LUNG TRANSPLANTATION Pediatric Recipients 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

RECIPIENT AGE DISTRIBUTION FOR PEDIATRIC LUNG RECIPIENTS - NUMBER (Transplants: January June 2010) Analysis includes living donor transplants ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

RECIPIENT AGE DISTRIBUTION FOR PEDIATRIC LUNG RECIPIENTS - PERCENTAGE (Transplants: January June 2010) Analysis includes living donor transplants ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

DONOR TYPE DISTRIBUTION BY YEAR OF TRANSPLANT FOR PEDIATRIC LUNG RECIPIENTS (Transplants: ) NOTE: This figure includes only the lung transplants that are reported to the ISHLT Transplant Registry. As such, the presented data may not mirror the changes in the number of lung transplants performed worldwide. Analysis includes living donor transplants ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

DONOR TYPE DISTRIBUTION BY RECIPIENT AGE GROUP WITHIN ERA FOR PEDIATRIC LUNG RECIPIENTS (Transplants: January June 2010) Analysis includes living donor transplants ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

AGE DISTRIBUTION FOR DONORS OF PEDIATRIC LUNG RECIPIENTS (Transplants: January June 2010) ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

AGE DISTRIBUTION OF PEDIATRIC LUNG RECIPIENTS: By Year of Transplant Analysis includes living donor transplants NOTE: This figure includes only the pediatric lung transplants that are reported to the ISHLT Transplant Registry. Therefore, these numbers should not be interpreted as the rate of change in pediatric lung procedures performed worldwide. ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

NUMBER OF CENTERS REPORTING PEDIATRIC LUNG TRANSPLANTS Analysis includes living donor transplants ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

NUMBER OF CENTERS REPORTING PEDIATRIC LUNG TRANSPLANTS BY CENTER VOLUME Analysis includes living donor transplants ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

NUMBER OF PEDIATRIC LUNG TRANSPLANTS BY CENTER VOLUME Analysis includes living donor transplants ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

PEDIATRIC LUNG TRANSPLANTATION: Indications (Transplants: January 1990 – June 2010) DIAGNOSIS AGE: < 1 Year AGE: 1-5 Years AGE: 6-11 Years AGE: Years Cystic Fibrosis 11.2%54.5% % % Idiopathic Pulmonary Arterial Hypertension %2522.5%3010.1%756.9% Re-Transplant: Obliterative Bronchiolitis 76.3%93.0%343.1% Congenital Heart Disease %87.2%41.3%90.8% Idiopathic Pulmonary Fibrosis 910.5%2018.0%134.4%383.5% Obliterative Bronchiolitis (Not Re-TX) 109.0%196.4%454.2% Re-Transplant: Not OB 33.5%43.6%82.7%272.5% Interstitial Pneumonitis 11.2%21.8%20.7% Pulmonary Vascular Disease 89.3%76.3%31.0% Eisenmengers Syndrome 11.2%54.5%51.7%70.6% Pulmonary Fibrosis, Other 55.8%54.5%124.0%222.0% Surfactant Protein B Deficiency %32.7%10.4%10.1% COPD/Emphysema 44.7%21.8%31.0%90.8% Bronchopulmonary Dysplasia 22.3%21.8%62.0%10.1% Bronchiectasis 11.2% 51.7%131.2% Other %65.4%124.0%262.4% Analysis includes living donor transplants ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

DIAGNOSIS IN PEDIATRIC LUNG RECIPIENTS BY YEAR OF TRANSPLANT Age: Years Analysis includes living donor transplants ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

PEDIATRIC LUNG TRANSPLANTS: AGE DISTRIBUTION BY LOCATION Transplants between January 2000 and June 2010 Analysis includes living donor transplants ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

PEDIATRIC LUNG TRANSPLANTS: DIAGNOSIS DISTRIBUTION BY LOCATION Transplants between January 2000 and June 2010 NOTE: Unknown diagnoses were excluded from this tabulation. Total number of transplants reported: Europe = 359 North America = 576 Other = 54 Analysis includes living donor transplants ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

PEDIATRIC LUNG TRANSPLANTS: DONOR AGE DISTRIBUTION BY LOCATION Transplants between January 2000 and June 2010 NOTE: Transplants with unknown donor age and living donor transplants were excluded from this tabulation. Total number of transplants reported: Europe = 359 North America = 576 Other = 54 ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

LUNG TRANSPLANTATION Kaplan-Meier Survival by Recipient Age Group (Transplants: January June 2009) ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

PEDIATRIC LUNG TRANSPLANTATION Kaplan-Meier Survival by Procedure Type (Transplants: January June 2009) ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

PEDIATRIC LUNG TRANSPLANTATION Kaplan-Meier Survival for Congenital Diagnoses (Transplants: January 1990 – June 2009) ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

PEDIATRIC LUNG TRANSPLANTATION Kaplan-Meier Survival by Recipient Age Group (Transplants: January June 2009) ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

PEDIATRIC LUNG TRANSPLANTATION Conditional Kaplan-Meier Survival by Recipient Age Group (Transplants: January June 2009) ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

PEDIATRIC LUNG TRANSPLANTATION Kaplan-Meier Survival by Era (Transplants: January June 2009) ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

PEDIATRIC LUNG TRANSPLANTATION Kaplan-Meier Survival by Donor Type for Recipients Age Years (Transplants: January June 2009) ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

PEDIATRIC LUNG RE-TRANSPLANTS Between January 1994 and June 2010 Analysis includes living donor transplants ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

PEDIATRIC LUNG RETRANSPLANTS Survival for Transplants Performed Between January 1994 and June 2009 ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

PEDIATRIC LUNG RETRANSPLANTS STRATIFIED BY INTER-TRANSPLANT INTERVAL Survival for Transplants Performed Between January 1988 and June 2009 ISHLT 2011 Analysis includes living donor transplants. Only patients who were less than 18 years old at the time of re-transplant are included. ISHLT J Heart Lung Transplant Oct; 30 (10):

PEDIATRIC LUNG RETRANSPLANTS STRATIFIED BY DIAGNOSIS Survival for Transplants Performed Between January 1988 and June 2009 ISHLT 2011 Analysis includes living donor transplants. Only patients who were less than 18 years old at the time of re-transplant are included. ISHLT J Heart Lung Transplant Oct; 30 (10):

PEDIATRIC LUNG RECIPIENTS Cross-Sectional Analysis Functional Status of Surviving Recipients (Follow-ups: April 1994-June 2010) ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

PEDIATRIC LUNG RECIPIENTS Functional Status of Surviving Recipients US Recipients Only (Follow-ups: March June 2010) ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

PEDIATRIC LUNG RECIPIENTS Rehospitalization Post-transplant of Surviving Recipients (Follow-ups: April June 2010) ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

PEDIATRIC LUNG RECIPIENTS Rehospitalization Post-transplant of Surviving Recipients (Follow-ups: April June 2010) ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

PEDIATRIC LUNG RECIPIENTS Induction Immunosuppression For transplants between January 2001 and June 2010 Analysis is limited to patients who were alive at the time of the discharge ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

PEDIATRIC LUNG RECIPIENTS Induction Immunosuppression (Transplants: January June 2010) Analysis is limited to patients who were alive at the time of the discharge ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

PEDIATRIC LUNG TRANSPLANTATION Kaplan-Meier Survival Stratified by Induction Use (Transplants: January June 2009) ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

PEDIATRIC LUNG RECIPIENTS Maintenance Immunosuppression at Time of Follow-up (F ollow-ups: January 2001 – June 2010) NOTE: Different patients are analyzed in Year 1 and Year 5 Analysis is limited to patients who were alive at the time of the follow-up ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

PEDIATRIC LUNG RECIPIENTS Maintenance Immunosuppression at Time of Follow-up (Follow-ups: January 2001 – June 2010) 1 Year Follow-up (N = 348) 5 Year Follow-up (N = 153) NOTE: Different patients are analyzed in Year 1 and Year 5 NOTE: 5% of patients were on both calcineurin inhibitors at different point during the 1-year; these patients are not counted in either group. And 0.3% (1 patient) was on neither drug during the 1-year. In the 5-year tabulations, 13% were reported to be on both drugs during the year and 1% (2 patients) was reported to be on neither drugs. Analysis is limited to patients who were alive at the time of the follow-up ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

PEDIATRIC LUNG RECIPIENTS Maintenance Immunosuppression Drug Combinations at Time of Follow-up Report (Follow-ups: January 2001 – June 2010) NOTE: Different patients are analyzed in Year 1 and Year 5 Analysis is limited to patients who were alive at the time of the follow-up ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

POST-LUNG TRANSPLANT MORBIDITY FOR PEDIATRICS Cumulative Prevalence in Survivors within 1 Year Post-Transplant (Follow-ups: April June 2010) ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

POST-LUNG TRANSPLANT MORBIDITY FOR PEDIATRICS Cumulative Prevalence in Survivors within 5 Years Post-Transplant (Follow-ups: April June 2010) ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

POST-LUNG TRANSPLANT MORBIDITY FOR PEDIATRICS Cumulative Prevalence in Survivors within 7 Years Post-Transplant (Follow-ups: April June 2010) ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

Freedom from Bronchiolitis Obliterans Syndrome For Pediatric Lung Recipients (Follow-ups: April June 2010) ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

Freedom from Bronchiolitis Obliterans Syndrome Stratified by Age Group For Pediatric Lung Recipients (Follow-ups: April June 2010) ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

Freedom from Bronchiolitis Obliterans Syndrome Stratified by Diagnosis For Pediatric Lung Recipients (Follow-ups: April June 2010) ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

Freedom from Bronchiolitis Obliterans Syndrome For Pediatric Lung Recipients by Induction Use (Follow-ups: April June 2010) ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

Freedom from Severe Renal Dysfunction* For Pediatric Lung Recipients (Follow-ups: April June 2010) ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

MALIGNANCY POST-LUNG TRANSPLANTATION FOR PEDIATRICS Cumulative Incidence for Survivors (Follow-ups: April June 2010) Malignancy/Type1-Year Survivors 5-Year Survivors 7-Year Survivors No Malignancy596 (94.5%)152 (88.4%)77 (89.5%) Malignancy (all types combined)35 (5.5%)20 (11.6%)9 (10.5%) Malignancy Type* Lymph32209 Other210 Type Not Reported100 Other includes Liver and primitive neuroectodermal tumor. * Recipients may have experienced more than one type of malignancy so sum of individual malignancy types may be greater than total number with malignancy. ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

Freedom from Malignancy For Pediatric Lung Recipients (Follow-ups: April June 2010) ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

PEDIATRIC LUNG TRANSPLANT RECIPIENTS: Cause Of Death (Deaths: January June 2010) CAUSE OF DEATH 0-30 Days (N =97) 31 Days - 1 Year (N = 135) >1 Year - 3 Years (N = 176) >3 Years - 5 Years (N = 83) >5 Years (N = 82) BRONCHIOLITIS 13 (9.6%)70 (39.8%)34 (41.0%)34 (41.5%) ACUTE REJECTION 3 (3.1%)3 (2.2%)1 (0.6%)2 (2.4%)3 (3.7%) LYMPHOMA 7 (5.2%)5 (2.8%)4 (4.8%)5 (6.1%) MALIGNANCY, NON- LYMPHOMA 1 (0.7%)1 (0.6%)2 (2.4%)3 (3.7%) CMV 5 (3.7%) INFECTION, NON-CMV 13 (13.4%)46 (34.1%)26 (14.8%)17 (20.5%)11 (13.4%) GRAFT FAILURE 30 (30.9%)27 (20.0%)45 (25.6%)11 (13.3%)14 (17.1%) CARDIOVASCULAR 15 (15.5%)6 (4.4%)4 (2.3%)1 (1.2%) TECHNICAL 11 (11.3%)3 (2.2%)1 (0.6%)1 (1.2%) MULTIPLE ORGAN FAILURE 8 (8.2%)13 (9.6%)9 (5.1%)3 (3.6%)7 (8.5%) OTHER 17 (17.5%)11 (8.1%)14 (8.0%)8 (9.6%)6 (7.3%) ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

PEDIATRIC LUNG TRANSPLANT RECIPIENTS: Relative Incidence of Leading Causes of Death (Deaths: January June 2010) ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

N=795 PEDIATRIC LUNG TRANSPLANT RECIPIENTS (1/1992-6/2009) Risk Factors For 1 Year Mortality/Graft Failure ISHLT 2011 VARIABLENRelative Risk P-value95% Confidence Interval Single lung transplant On ventilator < Year of transplant: vs / < Donor CMV+/Recipient CMV ISHLT J Heart Lung Transplant Oct; 30 (10):

N=795 PEDIATRIC LUNG TRANSPLANT RECIPIENTS (1/1992-6/2009) Risk Factors For 1 Year Mortality/Graft Failure ISHLT 2011 Continuous Factors (see figures) Pediatric transplant center volume Recipient age (borderline) ISHLT J Heart Lung Transplant Oct; 30 (10):

PEDIATRIC LUNG TRANSPLANT RECIPIENTS (1/1992-6/2009) Risk Factors For 1 Year Mortality/Graft Failure Center Volume Pediatric Transplants ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

PEDIATRIC LUNG TRANSPLANT RECIPIENTS (1/1992-6/2009) Risk Factors For 1 Year Mortality/Graft Failure Recipient Age ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

N=583 PEDIATRIC LUNG TRANSPLANT RECIPIENTS (1/1992-6/2005) Risk Factors For 5 Year Mortality/Graft Failure ISHLT 2011 VARIABLENRelative Risk P-value95% Confidence Interval Single lung transplant On ventilator882.27< Year of transplant: vs / < ISHLT J Heart Lung Transplant Oct; 30 (10):

N=583 PEDIATRIC LUNG TRANSPLANT RECIPIENTS (1/1992-6/2005) Risk Factors For 5 Year Mortality/Graft Failure ISHLT 2011 Continuous Factors (see figures) Recipient age Height difference (borderline) ISHLT J Heart Lung Transplant Oct; 30 (10):

PEDIATRIC LUNG TRANSPLANT RECIPIENTS (1/1992-6/2005) Risk Factors For 5 Year Mortality/Graft Failure Recipient Age ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

PEDIATRIC LUNG TRANSPLANT RECIPIENTS (1/1992-6/2005) Risk Factors For 5 Year Mortality/Graft Failure Height Difference ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):

N=380 PEDIATRIC LUNG TRANSPLANT RECIPIENTS (1/1990-6/2000) Risk Factors For 10 Year Mortality/Graft Failure ISHLT 2011 VARIABLENRelative RiskP-value95% Confidence Interval On ventilator662.12< Single lung transplant ISHLT J Heart Lung Transplant Oct; 30 (10):

N=380 PEDIATRIC LUNG TRANSPLANT RECIPIENTS (1/1990-6/2000) Risk Factors For 10 Year Mortality/Graft Failure ISHLT 2011 Continuous Factors (see figures) Recipient age ISHLT J Heart Lung Transplant Oct; 30 (10):

PEDIATRIC LUNG TRANSPLANT RECIPIENTS (1/1990-6/2000) Risk Factors For 10 Year Mortality/Graft Failure Recipient Age ISHLT 2011 ISHLT J Heart Lung Transplant Oct; 30 (10):