1 Chronic Disease Informatics Program Division of Geriatric Medicine and Gerontology Joseph Finkelstein, MD, PhD 1,2, and In cheol Jeong, PhD 1 Feasibility.

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1 Chronic Disease Informatics Program Division of Geriatric Medicine and Gerontology Joseph Finkelstein, MD, PhD 1,2, and In cheol Jeong, PhD 1 Feasibility of Interactive Biking Exercise System for Telemanagement in Elderly 2 Baltimore VA Medical Center

Exercise is considered to be an essential component of healthy aging Verney J et. al 2006 Introduction: Exercise for Healthy Aging exerciseseniorcitizens.com

Comprehensive disease management programs include exercise to promote quality of life and rehabilitation in elderly with chronic health conditions Introduction: Exercise for Disease Management lahey.org

Cycling exercise training has been shown to improve clinical outcomes in patients with chronic health conditions and promote rehabilitation in older adults – Improved clinical outcomes were reported to improve after cycling exercise in patients with chronic obstructive pulmonary disease patients in post-acute recovery phase after stroke patients recently weaned from mechanical ventilation Introduction: Cycling Exercise Costi S et al Matta T et al Harris JE et al Porta R et al. 2005

Cycling equipment is widely used in rehabilitation facilities where patient exercise may be supervised Low-cost cycling equipment is also available for use at home Introduction: Cycling Equipment southtees.nhs.uk

However, effective use of these simple low-cost exercise devices at patient homes is hampered by: – inability to monitor exercise progress in real time using simple graphical and numerical representation – absence of an alert system which would prevent exertion levels exceeding those approved by patient care providers – lack of remote connectivity allowing data exchange with a clinical care management team Introduction: Barriers to Exercise

Despite this growing demand for safe and effective home-based exercise systems designed for elderly, limited research has been conducted in utilizing telemedicine to promote use of cycling equipment for geriatric rehabilitation Previously, we demonstrated high acceptance and positive clinical impact of a physical telerehabilitation system in older adults Introduction: Current Limitations Finkelstein J et al. 2012

Describe design and implementation of a low- cost practical system facilitating safe cycling exercise at senior citizen homes and to assess its feasibility Extend our successful experience in implementing chronic disease telemanagement systems by supporting safe and effective home- based biking exercise in older adults Goals

Home Automated Telemanagement (HAT) system Self-care Clinical Decision Support Care Coordination Patient-Provider Communication Disease Education Individualized Treatment Plans Health Life Style Counseling Social Support HAT System Patient-Centered Care Delivery Model

iBikE HAT Information Flow

Technical Design of HAT system Data Collection Module Presentation Module Computing Module Communication Module Patient Unit HAT Database Decision Support Module HAT Web Server HAT Server Presentation Module Communication Module Clinician Unit

HAT Web Interface

HAT Applications – Computer-assisted education in patients with multiple sclerosis [2004] – Interactive asthma learning system utilizing a mobile phone platform [2008] – Using cell phones for chronic disease prevention and management [2008] – Home-Based Physical Telerehabilitation in Patients with Multiple Sclerosis [2008] – Digital divide: variation in internet and cellular phone use among women attending an urban sexually transmitted infections clinic [2010] – Feasibility of congestive heart failure telemanagement using a Wii-based telecare platform [2010] – Implementing Home Telemanagement of Congestive heart Failure Using Xbox Gaming Platform [2011] – Comprehensive disease telemanagement in veterans with multiple sclerosis [2013]

Technical Design of iBikE HAT System

iBikE Components Cycling machine ECG sensor, PPG sensor, Accelerometer Exercise monitoring software (National Instruments, USA) Chattanooga Deluxe Exerciser, Chattanooga, USA Shimmer Research, Dublin, Ireland 3 axis 12 bits accelerometer signals with the 1.5g range and the 0.024g sensitivity and the sampling rate 51.2 Hz Lead II 16 bits ECG signal with the 0.05 to 159 Hz frequency range and the sampling rate Hz Class 2 Bluetooth radio communications

iBikE HAT System

Home-Based Interactive Cycling

iBikE HAT Program

Accuracy of Cycle Count and Reliability of Alarm detection SpeedSubject Total 1 Program ±9.78 Monitor ±9.78 Accuracy100 2 Program ±18.37 Monitor ±18.37 Accuracy100 3 Program n/a ±14.73 Monitor n/a ±14.73 Accuracy100 n/a100 Subject Total Count10 10±0 Error Comparing the monitor’s blind-count and the numeric count indicator Analyzing the ability to detect cycling speed reaching a pre-setup threshold Upper Extremity

Accuracy of Cycle Count and Reliability of Alarm detection SpeedSubject Total 1 Program ±18.15 Monitor ±18.15 Accuracy100 2 Program ±12.14 Monitor ±12.14 Accuracy100 3 Program ±14.00 Monitor ±14.00 Accuracy100 Free Program ±29.74 Monitor ±29.74 Accuracy100 Subject Total Count10 10±0 Error Comparing the monitor’s blind-count and the numeric count indicator Analyzing the ability to detect cycling speed reaching a pre-setup threshold Lower Extremity

Next Step: iBikE Exercise Control Unit

Calibration of Remotely Controlled iBikE system StepResistanceN Reference SpeedCalculated SpeedDifferences MeanSDSEMeanSDSEMeanSDSE 95% CI MinMax LowerUpper All

Validation of Remotely Controlled iBikE system StepResistanceN Reference SpeedCalculated SpeedDifferences MeanSDSEMeanSDSEMeanSDSE 95% CI MinMax LowerUpper All y = 8.492x , R² =

Summary of Results – iBikE HAT allows remote setting of individualized patient exercise prescription and its continuous update by a team of clinical experts – iBikE HAT ensures safety of unsupervised exercise in elderly with multiple chronic health conditions by implementing a real-time decision support for alert generation based on exercise intensity and physiological monitoring of the patient – iBikE HAT supports bi-directional information exchange between home unit and care coordination team including exercise log, symptom diary, and patient and provider messaging – iBikE HAT is integrated into a multi-component disease management system aimed at implementing guideline- concordant care and individualized treatment plans supervised by a care coordination team – iBikE HAT allows remote exercise control

Discussion Based on our pilot testing in healthy volunteers, iBikE HAT system provided correct representation of all exercise parameters iBikE HAT program can be potentially implemented on other devices supporting physiological signal sensors and accelerometers such as iPads or iPhones

Limitations and Future Research The limitation of the current study is that it was done in a small sample of healthy volunteers In our previous work, we demonstrated that the HAT system was well accepted by patients with chronic health conditions and it improved clinical outcomes in older adults The next step of the project will be assessing the clinical impact of iBikE HAT system in a representative sample of older adults Finkelstein J et al. 1998, 2003, and 2007