Substance P (SP) & Endorphin. Content Neuropeptides & pain perception – Substance P – endorphins NK1-receptor & Central opiate receptors Endorphins Enkephanlin.

Slides:

Advertisements

Similar presentations

Somatosensory perception: Touch, pain and analgesia

Advertisements

Ch 45: Hormones and Endocrine System

Chapter 47 Endocrine Regulation.

Signal transduction pathways involved in the regulation of food intake or why does Homer Simpson loves to eat an excess of donuts.

1. What does endo- mean? 2. What is a hormone? 3. What does the word negative mean? 4. What does the word diffusion mean? 5. What is mitosis? 6. What is.

Heroin Anna Markarova Julia Bataille Georgia Klein.

Synaptic Transmission Chapter 4 Pages Chemical Synapses  Most synapses in the brain are chemical. Electronically coupled gap junction synapses.

1 Stress and Disease Chapter 10. Mosby items and derived items © 2006 by Mosby, Inc. 2 Stress  A person experiences stress when a demand exceeds a person’s.

OPIOIDS NIRALI PATEL (2009) Medical University of Sofia, Faculty of Medicine Department of Pharmacology and Toxicology.

Transcutaneous Electrical Nerve Stimulation (TENS)

 What are converging neural pathways and their involvement in light sensitivity?  What are diverging neural pathways and their involvement in fine motor.

Endorphins Rachel LeBeau. Endorphins? Chemicals in the brain known as neurotransmitters 3 major types Regulate production and reception of serotonin &

9.4 Homeostasis and the Autonomic Nervous System All autonomic nerves are motor nerves that regulate organs without conscious control Motor nerves lead.

Biological Psychology

Endocrine System Coordinates and directs the activity of the body’s cells through the release of hormones into the bloodstream.

Chapter 45 Hormones & the Endocrine System. Main Ideas 1.) A hormone is a chemical signal that is secreted into the circulatory system & communicates.

Endocrine System. I. Endocrine system A. Endocrine tissues & organs are found throughout the body some along organs part of other systems others found.

Brain Analgesia System Dr Ghulam Mustafa Learning objectives What is brain analgesia system Enlist components of analgesia system Enlist chemical mediators.

Chapter 9: Opioid Analgesics

How do different analgesics prevent pain?. What is pain? pain |pān|noun physical suffering or discomfort caused by illness or injury : she's in great.

BY NKEM UMEOKOLI MSc Neuropharmacology University of East London

Principles of Pharmacology

Homeostatic Systems and Drugs Chapter 4

Endocrine System Chapter 45. What you need to know! Two ways hormones affect target organs. The secretion, target, action, and regulation of at least.

Opium Poppy. Opium Poppy: Papaver somniferum Member of the Papaveraceae, poppy family Large showy annual with conspicuous flowers (white, pink, red, purple)

Endocrine System SBI4U. Endocrine System Regulation of Body Temperature Regulation of Body’s H 2 O Content Regulation of Serum Glucose Levels Regulation.

A NEUROPEPTIDE THAT DRAMATICALLY ENHANCES LEARNING AND MEMORY POTENTIAL FOR COGNITIVE DRUG DEVELOPMENT John M. Stewart Department of Biochemistry University.

Hormones and Response Pathways Kayla Owens Michael Drew Turner.

Option H: H.1 – Hormonal Control. Hormones Chemical messenger secreted directly into the bloodstream –Secreted by endocrine cells or neurosecretory cells.

Hormones chemical substances produced in small quantities in one part of an organism and then transported to another part of an organism where they bring.

Chapter 29 Review.

1 Chemical Signals in Animals or The Endocrine System.

Institute of Laboratory Animal Science University of Zürich Molecular Genetic Analysis of Pain and Stress in the Laboratory Mouse.

BELL WORK. BODY SYSTEMS ENDOCRINE SYSTEM OBJECTIVES  identify the main function of the endocrine system.  explain the jobs done by different hormones.

Homeostasis and the Autonomic Nervous System All autonomic nerves are motor nerves that regulate organs without conscious control.

Electrochemical Impulse 9.2. Nerve Impulses (Image on previous slide: there.

Nervous and Endocrine Systems. Nervous System Functions Thought processes Coordination of movement Relays information from the body to the brain or other.

Lecture 1 CHEMICAL SIGNALLING IN THE NERVOUS SYSTEM

Chemical Signals in Animals Goiter Two Primary Systems of Internal Communication and Regulation. Nervous System Quick responses to sudden environmental.

The Glands and Hormones of the Endocrine System Endocrine System Regulation of Body Temperature Regulation of Body’s H 2 O Content Regulation of Serum.

Pain Modulaton Stopping the Hurt Pain Modulaton Stopping the Hurt.

Properties and structure:  Are carboxylic acids with α - amino group.  Are the basic building blocks of proteins.  Nearly all have an asymmetric.

Chemical Signals in Animals

By: ELIJAH RUFF. ENDORPHINES Endorphins are among the brain chemicals known as neurotransmitters, which function to transmit electrical signals within.

Hormones influence a cell’s activities by entering the cell or binding to its membrane.

Neurotransmissions in the Central Nervous System Prof. Alhaider.

Biology Chapter 26 Hormones and the Endocrine System by Emily Bower.

K 6.5 Nerves, Hormones & Homeostasis. Central Nervous System (CNS) – brain & spinal cord Coordinate incoming/outgoing information Peripheral Nervous system.

The Nervous System-Part II

Lesson Overview Lesson Overview The Endocrine System Lesson Overview 34.1 The Endocrine System.

1 Stress and Disease Chapter 10. Mosby items and derived items © 2006 by Mosby, Inc. 2 Stress  A person experiences stress when a demand exceeds a person’s.

Chapter 26 Chemical Regulation.

How the number of learning trials affects placebo and nocebo responses

CHAPTER 2 ENDOCRINE SYSTEM.

Hormones and the Endocrine system

W5D3H3: Sensory Receptors

October 24th – AP Psychology

Opiates Option D, Section 3.

Neurobiology presentation, Halász Olivér

SIGNALLING MOLECULES Hormones

Neurotransmitters.

GLEE-ful for sickle cell pain?

ION CHANNELS AS DRUG TARGETS &

General Animal Biology

David M. S. Grunkemeier, Joseph E. Cassara, Christine B

The Nervous System.

General Animal Biology

Importance of the Endocrine System

بسم الله الرحمن الرحيم.

Presentation transcript:

Substance P (SP) & Endorphin

Content Neuropeptides & pain perception – Substance P – endorphins NK1-receptor & Central opiate receptors Endorphins Enkephanlin

Substance P (SP) a kind of neuropeptide (belongs to the tachykinin neuropeptide family) Mainly found in the brain and spinal cord Substance P is an important element in pain perception

tachykinin family tachykinin family ： Phe-X-Gly-Leu-Met-NH2X X is either an Aromatic( 苯環類 ) or an Aliphatic amino acid( 酯胺酸 ) Substance P

NK1-receptor The endogenous receptor for Substance P is neurokinin 1 receptor (NK1-receptor, NK1R). NK1-receptor belongs to the tachykinin receptor sub-family of GPCRs(G-protein couple receptor) NK1-receptor is considered an attractive drug target, particularly with regards to potential analgesics and anti-depressants Tachykinin peptides Substance p Mammalian tachykinin receptor NK-1 (most attractive) NK-2 NK-3 ……….

Function of Substance P SP has been associated with the regulation of mood disorders, anxiety, stress, etc. SP also relates to Neurogenic inflammation Substance P receptor(NK1-receptor) antagonists may have important therapeutic applications in the treatment of a variety of stress-related illnesses, in addition to their potential as analgesics

Other application Cell growth ： Substance P has been known to stimulate cell growth in culture, and it was shown that Substance P could promote wound healing of non-healing ulcers in humans Diabetes ： Substance P has also been shown to reverse diabetes in mice but effects to insulin secretion seems to be species dependent. Vasodilation ： It has been shown that vasodilatation to substance P is dependent on the NK1 receptor located on the endothelium.

Why may a runner who twists his leg during a competition finish the run before he really feels the pain?

Central opiate receptors The endogenous analgesia system is a pain control system descending from brainstem to the spinal cord.

Endogenous opioids are substances with opiate-like effects. occurring in the nervous system – ß -endorphin,met-enkephalin, leu-enkephalin, dynorphin and many others Endogenous opioids are derivatives of three large protein molecules encoded by three different genes. – e.g. ACTHPOMCß -endorphin

Nerve impulseSpinal cordEndorphins ( － ):releasing pain signals Stimulation or increased tone of the analgesia system can suppress strong pain signals entering the spinal cord through the dorsal spinal horn. 背部腹部

Endorphin endogenous opioid neuropeptides function as neurotransmitters produced by the pituitary gland and the hypothalamus during exercise,excitement, pain, consumption of spicy food, love and orgasm, resemble the opiates in their abilities to produce analgesia and a feeling of well-being “endo- ” morphineendogenous “–orphin”

Enkephalin An enkephalin is a pentapeptide involved in regulating nociception in the body. Met-enkephalin

The enkephalins are termed endogenous ligands, or specifically endorphins they are internally derived and bind to the body's opioid receptors. – Met-enkephalin is Tyr-Gly-Gly-Phe-Met. – Leu-enkephalin has Tyr-Gly-Gly-Phe-Leu.

資料來源： estion?qid= estion?qid= Campbell biology campbell reece 8th edition by Reece, Campbell 2007