Overview of the Immune System Immune System Innate (Nonspecific) Cellular Components Humoral Components Adaptive (Specific) Cell- Mediated Humoral (Ab)

Slides:



Advertisements
Similar presentations
Antigens & HLA Dr.Ghada Boghdadi.
Advertisements

Innate Immunity (part 1) BIOS 486A/586A
DEPARTMENT OF IMMUNOBIOLOGY Antigens (Ag) Xiaowu Hong Department of Immunology Shanghai Medical College of Fudan University.
Antibodies.
Antigens. Definitions Immunogen Immunogen Antigen (Ag) Antigen (Ag) Hapten Hapten Epitope or Antigenic Determinant Epitope or Antigenic Determinant Antibody.
Antigens Where we’re going- Immunogenicity vs antigenicity
Eugene P. Mayer Office: Bldg. #2, Rm. B19 Phone:
Antigen.
Pattern recognition in the immune system. Specific peptide recognition Antibody epitopes T-cell receptors recognizing peptides presented on MHC-molecules.
Immunology Overview. Innate vs Acquired Immunity Non-specific, rapid Physical, Chemical Barriers Complex Biochemical Mechanisms –Fever –Inflammation –Complement.
CHAPTER 22 Essentials of Immunology. Overview of the Immune Response Cells and Organs of the Immune System.
Principles of Immunology Antigens 2/9/06 “It is only when you give of yourself that you truly give.” K Gibran.
Antigens. Objectives What is an antigen? What type of molecules are antigens? Can any particle/foreign body that enters the cell be an antigen? Properties.
Immunogen, antigen, epitope, hapten
BIOT 307 Kuby, Ch. 3, Antigens March, General Introduction Specificity due to recognition of antigenic determinants or epitopes Epitopes = immunologically.
Game plan Lecture Lab Antibody- antigen binding Staph, Strep and
Properties and Overview of Immune Responses
Chapter 3 Antigens Substances which can be recognized by Ig of B cells (at F ab sites) and TCR’s of T cells (when accompanied by MHC) B and T cells also.
DEFINITION AND PROPERTIES OF ANTIGEN. Antigen (Ag) - any substance, which is recognized by the mature immune system of a given organism –antigenicity.
Chapter 4 Antigen.
بسم الله الرحمن الرحيم. Antigen Samira Rajaei, MD, PhD. Assistant professor Department of Immunology Tehran University of Medical Sciences.
Innate immunity Properties of innate immunity Recognition of microbes by innate immune system –structures that are recognized (“molecular patterns”) –receptors.
Antigens, Immunogens, Epitopes, and Haptens. Innate and adaptive immunity:
Innate and Adaptive Immunity
Chapter 52 Immune Sytem By: Group D: Daniel Cazares del Castillo, Fabian Abarca, Justin Cruz, Jayce Frank, William Hoover, Alberto Rodriguez.
DEFINITION AND PROPERTIES OF ANTIGEN. Antigen (Ag) - any substance, which is recognized by the mature immune system of a given organism –antigenicity.
Review: Cells of the Immune System From Larsson and Karlsson (2005)
4th SEMINAR THE ADAPTIVE IMMUNE RESPONSE: ANTIGENS AND ANTIGEN-SPECIFIC RECEPTORS.
110/30/2015 Antigens Antigens Hugh B. Fackrell 210/30/2015 ä Assigned Reading ä Content Outline ä Performance Objectives ä Key terms ä Key Concepts ä.
HUMORAL IMMUNITY Primary molecular component: antibody
Antigen IMMUNOLOGY Chen Weilin, Ph.D Institute of immunology, ZJU.
Antigen and Antigenicity Antigen and Antigenicity
1- Antigens Antigen: any substance that stimulate the specific immune response (antibody or a T-cell ) and binds specifically to them Epitope, or, Antigenic.
Antigen Presenting Cells
Immunogens, Antigens, and Haptens
Antigen.
Dr. Nabil MTIRAOUI, M.Sc, Ph.D Lecture 7 Antigens and Immunogens Properties and Characteristics.
Antigen AND Immunogen and Antibodies
Fe A. Bartolome, MD, FPASMAP Department of Microbiology Our Lady of Fatima University.
ANTIGENS  Antigen: Any substance reacting with the products of any specific immune response (Ig or T cells)  Immunogen: Any substance capable to induce.
Antigens, Immunogens, Epitopes, and Haptens: Antigen: a molecule or part of a molecule that is recognized by the immune system. The term is associated.
Antigens & Immunogen.
___________DEFENSES of the HOST: THE IMMUNE RESPONSE
DEFINITION AND PROPERTIES OF ANTIGEN
Overview of the Immune System Immune System Innate (Nonspecific) Cellular Components Humoral Components Acquired (Adaptive Specific) Cell-Mediated Humoral.
Innate Immune Response innate soluble mediators & receptors ( innate soluble mediators & receptors ) Lecture 3 8/9/2015.
Basic Concepts of Immunology Scott Barnum, Ph.D..
E. Salehi Tel: Antigens با نام و ياد خدا.
Book, Abul K. Abbas: Basic Immunology
Components of the Immune System.
Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Chapter 13 Innate and Adaptive Immunity.
GENERAL IMMUNOLOGY PHT 324 Dr. Rasheeda Hamid Abdalla Assistant Professor
Host Response to Infection
Specific Defenses of the Host Adaptive or Specific Immunity.
LEC-02 Basic Immunology 1. 2 Summery of the Total immunology unit  Kill the pathogen and don’t harm the host.
Chapter 4 Antigen. Definitions of antigen Antigen: non-self substances which can combine with TCR or BCR or Ab and have the potential of inducing immune.
GENERAL IMMUNOLOGY PHT 324
Antigens // are molecules that can be recognized by the immunoglobulin receptor of B cells or by the T-cell receptor when complexed with MHC. immunogens.
Reactions of innate immunity
Antigens Substances that can be recognized by the immunoglobulin receptor of B cells, or by the T cell receptor when complexed with MHC are called antigens.
Antigens Ali Al Khader, MD Faculty of Medicine
Immunology By Assistant Professor Dr. Ahmed Ali Mohammed.
Foreign agenses, molecules, cells
Antigen.
Immunogens and Antigens
Zhijian Cai, Ph.D Institute of immunology, ZJU
Reactions of innate immunity
مادة المناعة-النظري\ المرحلة الثالثة
Introduction/Terminology
A schematic presentation of secreted, endocytic, and signaling pattern-recognition receptors. A schematic presentation of secreted, endocytic, and signaling.
Presentation transcript:

Overview of the Immune System Immune System Innate (Nonspecific) Cellular Components Humoral Components Adaptive (Specific) Cell- Mediated Humoral (Ab)

Antigens

Definitions Immunogen Antigen (Ag) Hapten Epitope or Antigenic Determinant Antibody (Ab)

Factors Influencing Immunogenicity Contribution of the Immunogen Foreignness Size Conformational determinants Sequence determinants Chemical Composition –Primary Structure –Secondary Structure –Tertiary Structure –Quarternary Structure

Factors Influencing Immunogenicity Contribution of the Immunogen Foreigness Size Chemical Composition Physical Form –Particulate > Soluble –Denatured > Native

Factors Influencing Immunogenicity Contribution of the Immunogen Foreigness Size Chemical Composition Physical Form Degradability –Ag processing by Ag Presenting Cells (APC)

Factors Influencing Immunogenicity Contribution of the Biological System Genetics –Species –Individual Responders vs Non-responders Age

Factors Influencing Immunogenicity Method of Administration Dose Route –Subcutaneous > Intravenous > Intragastric Adjuvant –Substances that enhance an immune response to an Ag

Chemical Nature of Immunogens Proteins Polysaccharides Nucleic Acids Lipids –Some glycolipids and phosopholipids can be immunogenic for T cells and illicit a cell mediated immune response

Types of Antigens T-independent Polysaccharides Properties –Polymeric structure –Polyclonal B cell activation Yes -Type 1 (TI-1) No - Type 2 (TI-2) –Resistance to degradation Examples –Pneumococcal polysaccharide, lipopolysaccharide –Flagella

Types of Antigens T-dependent Proteins Structure Examples –Microbial proteins –Non-self or Altered-self proteins

Hapten-carrier conjugates Definition Native determinants Haptenic determinants Structure –native determinants –haptenic determinants

Antigenic Determinants Recognized by B cells and Ab Composition – Proteins, polysaccharides, nucleic acids, haptens –Sequence (linear) determinants –Conformational determinants Size –4-8 residues

Antigenic Determinants Recognized by B cells and Ab Composition Size Number –Limited (immunodominant epitopes) –Located on the external surfaces of the Ag Fe

Antigenic Determinants Recognized by T cells Composition –Proteins (some lipids) –Sequence determinants Processed MHC presentation (lipid presentation by MHC-like CD1) Size –8 -15 residues Number –Limited to those that can bind to MHC

Superantigens Conventional Antigen Monoclonal/Oligoclonal T cell response 1: :10 5 Superantigen Polyclonal T cell response 1:4 - 1:10 Definition

Superantigens Definition Examples –Staphylococcal enterotoxins –Staphylococcal toxic shock toxin –Staphylococcal exfoliating toxin –Streptococcal pyrogenic exotoxins

Determinants Recognized by the Innate Immune System Adaptive Immune System – Discrete Determinants –Reacts with a specific pathogen Innate Immune System – Broad Molecular Patterns –Reacts with a variety of pathogens

Determinants Recognized by the Innate Immune System PAMPs – Pathogen Associated Molecular Patterns PRRs – Pattern Recognition Receptors

PAMPPRR Biological Consequence of Interaction Microbial cell wall components ComplementOpsonization; Complement activation Mannose- containing carbohydrates Mannose-binding protein Opsonization; Complement activation PolyanionsScavenger receptorsPhagocytosis Lipoproteins of Gram + bacteria Yeast cell wall components TLR-2 (Toll-like receptor 2) Macrophage activation; Secretion of inflammatory cytokines

PAMPPRR Biological Consequence of Interaction Double stranded RNA TLR-3Production of interferon (antiviral) LPS (lipopolysaccharide of Gram – bacteria TLR-4Macrophage activation; Secretion of inflammatory cytokines Flagellin (bacterial flagella) TLR-5Macrophage activation; Secretion of inflammatory cytokines

PAMPPRR Biological Consequence of Interaction U-rich single stranded viral RNA TLR-7Production of interferon (antiviral) CpG containing DNA TLR-9Macrophage activation; Secretion of inflammatory cytokines

Eugene P. Mayer Office: Bldg. #2, Rm. B18 Phone: