Disorders associated with a positive test for Rheumatoid Factor Autoimmune Disorders RA, Primary Sjogrens, MCTD, PM/DM, Scleroderma, ANCA-Associated vasculitis, PAN, Primary Biliary Cirrhosis. Chronic Infections Subacture bacterial endocarditis, TB, Leprosy, Syphilis, Hep C, Hep B, Other viral infections, Parasitic Infections Miscellaneous Conditions Sarcoidosis, Idiopathic Pulm Fibrosis, Silicosis, Asbestosis, Malignancy, Age >65. (from: CURRENT Rheumatology, Chapter 3: Laboratory Diagnosis. McGraw-Hill Companies ). Available at Himmelfarb’s Library Website.

Conditions Associated with positive ANA detected by Indirect Immunofluorescence Rheumatic Disease SLE, MCTD, Scleroderma, Sjogren, RA, PM/DM, Discoid Lupus. Organ-Specific Autoimmune Disease Autoimmune thryoid disease, autoimmune hepatitis, Primary biliary cirrhosis, Autoimmune cholangitis. Other Drug-induces lupus, asymptomatic drug-induced ANA, chronic infections, idiopathic pulmonary fibrosis, primary pulmonary hypertension, lymphoproliferative disorders. (from: CURRENT Rheumatology, Chapter 3: Laboratory Diagnosis. McGraw-Hill Companies ). Available at Himmelfarb’s Library Website.

Selected Antinuclear Antibodies with High Sensitivity or Specificity Conditions High Sensitivity High Specificity SLE ANA Anti-dsDNA, Anti-Sm Drug-Induced Lupus ANA, antihistone -- Neonatal Cutaneous Lupus Maternal anti-Ro/SS-A -- Congenital complete heart block Maternal anti-Ro/SS-A -- MCTD ANA, anti-RNP -- Primary Sjogren Anti-Ro/SS-A (75%) -- Scleroderma (limited and Difuse) ANA (>85%) Anticentromere, anti-Scl-70 High sensitivity: >95% except where noted. High specificity: >95% except where noted. (from: CURRENT Rheumatology, Chapter 3: Laboratory Diagnosis. McGraw-Hill Companies ). Available at Himmelfarb’s Library Website.