Retinoblastoma By Toni Dempsey Ben Landry Natalie Parsley Guy Staton Tiffany Wilcox Ashley Willmann

What is Retinoblastoma? Childhood cancer Childhood cancer Caused by immature retinal cells in one or both eyes Caused by immature retinal cells in one or both eyes It is most common eye cancer in children It is most common eye cancer in children 350 new cases in US each 350 new cases in US each year and over 5000 cases year and over 5000 cases worldwide worldwide

Common Signs A white “glow” in the pupil of the eye in dim lighting A white “glow” in the pupil of the eye in dim lighting Crossed or misaligned eyes Crossed or misaligned eyes Poor vision Poor vision Swollen tissue around the eye Swollen tissue around the eye

Diagnosis Fundoscopic examination Fundoscopic examination Computed tomography scan Computed tomography scan MRI MRI Blood tests Blood tests Genetic and/or DNA testing Genetic and/or DNA testing

Treatment Individualized for each patient – patients survival is primary goal Individualized for each patient – patients survival is primary goal Enucleation Enucleation External Beam Radiation External Beam Radiation Radioactive Plaques Radioactive Plaques

Treatment (cont.) Laser Therapy Laser Therapy Cryotherapy Cryotherapy Chemoreduction/Chemotherapy Chemoreduction/Chemotherapy New Clinical Trial Treatments New Clinical Trial Treatments

Case Study Child diagnosed at 2 years of age with Bilateral Retinoblastoma Child diagnosed at 2 years of age with Bilateral Retinoblastoma Treated with Chemotherapy and Radiation Treated with Chemotherapy and Radiation Both eyes eventually had to be enucleated Both eyes eventually had to be enucleated He developed unique adaptations He developed unique adaptations

Implications Early diagnosis is critical Early diagnosis is critical If left untreated cancer can spread If left untreated cancer can spread Over 95% of children in US survive and lead normal lives Over 95% of children in US survive and lead normal lives Follow up appointments are important to detect possible secondary cancers Follow up appointments are important to detect possible secondary cancers