Copyright ©2009 by Pearson Education, Inc. Upper Saddle River, New Jersey All rights reserved. The Pharmacy Technician: Foundations and Practices Mike Johnston, Karen Davis, and Jeff Gricar The Pharmacy Technician FOUNDATIONS AND PRACTICES Chapter 1 History of Pharmacy Practice

Copyright ©2009 by Pearson Education, Inc. Upper Saddle River, New Jersey All rights reserved. The Pharmacy Technician: Foundations and Practices Mike Johnston, Karen Davis, and Jeff Gricar Figure 1.2 Ancient humans and medicine. (Used with permission of Pfizer, Inc. Images by Robert Thom. All rights reserved.)

Copyright ©2009 by Pearson Education, Inc. Upper Saddle River, New Jersey All rights reserved. The Pharmacy Technician: Foundations and Practices Mike Johnston, Karen Davis, and Jeff Gricar Ancient Mesopotamia Earliest known record of apothecary practice, approximately 2,600 BCE Healers combined roles of priest, pharmacist, and physician Clay tablets recorded symptoms of illness, prescriptions, and instructions for compounding remedies

Copyright ©2009 by Pearson Education, Inc. Upper Saddle River, New Jersey All rights reserved. The Pharmacy Technician: Foundations and Practices Mike Johnston, Karen Davis, and Jeff Gricar Ancient China Legendary Emperor Shen Nung researched the medicinal value of herbs, testing many of them on himself, approximately 2,000 BCE Shen Nung wrote the first Pen T-Sao, or native herbal, recording 365 drugs In modern times, Shen Nung is still worshipped as the patron god of Chinese drug guilds

Copyright ©2009 by Pearson Education, Inc. Upper Saddle River, New Jersey All rights reserved. The Pharmacy Technician: Foundations and Practices Mike Johnston, Karen Davis, and Jeff Gricar Retrieved from

Copyright ©2009 by Pearson Education, Inc. Upper Saddle River, New Jersey All rights reserved. The Pharmacy Technician: Foundations and Practices Mike Johnston, Karen Davis, and Jeff Gricar Ancient Egypt Two classifications of workers: echelons and chiefs of fabrication Echelons were gatherers and preparers of drugs, similar to modern pharmacy technicians Chiefs of fabrication were the head pharmacists

Copyright ©2009 by Pearson Education, Inc. Upper Saddle River, New Jersey All rights reserved. The Pharmacy Technician: Foundations and Practices Mike Johnston, Karen Davis, and Jeff Gricar Papyrus Ebers Most important ancient pharmaceutical record Written in 1,500 BCE A collection of 800 prescriptions; specifically mentions 700 unique drugs

Copyright ©2009 by Pearson Education, Inc. Upper Saddle River, New Jersey All rights reserved. The Pharmacy Technician: Foundations and Practices Mike Johnston, Karen Davis, and Jeff Gricar Papyrus Ebers

Copyright ©2009 by Pearson Education, Inc. Upper Saddle River, New Jersey All rights reserved. The Pharmacy Technician: Foundations and Practices Mike Johnston, Karen Davis, and Jeff Gricar Ancient India The Charaka Samhita recorded more than 2,000 drugs Written as early as 1,000 BCE Meaning “compendium of wandering physicians,” the Charaka Samhita was the work of multiple authors

Copyright ©2009 by Pearson Education, Inc. Upper Saddle River, New Jersey All rights reserved. The Pharmacy Technician: Foundations and Practices Mike Johnston, Karen Davis, and Jeff Gricar Ancient Greece Terra Sigilata, or "sealed earth", was the first therapeutic agent to bear a trademark Originated in Greece before 500 BCE Composed of sacred clay that was blessed, refined, shaped into uniform tablets, impressed with an official seal, sun-dried, and then distributed commercially

Copyright ©2009 by Pearson Education, Inc. Upper Saddle River, New Jersey All rights reserved. The Pharmacy Technician: Foundations and Practices Mike Johnston, Karen Davis, and Jeff Gricar Terra Sigillata Retrieved from

Copyright ©2009 by Pearson Education, Inc. Upper Saddle River, New Jersey All rights reserved. The Pharmacy Technician: Foundations and Practices Mike Johnston, Karen Davis, and Jeff Gricar Theophrastus One of the greatest early Greek philosophers and natural scientists Observed and wrote extensively on the medicinal qualities of herbs Known as the father of botany His unusually accurate observations and writings date to about 300 BCE

Copyright ©2009 by Pearson Education, Inc. Upper Saddle River, New Jersey All rights reserved. The Pharmacy Technician: Foundations and Practices Mike Johnston, Karen Davis, and Jeff Gricar Use slide of Figure 1.3, “Hippocrates of Cos,” from the textbook Figure 1.3 Hippocrates of Cos. (Stock Montage/Hulton Archive/Getty Images.)

Copyright ©2009 by Pearson Education, Inc. Upper Saddle River, New Jersey All rights reserved. The Pharmacy Technician: Foundations and Practices Mike Johnston, Karen Davis, and Jeff Gricar Hippocrates Greek physician who lived between 460 BCE and 377 BCE Known as the father of medicine Commonly regarded as one of the most notable figures in medicine of all time Rejected the widely held views that illness was connected to mystic or demonic forces and positioned medicine as a branch of science

Copyright ©2009 by Pearson Education, Inc. Upper Saddle River, New Jersey All rights reserved. The Pharmacy Technician: Foundations and Practices Mike Johnston, Karen Davis, and Jeff Gricar Hippocrates (cont.) Published more than 70 writings related to the practice of medicine and apothecary Hippocratic Oath: physicians pledge to “do no harm”

Copyright ©2009 by Pearson Education, Inc. Upper Saddle River, New Jersey All rights reserved. The Pharmacy Technician: Foundations and Practices Mike Johnston, Karen Davis, and Jeff Gricar Theory of Humors Connects personal health to harmony among four bodily fluids, known as humors Each humor also related to a mood or personality characteristic –Blood (happiness) –Phlegm (lethargy) –Yellow bile (irritability) –Dark or “black” bile (melancholy)

Copyright ©2009 by Pearson Education, Inc. Upper Saddle River, New Jersey All rights reserved. The Pharmacy Technician: Foundations and Practices Mike Johnston, Karen Davis, and Jeff Gricar Ancient Rome Mithridates VI developed poisons, preventives, and treatments around 100 BCE Used himself and prisoners as subjects on which to test poisons and antidotes During the first century CE, Pedanios Dioscorides wrote De Materia Medica, which was used by medical professionals as late as the sixteenth century

Copyright ©2009 by Pearson Education, Inc. Upper Saddle River, New Jersey All rights reserved. The Pharmacy Technician: Foundations and Practices Mike Johnston, Karen Davis, and Jeff Gricar Galen Practiced and taught both pharmacy and medicine during 130–200 CE His principles of preparing and compounding medicines reigned in the Western world for 1,500 years His name still is associated with the class of pharmaceuticals compounded by mechanical means: galenicals

Copyright ©2009 by Pearson Education, Inc. Upper Saddle River, New Jersey All rights reserved. The Pharmacy Technician: Foundations and Practices Mike Johnston, Karen Davis, and Jeff Gricar Use slide of Figure 1.4, “The first apothecaries,” from the textbook Figure 1.4 The first apothecaries. (Used with permission of Pfizer, Inc. Images by Robert Thom. All rights reserved.)

Copyright ©2009 by Pearson Education, Inc. Upper Saddle River, New Jersey All rights reserved. The Pharmacy Technician: Foundations and Practices Mike Johnston, Karen Davis, and Jeff Gricar Development of the Apothecary In 8th century, Arab practitioners separated the arts of the apothecary and physician The first apothecaries, or privately owned drug stores, appeared in Baghdad Arab apothecaries developed new medicines Traveling Muslims brought the new system of pharmacy to Europe and Africa

Copyright ©2009 by Pearson Education, Inc. Upper Saddle River, New Jersey All rights reserved. The Pharmacy Technician: Foundations and Practices Mike Johnston, Karen Davis, and Jeff Gricar Use slide of Figure 1.5, “The first pharmacopoeia,” from the textbook Figure 1.5 The first pharmacopoeia. (Used with permission of Pfizer, Inc. Images by Robert Thom. All rights reserved.)

Copyright ©2009 by Pearson Education, Inc. Upper Saddle River, New Jersey All rights reserved. The Pharmacy Technician: Foundations and Practices Mike Johnston, Karen Davis, and Jeff Gricar Development of the Pharmacopeia The first pharmacopeia, the Nuovo Receptario, was published in Florence, Italy, in 1498 One of the earliest constructive collaborations between the Guild of Apothecaries and the Medical Society

Copyright ©2009 by Pearson Education, Inc. Upper Saddle River, New Jersey All rights reserved. The Pharmacy Technician: Foundations and Practices Mike Johnston, Karen Davis, and Jeff Gricar The First Anglo-Saxon Organization for Pharmacists The Guild of Grocers monopolized trade in drugs and spices In 1617, King James I formed a separate company for apothecaries

Copyright ©2009 by Pearson Education, Inc. Upper Saddle River, New Jersey All rights reserved. The Pharmacy Technician: Foundations and Practices Mike Johnston, Karen Davis, and Jeff Gricar The First Apothecary in the American Colonies Apothecaries from Europe were largely unwilling to emigrate to the American colonies John Winthrop, first Governor of Massachusetts Bay Colony and founder of Boston, sought advice from English apothecaries and physicians

Copyright ©2009 by Pearson Education, Inc. Upper Saddle River, New Jersey All rights reserved. The Pharmacy Technician: Foundations and Practices Mike Johnston, Karen Davis, and Jeff Gricar The First Apothecary in the American Colonies (cont.) In 1640, Winthrop began selling imported European medicines and medicines derived from native New England plants

Copyright ©2009 by Pearson Education, Inc. Upper Saddle River, New Jersey All rights reserved. The Pharmacy Technician: Foundations and Practices Mike Johnston, Karen Davis, and Jeff Gricar The 18th Century America’s first female pharmacist, Elizabeth Marshall America’s first hospital, Philadelphia, 1751 –Founded by Benjamin Franklin –The hospital’s pharmacy began operations in 1752

Copyright ©2009 by Pearson Education, Inc. Upper Saddle River, New Jersey All rights reserved. The Pharmacy Technician: Foundations and Practices Mike Johnston, Karen Davis, and Jeff Gricar The 18th Century (cont.) John Morgan, pharmacist and physician –Advocated written prescriptions –Advocated for the independent practice of the two professions

Copyright ©2009 by Pearson Education, Inc. Upper Saddle River, New Jersey All rights reserved. The Pharmacy Technician: Foundations and Practices Mike Johnston, Karen Davis, and Jeff Gricar The 18th Century (cont.) America’s first Apothecary General, Andrew Craigie –Duties included procurement, storage, manufacture, and distribution of the Army's drugs –Also developed an early pharmaceutical wholesaling and manufacturing business

Copyright ©2009 by Pearson Education, Inc. Upper Saddle River, New Jersey All rights reserved. The Pharmacy Technician: Foundations and Practices Mike Johnston, Karen Davis, and Jeff Gricar The 19th century America’s first college of pharmacy, the Philadelphia College of Pharmacy The American Pharmaceutical Association –Founded to meet the needs for better intercommunication among pharmacists –Set standards for education and apprenticeship –Began quality control over imported drugs

Copyright ©2009 by Pearson Education, Inc. Upper Saddle River, New Jersey All rights reserved. The Pharmacy Technician: Foundations and Practices Mike Johnston, Karen Davis, and Jeff Gricar Use slide of Figure 1.6, “The father of American pharmacy, William Procter, Jr.,” from textbook Figure 1.6 The father of American pharmacy, William Procter, Jr. (Used with permission of Pfizer, Inc. Images by Robert Thom. All rights reserved.)

Copyright ©2009 by Pearson Education, Inc. Upper Saddle River, New Jersey All rights reserved. The Pharmacy Technician: Foundations and Practices Mike Johnston, Karen Davis, and Jeff Gricar The 19th century (cont.) The father of American pharmacy, William Procter, Jr. –Graduated from the Philadelphia College of Pharmacy in 1837 –Operated a retail pharmacy –Served as professor of pharmacy for 20 years –Was a leader in founding the American Pharmaceutical Association –Editor of the American Journal of Pharmacy for 22 years

Copyright ©2009 by Pearson Education, Inc. Upper Saddle River, New Jersey All rights reserved. The Pharmacy Technician: Foundations and Practices Mike Johnston, Karen Davis, and Jeff Gricar The 19th century (cont.) The United States Pharmacopoeia –Published in 1820 –First book of drug standards to achieve national acceptance The father of modern genetics, Gregor Mendel

Copyright ©2009 by Pearson Education, Inc. Upper Saddle River, New Jersey All rights reserved. The Pharmacy Technician: Foundations and Practices Mike Johnston, Karen Davis, and Jeff Gricar USP: Then and Now Then Now

Copyright ©2009 by Pearson Education, Inc. Upper Saddle River, New Jersey All rights reserved. The Pharmacy Technician: Foundations and Practices Mike Johnston, Karen Davis, and Jeff Gricar The 20th century The American Council on Pharmaceutical Education –Founded in 1932 to establish standards for pharmacy education –Initially established standards for baccalaureate degree in pharmacy; added the doctor of pharmacy standards as an alternative

Copyright ©2009 by Pearson Education, Inc. Upper Saddle River, New Jersey All rights reserved. The Pharmacy Technician: Foundations and Practices Mike Johnston, Karen Davis, and Jeff Gricar Evolution of the Pharmacist’s Role The traditional era (1900–1930): formulating and dispensing drugs derived from natural sources The scientific era (1930–1960): development of new drugs; scientific testing; mass production of synthetic drugs and antibiotics

Copyright ©2009 by Pearson Education, Inc. Upper Saddle River, New Jersey All rights reserved. The Pharmacy Technician: Foundations and Practices Mike Johnston, Karen Davis, and Jeff Gricar Evolution of the Pharmacist’s Role (cont.) The Clinical Era (1960–1990): pharmacists expected to dispense drug information, warnings, advice, and suggestions to patients The Pharmaceutical Care Era (current era): practice of pharmacy focused on ensuring positive outcomes for drug- related therapies

Copyright ©2009 by Pearson Education, Inc. Upper Saddle River, New Jersey All rights reserved. The Pharmacy Technician: Foundations and Practices Mike Johnston, Karen Davis, and Jeff Gricar Biotechnology Drugs are produced using living organisms such as yeast, bacteria, or mammalian cells The majority are manufactured through recombinant DNA technology –A human gene capable of triggering specific protein production is inserted into a living organism and cultured in a laboratory

Copyright ©2009 by Pearson Education, Inc. Upper Saddle River, New Jersey All rights reserved. The Pharmacy Technician: Foundations and Practices Mike Johnston, Karen Davis, and Jeff Gricar Biotechnology (cont.) The majority are manufactured through recombinant DNA technology –The organism incorporates the gene into its cell structure, and begins producing the desired protein (drug) The majority of drugs being so developed are tested for use in the treatment of cancer or cancer-related conditions

Copyright ©2009 by Pearson Education, Inc. Upper Saddle River, New Jersey All rights reserved. The Pharmacy Technician: Foundations and Practices Mike Johnston, Karen Davis, and Jeff Gricar Use slide of Figure 1.7, “DNA and pharmacogenomics: The future of pharmacy,” from the textbook Figure 1.7 DNA and pharmacogenomics: The future of pharmacy.

Copyright ©2009 by Pearson Education, Inc. Upper Saddle River, New Jersey All rights reserved. The Pharmacy Technician: Foundations and Practices Mike Johnston, Karen Davis, and Jeff Gricar Pharmacogenomics Predicts whether a patient will have a severe, negative reaction to a prescribed medication Simple, rapid DNA test used May aid in selection of better medications for patient Still in development