2002 ISHLT J Heart Lung Transplant 2002; 21: HEART-LUNG TRANSPLANTATION Overall

2002 ISHLT J Heart Lung Transplant 2002; 21: NUMBER OF HEART-LUNG TRANSPLANTS REPORTED BY YEAR * Numbers may be low due to delayed reporting

2002 ISHLT J Heart Lung Transplant 2002; 21: HEART-LUNG TRANSPLANTATION ACTUARIAL SURVIVAL ( ) N=2,928 Half-life = 2.8 years Conditional Half-life = 8.2 years Survival (%)

2002 ISHLT J Heart Lung Transplant 2002; 21: HEART-LUNG RECIPIENTS Functional Status (April 1994 – December 2001)

2002 ISHLT J Heart Lung Transplant 2002; 21: HEART-LUNG RECIPIENTS Employment Status (U.S.: April 1994 – December 2001)

2002 ISHLT J Heart Lung Transplant 2002; 21: HEART-LUNG RECIPIENTS: Rehospitalization Post-transplant (April December 2001)

2002 ISHLT J Heart Lung Transplant 2002; 21: HEART-LUNG TRANSPLANTATION Adult Recipients

2002 ISHLT J Heart Lung Transplant 2002; 21: DIAGNOSIS IN ADULT HEART-LUNG TRANSPLANTS ( ) Other includes cancer, LAM, OB, bronchiectasis, retransplant, sarcoidosis

2002 ISHLT J Heart Lung Transplant 2002; 21: DIAGNOSIS IN ADULT HEART-LUNG TRANSPLANTS ( ) DiagnosisN% Congenital Heart Disease PPH CF Acquired Heart Disease904.7 COPD/Emphysema874.6 IPF593.1 Alpha Re-TX: Non-OB311.6 Sarcoidosis271.4 Re-TX: OB221.2 Bronchiectasis130.7 OB (not Re-TX)90.5 Other522.7

2002 ISHLT J Heart Lung Transplant 2002; 21: DIAGNOSIS IN ADULT HEART-LUNG TRANSPLANTS BY ERA Other includes OB (non-ReTX), Bronchiectasis, Sarcoidosis

2002 ISHLT J Heart Lung Transplant 2002; 21: ADULT HEART-LUNG RECIPIENTS Induction Immunosuppression For follow-ups between October 1999 and December 2001

2002 ISHLT J Heart Lung Transplant 2002; 21: ADULT HEART-LUNG RECIPIENTS Maintenance Immunosuppression at Any Time During Follow-up For follow-ups between October 1999 and December 2001

2002 ISHLT J Heart Lung Transplant 2002; 21: ADULT HEART-LUNG RECIPIENTS Maintenance Immunosuppression at Time of Follow-up For follow-ups between October 1999 and December 2001

2002 ISHLT J Heart Lung Transplant 2002; 21: ADULT HEART-LUNG RECIPIENTS Maintenance Immunosuppression at Time of Follow-up For follow-ups between October 1999 and December 2001

2002 ISHLT J Heart Lung Transplant 2002; 21: ADULT POST-HEART-LUNG TRANSPLANT MORBIDITY Cumulative Incidence of Survivors (April 1994-December 2001)

2002 ISHLT J Heart Lung Transplant 2002; 21: Freedom from CAV For Adult Heart-Lung Recipients (April 1994-December 2000)

2002 ISHLT J Heart Lung Transplant 2002; 21: Freedom from Bronchiolitis Obliterans For Adult Heart-Lung Recipients (April 1994-December 2000)

2002 ISHLT J Heart Lung Transplant 2002; 21: Freedom from Renal Dysfunction For Adult Heart-Lung Recipients (April 1994-December 2000) * Renal dysfunction = Creatinine > 2.5 mg/dl, dialysis or renal transplant

2002 ISHLT J Heart Lung Transplant 2002; 21: MALIGNANCY POST-HEART-LUNG TRANSPLANT FOR ADULTS Cumulative Incidence for Survivors (April 1994-December 2001) Malignancy/Type1-Year Survivors5-Year Survivors No Malignancy211 (90.9%) %) Malignancy (all types combined)21 (9.1%)6 (9.2%) Malignancy Type Skin1 Lymph142 Other22 Type Not Reported42

2002 ISHLT J Heart Lung Transplant 2002; 21: Freedom from Malignancy For Adult Heart-Lung Recipients (April 1994-December 2000)

2002 ISHLT J Heart Lung Transplant 2002; 21: ADULT HEART-LUNG TRANSPLANT RECIPIENTS: Cause of Death ( )

2002 ISHLT J Heart Lung Transplant 2002; 21: HEART-LUNG TRANSPLANTATION Pediatric Recipients

2002 ISHLT J Heart Lung Transplant 2002; 21: AGE DISTRIBUTION OF PEDIATRIC HEART-LUNG RECIPIENTS ( )

2002 ISHLT J Heart Lung Transplant 2002; 21: AGE DISTRIBUTION FOR DONORS OF PEDIATRIC HEART-LUNG RECIPIENTS ( )

2002 ISHLT J Heart Lung Transplant 2002; 21: AGE DISTRIBUTION OF PEDIATRIC HEART-LUNG RECIPIENTS By Year of Transplant Number of Transplants * Numbers may be low due to delayed reporting.

2002 ISHLT J Heart Lung Transplant 2002; 21: NUMBER OF CENTERS REPORTING PEDIATRIC HEART-LUNG TRANSPLANTS * Numbers may be low due to delayed reporting.

2002 ISHLT J Heart Lung Transplant 2002; 21: DIAGNOSIS IN PEDIATRIC HEART –LUNG TRANSPLANT RECIPIENTS (Age: Years) Other includes Alpha-1, Bronchiectasis, IPF and OB (non-ReTX)

2002 ISHLT J Heart Lung Transplant 2002; 21: PEDIATRIC HEART-LUNG TRANSPLANTATION Actuarial Survival ( ) Comparison between 1-10 years and years not significant

2002 ISHLT J Heart Lung Transplant 2002; 21: PEDIATRIC HEART-LUNG TRANSPLANTATION Actuarial Survival by Era ( ) Survival (%) No comparisons are statistically significant

2002 ISHLT J Heart Lung Transplant 2002; 21: PEDIATRIC HEART-LUNG TRANSPLANT RECIPIENTS: Cause of Death ( )