Presented by Dr. Soe Sandi Tint Effects of Oral Hypoglycemic Agents, Insulin And Life Style modifications On Glycemic control of Type 2 Diabetes Patients in Thailand Presented by Dr. Soe Sandi Tint

Background and Rationale Diabetes Mellitus (DM) is a clinical syndrome characterized by hyperglycemia due to absolute or relative deficiency of Insulin Type 2 Diabetes Mellitus is a Global Pandemic diseases Chronic illness that requires continuing medical care, ongoing patient self-management education and support, life style modifications and regular monitoring of their blood glucose level within normal limit to prevent severe complications

Background and Rationale Globally, about 346 million people are suffering Diabetes Many glycemic uncontrolled Diabetes patients got complications after 5 years of being diagnosed as Diabetes In Thailand 2006, only 26.3% of participants in Thai Diabetes Registry Project got control of HbA1c < 7%

Background and Rationale Metformin (OHA) is the preferred initial pharmacological agent for type 2 Diabetes Life style modification is also one of the way to achieve the target glycemic control level of HbA1c Treatment with OHA, Insulin (pharmacological treatment) and Life style modifications (non-pharmacological treatment) is know to reduce glycemia in patients with type 2 Diabetes In thailand, it is still unknown that which treatment attains target HbA1c level below 7%

Research Questions What are the baseline characteristics (Gender, Age, BMI, Duration of Diabetes, Occupation, Health care financing) among type 2 Diabetes patients in Thailand? What are the prevalence of complications among type 2 Diabetes patients in Thailand? What are the prevalence of Glycemic control and uncontrolled level among type 2 Diabetes patients in Thailand? What is the effective treatment between pharmacological (OHA, Insulin, both OHA and Insulin) and non-pharmacological among type 2 Diabetes patients in Thailand? What is the association between Glycemic level (control and uncontrolled) and baseline characteristics among type 2 Diabetes patients in Thailand?

Research Hypothesis There is association between Glycemic level (control and uncontrolled) and baseline characteristics among type 2 Diabetes patients in Thailand Life style modifications (non-pharmacological treatment) and OHA (pharmacological treatment) are the best effective treatment to attain the target HbA1c level (< 7%)

Objectives To describe the baseline characteristics (Gender, Age, BMI, Duration of Diabetes, Occupation, Health care financing) among type 2 Diabetes patients in Thailand To describe the prevalence of complications among type 2 Diabetes patients in Thailand? To describe the prevalence of Glycemic control and uncontrolled level among type 2 Diabetes patients in Thailand? To assess the effects of pharmacological and non-pharmacological treatment on glycemic control among type 2 Diabetes patients in Thailand?

Significant of the study In Thailand, there is not much information and studies about the effects of OHA, Insulin (pharmacological treatment) and Life style modifications (non-pharmacological treatment) on Glycemic control of Type 2 Diabetes patients

Research Methodology Study Design Cross sectional analytical study Study Area Ministry of Public Health and Bangkok metropolitan Administration Hospitals in Thailand Study Population Type 2 Diabetes patients aged between ---------------

Research Methodology Inclusion Criteria Type 2 Diabetes alone patients who are on the treatment of OHA, Insulin, both OHA and Insulin (Pharmacological treatment) and life style modifications (Non-pharmacological treatment) Sample Size Sample = 8421 patients Study Period -------------------

Research Methodology Sampling Technique Samples were selected based on the probability proportional to sixe of the patients for each hospital

Research Methodology Data Analysis Process Descriptive Statistics - Independent variables were described by using frequency and percentage for categorical data and mean, standard deviation were used for continuous data - HbA1c < 7% as control group and >= 7% as uncrontrol group were analyzed as dependent variables

Research Methodology Data Analysis Process Analytical statistics - Bivariate analysis was done to measure the association between dependent variable and independent variables - Logistic regression was used in this analysis - Multivariate analysis – variable having p value 0.25 or less was included in the Multivariate model

Research Methodology Limitation of the study Resource and time constrain Insufficient data and missing values in the data (secondary data)

RESULTS

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Analytical Statistics

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Thank You !