1 INTRODUCTION DEPARTMENT OF NUCLEAR MEDICINE REN-JI HOSPITAL

2 Nuclear Medicine Concept Nuclear Medicine is the science which use radioisotopes to diagnose or treatment of disease.

3 Characteristics of Nuclear Medicine b Nuclear medicine imaging provides doctors with information about both structure and function. b It is a way to gather medical information that would otherwise be unavailable, require surgery, or necessitate more expensive diagnostic tests. b Nuclear medicine imaging procedures often identify abnormalities very early in the progress of a disease— long before many medical problems are apparent with other diagnostic tests.

4 Nuclear Medicine in modern Clinical Medicine and Research Today, nuclear medicine offers procedures that are essential in many medical specialties, from pediatrics to cardiology to psychiatry. New and innovative nuclear medicine treatments that target and pinpoint molecular levels within the body are revolutionizing our understanding of and approach to a range of diseases and conditions.

5 Classification of Nuclear Medicine. b Nuclear Medicine imaging. b In vivo function test b Immunoassay b Radionuclide Therapy

6 Nuclear Medicine imaging Process whereby a radionuclide is injected or measured (through tissue) from an external source, and a display is obtained from any one of several rectilinear scanner or gamma camera systems.

7 Classified by imaging time Static Dynamic Static Dynamic

8 Local Whole body Local Whole body Classified by imaging part

9 Classified by imaging method Planar Tomography

10 Classified by lesion uptake Positive imaging Negative imaging

11 Functional Study b Thyroid uptake test b Renogram

12 Immunoassay b It’s a technique to detect micro substances in body fluid. b This technique has been developed in 1959 by Solomen Berson and Rosalyn Yalow in Bronx, New York. For their contribution of this important analytical technique to medical science, R. Yolow and Berson shared the Nobel price in Medicine and physiology in 1977.

13 Radionuclide Therapy b Internal Irradiation b Contact Irradiation b Intracavitary Irradiation b Interstitial Irradiation

14 The History of Nuclear Medicine

15 French Physicist discovered radioactivity in 1896 Henri Becquerel ( )

16 German physicist who discovered X- rays in 1895 Wilhelm Röentgen ( )

17 French physicist who, along with his wife Marie Sklodowska Curie, isolated polonium and radium in 1898 Pierre Curie ( )

18 American physicist who won the 1939 Nobel Prize in physics for the invention of the cyclotron Ernest O. Lawrence ( )

19 American inventor of the scintillation scanning camera in Hal Anger

20 Nuclear Medicine is the major technique in molecular imaging