermal Necrolysis (Lyells Syndrome) * Lepromatous Leprosy * Refractory Mycose

Hyperbaric Oxygen Therapy How Hyperbaric Oxygen Therapy Is Administered ? * Oxygen as a drug * Hyperbaric chamber as a device Bird Medical Devices

Types of Hyperbaric Oxygen Therapy Chambers 1) Portable Hyperbaric Chambers 2) Monoplace Hyperbaric Chambers 3) Multiplace Hyperbaric Chambers Bird Medical Devices

Portable Hyperbaric Chamber Child receiving treatment Attributes: Made of inflatable Bags with zippers Maximum pressure upto 1.3/1.5 ATA 1 Adult & 1 Child Allows self and home treatment. Portable, can be carried if needed. Oxygen is supplied by oxygen concentrator Low costs and limited application Bird Medical Devices

Monoplace HBOT Chamber Patient receiving treatment Attributes Accommodates only a single person at a time. Pressurized to upto 3 ATA with 100% oxygen Access to patient through intercom communication. Patient entertainment systems -TV / Video is mounted on top Patient monitoring systems can be hooked Lower cost Mobile Bird Medical Devices

Monoplace HBOT chamber Chamber shown with the Door open and Trolley Patient being slided with the top of the trolley

Monoplace Hyperbaric Chamber

Multiplace HBOT Chamber Accommodates patients / healthcare personnel from 4 – 20 in numbers. Pressurised with medical breathing air upto 6 ATA Breath 100% oxygen through head tent or face mask Patient monitors and ventilators can be interfaced for the Critically ill Medicines can be passed through special openings during treatment Intercom communication, Internal Entertainment system like TV / video Needs larger space & fixed systems High cost Bird Medical Devices

MULTIPLACE HYPERBARIC CHAMBER Internal view of patients receiving treatment with medical attendants inside the chamber

MONO & MULTIPLACE CHAMBER ILLUSTRATED PICTURES Monoplace Chamber Multiplace Chamber

HBOT 1.) HBO therapy follows Physiological Principles and the Laws of physics 2.) HBO is Currently indicated for 14 diseases and supported by the literature 3.) Used for many off label indications internationally based on clinical research. 4.) Evidence includes testimonial, case reports and studies. Bird Medical Devices

HBOT TRAINING We arrange training to your Technician Nurse & Physician at our center in India. Training will be imparted by Internationally certified Hyperbaric Physician and Technician. Ask us for further details: Bird Medical Devices Cell: 9769 484 123 / 9769 006 123 Telf : 91-22-65 655 123 Email: indiahbot@gmail.com / info@indiahbot.com www.indiahbot.com www.indiahbot.blogspot.com Bombay, India

Hyperbaric Oxygen Therapy chambers In India. BIRD MEDICAL DEVICES Thanks. Dedicated to promoting Affordable Hyperbaric Oxygen Therapy chambers In India. Cell: 9769 484 123 / 9769 006 123 Telf : 91-22-65 655 123 Email: indiahbot@gmail.com / info@indiahbot.com www.indiahbot.com www.hyperbaricoxygentherapychamber.com Bombay, India