U.S. Dept. Agriculture Agricultural Research Service Rob Griesbach Technology Transfer Coordinator

~2300 Permanent Full-Time Scientists ~100 Locations

ARS National Research Programs  Nutrition, Food Safety & Quality  Animal Production & Protection  Crop Production & Protection  Natural Resources & Sustainable Agricultural Systems

bioinformatics

Bioinformatics  DNA sequence analysis  Genome annotation  Mutation analysis  Gene expression analysis  Protein structure/interaction prediction  Comparative genomics  Biodiversity measurements  Computational evolutionary biology  Biological systems modeling

Plant & Microbial Genetic Resource Management  Conserve genetic diversity  Develop molecular tools to maximize diversity in conserved populations  Develop comprehensive germplasm database- GRIN (Germplasm Resources Information Network)

 Develop software & tools to interconnect multiple germplasm data sets  Develop easy-to-use public interfaces Plant Genome Database Stewardship & Informatics Tool Development

 Develop genetic maps, libraries, & markers  Develop analytic tools for complex genomes (polyploidy, hybrids, etc.) Structural Comparison & Analysis of Crop Genomes

 Identify genes controlling key traits  Develop new mapping strategies  Map populations for allele identification Genetic Analyses & Mapping of Important Traits in Plants

 Describe function of key genes  Identify genetic networks associated with key traits Advancing From Model Plants to Crop Plants

 Discover, detect & identify new diseases & pathogens  Develop systems to understand pathogen diversity to predict pathogenicity Detection, Identification, Characterization & Classification of Pathogens

 Identify genes for key traits  Expand genomic information on function & regulation of gene expression  Determine changes in gene expression during development Applying Genomics to Crop Improvement

Preserve & Curate Animal Genetic Resources  Conserve genetic diversity  Develop molecular tools to maximize diversity in conserved populations  Develop comprehensive germplasm database- GRIN (Germplasm Resources Information Network)

 Develop maps of chicken, bovine, porcine, catfish, rainbow trout, oysters, & salmon  Develop libraries & tools for gene expression in tissues, during development & across environments Develop Animal Genome-Enabling Tools & Reagents

 Identify genes for nutrient utilization, health, reproduction, stress resistance, & product quality  Develop molecular diagnostics for genetic evaluation & improvement systems Identify Functional Genes & Their Interactions in Animals

 Identify diversity associated with host response to bacterial infection  Identify viral genes responsible for pathogenesis  Develop new biotherapeutic platforms Genetic & Biological Determinants of Disease Susceptibility

 Develop genetic prediction tools & methods for key traits  Develop tools & methods for utilizing molecular data in evaluation & prediction programs Develop & Implement Animal Genome- Enabled Genetic Improvement Programs

 Determine in cell, animal models, & human feeding studies how nutrition & physical activity reduce the risk of disease  Determine bioavailability of nutrients & factors that modulate their levels Identify Roles of Food, Nutrients, Food Components, & Physical Activity in Promoting Health & Preventing Disease

Define the Nutritional Bases for & Consequences of Nutritional Programming  Determine how nutrition & health affect development & regulation of organ structure & function  Determine critical periods of development during which targeted nutritional & physical activity interventions are most likely to have long-term health benefits

Understand Mechanisms by which Nutrition Promotes Healthy Development & Function from Conception to Old Age  Develop tools & models to investigate changes in physiology through life  Determine the impact of nutrition & health on age-specific physiological changes

Improve the Scientific Basis for Updating National Dietary Standards & Guidelines  Determine genetic basis for inter-individual variation in nutrient requirements  Develop biomarkers for dietary exposure & health

Cooperative Research & Development Agreements 55 new 207 active Trust Fund Agreements 1,259 new 4,084 active Patents 107 applications filed 35 patents issued Licenses 25 new 339 active

BARC MD Partners 75 Researchers 134 Active agreements ($12M) with companies & institutions

Patenting 8 registered patent agents Located in MD, IL, CA Licensing 4 senior licensing specialists HQ based Tech Transfer Coordinators 7 specialists with life science / ag background Distributed across Areas Marketing Targeted marketing Web subscribe Tech Alerts Partnering opportunities Centralized in policy and approvals, licensing, marketing Decentralized in negotiation and implementation of CRADAs Office of Technology Transfer

David Nicholson - PWA Bryan Kaphammer - NPA / SPA Renee Wagner - MWA Vic Chavez- NAA Thomas Valco- Cotton Technology Don Nordlund- SAA / MSA Rob Griesbach - BA