Mother and Child Health: Research Methods G.J.Ebrahim Editor Journal of Tropical Pediatrics, Oxford University Press.

Slides:

Advertisements

Similar presentations

Why do Q.A.? Physician’s Expectations Diagnosis Therapy Technology Physician’s Expectations Diagnosis Therapy Technology.

Advertisements

Lecture 3 Validity of screening and diagnostic tests

Chapter 4 Pattern Recognition Concepts: Introduction & ROC Analysis.

Medical Statistics Joan Morris Professor of Medical Statistics Goldsmiths Lecture 2014.

Diagnostic Tests Patrick S. Romano, MD, MPH Professor of Medicine and Pediatrics Patrick S. Romano, MD, MPH Professor of Medicine and Pediatrics.

Mother and Child Health: Research Methods G.J.Ebrahim Editor Journal of Tropical Pediatrics, Oxford University Press.

1 PROBABILITY AND THEORETICAL DISTRIBUTIONS. 2 Since medicine is an inexact science, physicians seldom can predict an outcome with absolute certainty.

Mother and Child Health: Research Methods G.J.Ebrahim Editor Journal of Tropical Pediatrics, Oxford University Press.

SCREENING FOR DISEASE Nigel Paneth. THREE KEY MEASURES OF VALIDITY 1.SENSITIVITY 2.SPECIFICITY 3.PREDICTIVE VALUE.

Mother and Child Health: Research Methods

Mother and Child Health: Research Methods G.J.Ebrahim Editor Journal of Tropical Pediatrics, Oxford University Press.

Statistical Fridays J C Horrow, MD, MSSTAT

Statistics for Health Care

Mother and Child Health: Research Methods G.J.Ebrahim Editor Journal of Tropical Pediatrics, Oxford University Press.

By Dr. Ahmed Mostafa Assist. Prof. of anesthesia & I.C.U. Evidence-based medicine.

Introduction to evidence based medicine

Mother and Child Health: Research Methods G.J.Ebrahim Editor Journal of Tropical Pediatrics, Oxford University Press.

Thoughts on Biomarker Discovery and Validation Karla Ballman, Ph.D. Division of Biostatistics October 29, 2007.

Mother and Child Health: Research Methods G.J.Ebrahim Editor Journal of Tropical Pediatrics, Oxford University Press.

Mother and Child Health: Research Methods G.J.Ebrahim Editor Journal of Tropical Pediatrics, Oxford University Press.

Screening Sherine Shawky, MD, Dr.PH Assistant Professor Public Health King Abdulaziz University College of Medicine

Information Mastery: A Practical Approach to Evidence-Based Care Course Directors: Allen Shaughnessy, PharmD, MMedEd David Slawson, MD Tufts Health Care.

Mother and Child Health: Research Methods G.J.Ebrahim Editor Journal of Tropical Pediatrics, Oxford University Press.

Chapter 7 Using sample statistics to Test Hypotheses about population parameters Pages

BASIC STATISTICS: AN OXYMORON? (With a little EPI thrown in…) URVASHI VAID MD, MS AUG 2012.

Basic statistics 11/09/13.

Statistics for Health Care Biostatistics. Phases of a Full Clinical Trial Phase I – the trial takes place after the development of a therapy and is designed.

Notes Over 12.7 Using a Normal Distribution Area Under a Curve.

Mother and Child Health: Research Methods G.J.Ebrahim Editor Journal of Tropical Pediatrics, Oxford University Press.

The TRial Of Preventing HYpertension (TROPHY) TROPHY.

Screening and Diagnostic Testing Sue Lindsay, Ph.D., MSW, MPH Division of Epidemiology and Biostatistics Institute for Public Health San Diego State University.

Mother and Child Health: Research Methods G.J.Ebrahim Editor Journal of Tropical Pediatrics, Oxford University Press.

Mother and Child Health: Research Methods G.J.Ebrahim Editor Journal of Tropical Pediatrics, Oxford University Press.

Appraising A Diagnostic Test

Some Common Probability Distributions Gaussian: Sum of numbers. Uniform: e.g. Dice throw. Rayleigh: Square root of the sum of the squares of two gaussians.

· Lecture 31 & 32 : Scope of clinical biochemistry ط Uses of clinical biochemistry tests ط Diagnosis, Prognosis, Screening, Monitoring ط Reporting results.

Mother and Child Health: Research Methods G.J.Ebrahim Editor Journal of Tropical Pediatrics, Oxford University Press.

Cost-effectiveness of Screening Tests Mark Hlatky, MD Stanford University.

Day 2 Seminar Types of research articles. Original research article new knowledge for the first time.

Diagnostic Tests Afshin Ostovar Bushehr University of Medical Sciences Bushehr, /7/20151.

Diagnostic Tests Studies 87/3/2 “How to read a paper” workshop Kamran Yazdani, MD MPH.

Diagnostic Test Characteristics Professor Mobeen Iqbal Shifa College of Medicine.

EVALUATING u After retrieving the literature, you have to evaluate or critically appraise the evidence for its validity and applicability to your patient.

Laboratory Medicine: Basic QC Concepts M. Desmond Burke, MD.

Managing Uncertainty Dr Katherine Teare GP Educator Fellow.

Clinical Trials 2015 Practical Session 2. Exercise I Normally Distributed Response Data H 0 :  = 0 H a :  =  a > 0 n=? α=0.05 (two-sided) β=0.20 

Sensitivity, Specificity, and Receiver- Operator Characteristic Curves 10/10/2013.

Screening for Disease: Part One

Screening System for Hypertension and Diabetes at Primary Care Level

Diagnosing Diabetes and Predicting Complications

Materials & Methods what to include and where

ABSITE statistics: the absolute basics

Clinical Study Results Publication

Bayard Roberts ECOHOST – The Centre for Health and Social Change

FAMILY MEDICINE AND LABORATORY TESTS Elham

Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults Risks and Assessment NHLBI Obesity Education.

“Sick Fat,” Metabolic Disease, and Atherosclerosis

evidence based medicine IN THE 21ST CENTURY

How do we delay disease progress once it has started?

“Sick Fat,” Metabolic Disease, and Atherosclerosis

Screening, Sensitivity, Specificity, and ROC curves

Millie D. Long, Bruce E. Sands

What are Psychological Disorders?

Diagnostic application of oxidation-reduction potential assay for measurement of oxidative stress: clinical utility in male factor infertility Ashok.

An analysis of IN.PACT DEEP randomized trial on the limitations of the societal guidelines-recommended hemodynamic parameters to diagnose critical limb.

Clinical Research Association TURKEY

Elevated High-Density Lipoprotein Cholesterol Is Associated with Hyponatremia in Hypertensive Patients Ariel Israel, MD, PhD, Ehud Grossman, MD The.

Medical Approach Physicians began using medical models to review the physical causes of these disorders. Etiology: Cause and development of the disorder.

Do meta-analyses in nephrology change the way we treat patients?

PRISMA flow diagram for selection of RCTs from leading sports medicine journals for the publication years 2005 and 2015. PRISMA, Preferred Reporting Items.

Presentation transcript:

Mother and Child Health: Research Methods G.J.Ebrahim Editor Journal of Tropical Pediatrics, Oxford University Press.

Normality and Abnormality - I In parameters with a Gausian distribution –+ 2 Standard Deviations or –+ 3 Standard Deviation may be arbitrarily considered abnormal

Normality and Abnormality - II Labeling as abnormal those findings which are regularly associated with disease e.g. blood pressure > 140 / 90 mm. Hg.

Normality and Abnormality - III Calling a measurement abnormal if treatment is proven beneficial e.g. high blood cholesterol level

Diagnostic Tests Sensitivity Specificity Positive and Negative Predictive Values of tests

Diagnostic Tests - II Do test results in patients differ from those in normal individuals? Are patients with certain levels of results more likely to have the target disease? Do test results distinguish patients with and without the disease among those clinically thought to have it? Do patients undergoing the diagnostic test do better than similar untested patients?

The Receiver Operating Characteristic (ROC) Curve

Meta - Analysis The process of making an objective and systematic analysis of information from all the randomised controlled trials

Clinical Expertise Factors Influencing Practice of Evidence – Based Medicine Patient’s Clinical State Patient’s Preferences Research Evidence Clinical expertise

Screening Tests Screening tests are different from diagnostic tests in being performed essentially on normal persons Prevalence of the disorder being screened for is important since in low prevalence settings even excellent tests perform poorly.