INTRAVENOUS REOLYSIN IN BONE AND SOFT TISSUE SARCOMA METASTATIC TO LUNG M Mita, MD, MSc Clinical Investigator Assistant Professor of Medicine, IDD at CTRC/UTHSCSA.

Slides:



Advertisements
Similar presentations
I I. B.- T R E A T M E N T P L A N: DOCETAXEL 75 mg/m2 40 mg/m2 THORACIC RT (66 Gys: 180 cGy/d) CISPLATIN 40 mg/m2 Days E V A L U A.
Advertisements

Brown JR et al. Proc ASH 2013;Abstract 523.
1 Results of the Phase 3, placebo-controlled trial (SUCCEED) evaluating the mTOR inhibitor ridaforolimus as maintenance therapy in advanced sarcoma patients.
Introduction  Soft Tissue Sarcoma (STS) are a group of highly chemotherapy resistant tumors  Doxorubicin is the only APPROVED 1 st line chemotherapy.
Targeting Tumors Using Endogenous Albumin
Phase III Study Comparing Gemcitabine plus Cetuximab versus Gemcitabine in Patients with Locally Advanced or Metastatic Pancreatic Adenocarcinoma Southwest.
November 2006 Phase II Study of Dasatinib in Advanced Sarcoma SARC 009 Coordinating site: University of Michigan.
Vascular issues associated with bevacizumab Stuart M. Lichtman, MD, FACP 65+ Clinical Geriatric Program Associate Attending Memorial Sloan-Kettering Cancer.
A PHASE II TRIAL OF PERIFOSINE IN PATIENTS WITH CHEMO-INSENSITIVE SARCOMAS A SARCOMA ALLIANCE FOR RESEARCH THROUGH COLLABORATION (SARC) STUDY Study Update.
A phase I study on the combination of neoadjuvant radiotherapy plus pazopanib in patients with locally advanced soft tissue sarcoma of the extremities.
1 Phase II trial of sequential gemcitabine and carboplatin followed by paclitaxel as first-line treatment of advanced urothelial carcinoma Presented by.
Phase II Study of Dasatinib in Advanced Sarcomas SARC 009 Study PI: Scott Schuetze Registration and eCRF: CRAB Drug supply: BMS.
Efficacy and Safety of Single Agent Sunitinib in Treating Advanced Hepatocelluar Carcinoma Patients After Sorafenib Failure: A Prospective, Open-Label,
Randomized phase III trial of trabectedin versus doxorubicin-based chemotherapy as first-line therapy in translocation-related sarcomas (TRS) Sant P. Chawla,
A PHASE 2 STUDY OF TH-302 IN COMBINATION WITH DOXORUBICIN IN ADVANCED SOFT TISSUE SARCOMA Sant P Chawla, MD Sarcoma Oncology Center Santa Monica, CA Sant.
Thymidine phosphorylase (TP) upregulation Dose- and time-dependent upregulation of TP in human colon cancer xenografts PaclitaxelDocetaxel.
Cabozantinib (XL184) in Metastatic Castration-Resistant Prostate Cancer (mCRPC): Results from a Phase II Randomized Discontinuation Trial Hussain M et.
Weekly MLN9708, an Investigational Oral Proteasome Inhibitor, in Relapsed/Refractory Multiple Myeloma: Results from a Phase I Study After Full Enrollment.
Inclusion Criteria Patient has definitive histologically or cytologically confirmed metastatic adenocarcinoma of the pancreas. The definitive diagnosis.
ESP1/SARC025 Global Collaboration: A Phase I Study of a Combination of the PARP inhibitor, Niraparib and Temozolomide in Patients with Previously Treated,
A Phase II Trial of Perifosine in Patients with Chemo-Insensitive Sarcomas Study Update – November 2008 Dejka Araujo, MD MD Anderson Cancer Center, Houston,
Results of Docetaxel Plus Oxaliplatin (DOCOX) +/- Cetuximab in Patients with Metastatic Gastric and/or Gastroesophageal Junction Adenocarcinoma: Results.
Phase II Study of Dasatinib in Advanced Sarcomas SARC009 Sarcoma PI: Scott Schuetze GIST PI: Jon Trent Registration and eCRF: CRAB, Seattle Drug Supply:
CE-1 IRESSA ® Clinical Efficacy Ronald B. Natale, MD Director Cedars Sinai Comprehensive Cancer Center Ronald B. Natale, MD Director Cedars Sinai Comprehensive.
Ibrutinib in Combination with Bendamustine and Rituximab Is Active and Tolerable in Patients with Relapsed/Refractory CLL/SLL: Final Results of a Phase.
A Phase II Study with Carfilzomib, Cyclophosphamide and Dexamethasone (CCd) for Newly Diagnosed Multiple Myeloma Bringhen S et al. Proc ASH 2013;Abstract.
Ibrutinib, Single Agent or in Combination with Dexamethasone, in Patients with Relapsed or Relapsed/Refractory Multiple Myeloma (MM): Preliminary Phase.
MABEL – a large multinational study of cetuximab plus irinotecan in metastatic colorectal cancer progressing on irinotecan H Wilke, R Glynne-Jones, J Thaler,
Lenalidomide Is Safe and Active in Waldenstrom Macroglobulinemia (WM) 1 Updated Results from a Multicenter, Open-Label, Dose-Escalation Phase 1b/2 Study.
Updated Results of a Phase I First-in-Human Study of the BCL-2 Inhibitor ABT-199 (GDC-0199) in Patients with Relapsed/Refractory (R/R) Chronic Lymphocytic.
AVADO TRIAL David Miles Mount Vernon Cancer Centre, Middlesex, United Kingdom A randomized, double-blind study of bevacizumab in combination with docetaxel.
Treon SP et al. Proc ASH 2013;Abstract 251.
Activation of insulin like growth factor 1 receptor (IGF-1R) signaling pathway is implicated in proliferation, survival, and angiogenesis in pancreatic.
MEASURING CLINICAL EFFICACY IN PHASE II TRIALS Response: Karnofsky, WHO, RECIST Event rate: progression free/survival Time to event: progression/survival.
. Background Paclitaxel and Irinotecan in Platinum Refractory or Resistant Small Cell Lung Cancer: a Galician Lung Cancer.
Phase II Study of Dasatinib (BMS ) in Advanced Sarcomas and Chordoma Coordinating Center: U Michigan.
Raafat R. Abdel-Malek, MD, FRCR Ass. Prof Clinical Oncology Cairo University, Egypt Efficacy & Toxicity of Sunitinib in mRCC patients in Egypt.
A Phase 2 Study with a Daily Regimen of the Oral mTOR Inhibitor RAD001 (Everolimus) in Patients with Metastatic Clear Cell Renal Cell Cancer Amato RJ et.
12 th Annual CTOS Meeting 2006 AP23573 Induced Long-term Stability in 2 Patients with Desmoplastic Small Round Cell Tumor (#561) Scott Schuetze, Warren.
EORTC OSN/CTOS11 Safety of Caelyx combined with ifosfamide in previously untreated adult patients with advanced or metastatic soft tissue sarcomas. Final.
P.A. Tang 1, S. J. Cohen 1, G. Bjarnason 1, C. Kollmannsberger 1, K. Virik 1, M. J. MacKenzie 1, J. Brown 1, L. Wang 1, A. Chen 2, M. J. Moore 1 1 Princess.
Patterns of Care in Medical Oncology Treatment of Metastatic Colon Cancer.
1 A Randomized, Multi-Center Phase III Trial of Irinotecan in Combination with Three Different Methods of Administration of Fluoropyrimidine with Celecoxib.
1 NDA Clofarabine Cl-F-Ara-A Presented by Martin Cohen, M.D. at the December 01, 2004 meeting of the Oncologic Drugs Advisory Committee meeting.
MITO 25 A randomized phase II trial of Carboplatin-Paclitaxel- Bevacizumab vs Carboplatin-Paclitaxel-Bevacizumab- Rucaparib vs Carboplatin-Paclitaxel-Rucaparib.
Erlotinib plus Gemcitabine Compared with Gemcitabine Alone in Patients with Advanced Pancreatic Cancer: A Phase III Trial of the National Cancer Institute.
Results of a Phase 2, Multicenter, Single-Arm Study of Eribulin Mesylate as First-Line Therapy for Locally Recurrent or Metastatic HER2-Negative Breast.
MITO 25 A randomized phase II trial of Carboplatin-Paclitaxel-Bevacizumab vs Carboplatin-Paclitaxel-Bevacizumab-Rucaparib vs Carboplatin-Paclitaxel-Rucaparib.
Single-agent nab-Paclitaxel Given Weekly (3/4) as First-line Therapy for Metastatic Breast Cancer (An International Oncology Network Study, #I )
Romidepsin in Association with CHOP in Patients with Peripheral T-Cell Lymphoma: Final Results of the Phase Ib/II Ro-CHOP Study Dupuis J et al. Proc ASH.
Kantarjian HM et al. Proc ASH 2012;Abstract Long-Term Follow-Up of Ongoing Patients in 2 Studies of Omacetaxine Mepesuccinate for Chronic Myeloid.
RANDOMIZED PHASE II STUDY OF NABPACLITAXEL, IN RECURRENT ADVANCED OR METASTATIC CERVICAL CANCER MITO CER-NAB Enrica Mazzoni, MD Medical Oncology & Breast.
CCO Independent Conference Coverage
MITO 25 A randomized phase II trial of Carboplatin-Paclitaxel-Bevacizumab vs Carboplatin-Paclitaxel-Bevacizumab-Rucaparib vs Carboplatin-Paclitaxel-Rucaparib.
Randomized Phase III Study Of Gemcitabine
Alessandra Gennari, MD PhD
Farletuzumab in platinum sensitive ovarian cancer with low CA125
Gajria D et al. Proc SABCS 2010;Abstract P
NCI/CTEP 7435: Eribulin Active, Tolerable in Urothelial Cancer CCO Independent Conference Highlights of the 2015 ASCO Annual Meeting* May 29 - June 2,
Vahdat L et al. Proc SABCS 2012;Abstract P
KEYNOTE-012: Durable Efficacy With Pembrolizumab in PD-L1–Positive Gastric Cancer CCO Independent Conference Highlights of the 2015 ASCO Annual Meeting*
SAFETY AND EFFICACY OF EVEROLIMUS PLUS EXEMESTANE IN METASTATIC BREAST CANCER BEYOND THE SECOND LINE TREATMENT: A SINGLE INSTITUTION EXPERIENCE M. Giampaglia,
Intervista a Lucio Crinò
Ospedale Misericordia, Grosseto
Fowler NH et al. Proc ASCO 2010;Abstract 8036.
CTCL: INNOVATIVE TREATMENTS GEMCITABINE
Seymour JF et al. Proc ASH 2013;Abstract 872.
- Phase 1 Signalling Study
MITO 26 PHASE II TRIAL ON TRABECTEDIN IN THE TREATMENT OF ADVANCED UTERINE AND OVARIAN CARCINOSARCOMA (CS)
Presentation transcript:

INTRAVENOUS REOLYSIN IN BONE AND SOFT TISSUE SARCOMA METASTATIC TO LUNG M Mita, MD, MSc Clinical Investigator Assistant Professor of Medicine, IDD at CTRC/UTHSCSA San Antonio

BACKGROUND  Reolysin (reovirus serotype 3) –Dearing strain, naturally occurring, ubiquitous, non-enveloped human reovirus –Genome 10 segments of double-stranded RNA –Community-acquired infection is mild and limited to the upper respiratory and GI tract. –Virus replicates specifically in transformed cells possessing an activated Ras pathway.

BACKGROUND –The preferential lysis of cells with activated Ras pathway by reovirus appears to be due to the inhibition of double-stranded RNA-activated protein kinase (PKR) in these cells. –In cells with Ras non-activated pathway, PKR autophosphorylates in the presence of viral transcripts, which activates it and results in inhibition of viral protein synthesis, thus preventing viral replication. –In cells with activated RAS pathway the autophosphorylation of PKR is inhibited keeping it in an inactive state and allowing viral replication and eventually oncolysis.

Reovirus in a cell with non- activated Ras pathway

Reovirus growth in a cell with Ras activated pathway

RATIONALE  Sarcomas –Rare tumors –Very heterogeneous –Incurable when metastatic, median survival 12 m. –Available treatments are few with low RR and high toxicity –There is an acute need for new drugs for treatment of sarcoma

RATIONALE  in vitro cytotoxicity assays in Ewing’s sarcoma, rhabdomyosarcoma, synovial sarcoma, and osteosarcoma cell lines revealed complete cell kill. (Kolb et al., AACR 2006)  in vivo antitumor effect seen in xenograft models of pediatric sarcomas. (Ewing’s sarcoma and rhabdomyosarcoma).  In all tumor lines evaluated, the reovirus exhibited significant antitumor activity, including a complete response in a rhabdomyosarcoma line.  CONCLUSION : –REOLYSIN demonstrated excellent anti-tumor activity in vitro and in vivo in sarcoma cell lines.

 PHASE II multi-institutional, open-label, single agent study designed to characterize the efficacy and safety of REOLYSIN given IV every 28 days in patients with bone and soft tissue sarcoma metastatic to lung.

OBJECTIVES To measure tumor response and duration of response and describe any evidence of antitumor activity of intravenous multiple dose REOLYSIN in patients with bone and soft tissue sarcomas metastatic to the lung To evaluate safety of intravenous multiple dose of REOLYSIN

STUDY DESIGN  IV infusion over 60 minutes days 1-5  REOLYSIN DOSE 3 X TCID 50  Simon two-stage design –38 patients will be accrued to the first stage –If 1 or more responses (prolonged SD > 6 months, partial or complete response) up to 52 patients will be accrued –The agent will be considered active if 3 or more responses or prolonged SD are observed

INCLUSION CRITERIA  Pts with bone or soft tissue sarcoma metastatic to the lung unresponsive to, or untreatable by, standard therapies (histologies include osteosarcoma, Ewing sarcoma family tumors, malignant fibrous histiocytoma, synovial sarcoma, fibrosarcoma, and leiomyosarcoma).  The patients must have no sites of active disease other than lungs unless agreed by the sponsor.  Have 2 or more measurable metastatic lesions in the lungs detectable on CT scan. (RECIST)  At least 16 years of age  Have no continuing adverse effects from prior therapies; all such effects must have resolved to CTC AE version 3 ≤ grade 1

INCLUSION CRITERIA  Have received NO chemotherapy, radiotherapy, immunotherapy, hormonotherapy or surgery within 28 days prior to receiving REOLYSIN  ECOG PS ≤ 2  Life expectancy of at least 3 months  Laboratory results: –ANC ≥ 1.5 X 10 9 –Plats ≥ 100 X 10 9 –HB ≥ 9.0 g/dl –Creatinine ≤ 1.5 X ULN –Bilirubin ≤ 1.5 X ULN –AST/ALT ≤ ULN –Negative pregnancy test for females of childbearing potential

EXCLUSION CRITERIA  Concurrent therapy with any other investigational anticancer agent while on study.  Have inadequate pulmonary function defined as a forced expiratory volume in 1 second (FEV1) less than 50 % of predicted  Be on immunosuppressive therapy; have known HIV infection or active hepatitis B or C  Be a pregnant or breast feeding woman  Have clinically significant pulmonary or cardiac disease including pre-existing arrhythmia, uncontrolled angina pectoris, myocardial infarction 1 year prior to study entry, or grade 2 or higher compromised LVEF  Dementia or altered mental status  Any severe, acute or chronic medical or psychiatric condition

ENROLLMENT  35 patients  Tumor types –MFH 8 patients –Synovial sarcoma 8 patients –Osteosarcoma 6 patients –Leiomyosarcoma 6 patients –Undifferentiated round cell sarcoma 1 patient –Ewing sarcoma 1 –Liposarcoma 1 –Rhabdomyosarcoma 1 –Chordoma 1 –High grade sarcoma 1 –Alveolar sarcoma 1

PATIENT CHARACTERISTICS  Characteristics –35 patients –Age (median 51) –Sex Female -16 patients Male -19 patients –PS patients patients patients patients

PREVIOUS TREATMENTS  Previous treatment lines for metastatic disease More than 3 lines: 11 patients 1-3 lines: 20 patients None: 4 patients  Previous treatments –Chemo only: 15 patients –Chemo and XRT: 11 patients –None: 4 patients –Biological agents: 5 patients (sorafenib, mTOR inhibitors, bevacizumab)

TOXICITIES (based on 25 patients enrolled at IDD)  Constitutional grade 1 (fever, chills, fatigue, myalgias): 22 patients  Respiratory grade 1 (cough, congestion): 14 patients  Gastro-intestinal grade 1 (diarrhea): 10 patients  Hematological: occurring during the week of treatment: –Grade 2 ANC: 1 patient; Grade 3 ANC: 3 patients; grade 4 ANC-1 patient (1 day- C2D3, C3D3). –Pt KS (received 16 cycles) grade 2-3 ANC during 13 cycles of treatment (day 3-4). No neutropenia over the last 3 cycles. –Grade 2 thrombocytopenia – 2 patients –Grade 1 anemia- 3 patients.  Transaminitis: grade 2 AST/ALT – 1 patient (C1D8, C2D8, C3-5 D 5); grade 1 AST/ALT – 2 patients (C1D3 and C2D3)  Palpitations: 2 patients (both with osteosarcoma, large lung mets). 1 patient had objective findings (arrythmia) received B blockers (etiology: possibly hypoxia).

EFFICACY  1 patient (synovial sarcoma) SD after cycle 16 (ongoing).  1 patient Ewing sarcoma SD after 8 cycles (ongoing).  1 patient with osteosarcoma SD after 6 cycles (ongoing).  3 other patients SD after 4 cycles (leiomyosarcoma, chordoma, MFH).  15 patients SD after 2 cycles.  15 patients PD.  No tumor reduction.  6/29 patients had SD > 16 weeks 21%  15/29 patients had SD for at least 8 weeks (2-16 months) 52%  4 patients are too early for evaluation; 2 patients came off study before tumor evaluation.

CONCLUSION  REOLYSIN PHASE II SARCOMA –35 patients enrolled to date –Mild to moderate toxicities –2 nd cycle better tolerated than 1st –3 patients SD for at least 6 months –21% patients SD >16 weeks –52% patients SD for at least 8 weeks

CONCLUSION  The study achieved the established objectives after the first 33 patients enrolled  Enrollment will continue to 52 patients  Future studies with Reolysin in combination with chemotherapy are planned in this patient population

Acknowledgements IDD at CTRC/UTHSCSA: Tony Carmona, Alain Mita, John Sarantopoulos, Kamalesh Sankhala, Francis Giles Montefiore Medical Center: Sanjay Goel Mayo Clinic: Scott Okuno U Michigan Cancer Center: Rashmi Chugh Oncolytics: Karl Mettinger, Matt Coffey, Brad Thompson, Merle Kirkpatrick, Cathy Ward.

THANK YOU

The Institute for Drug Development A leader in anticancer drug development