0 100 200 Condensed TUNEL + cells (%) WT RanBP9 Tg B The scale bar represents 50  m A CA1 TUNEL Wild TypeRanBP9 Tg P<0.0005 * Supplemental Fig. S1.

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Condensed TUNEL + cells (%) WT RanBP9 Tg B The scale bar represents 50  m A CA1 TUNEL Wild TypeRanBP9 Tg P< * Supplemental Fig. S1

Supplemental Fig. S2 A B C D

Supplemental Fig. S3

Supplemental Fig. S4

Thy1.2 pEYFP-N1 GFP- RanBP9 VC RanBP9 O.D at 490/690 nm VC RanBP9 pEYFP-N1 GFP RanBP9 B C UL: 2.42 UR: LL: LR: UL: 0.68 UR: LL: LR: RanBP %45.14% A VC PI Annexin V Supplemental Fig. S Stacking gel 6E10 O F 4 tetramer trimer dimer monomer fibril D

HT22 Cells Cont. RanBP9 siRNA * RanBP9 * β-actin Supplemental Fig. S6 AB * Cofilin * β-actin Cont. Cofilin siRNA C Control DAPT 5μM APP-FL APP-CTFs