Hematopoiesis & Hemostasis

Slides:

Advertisements

Similar presentations

BLOOD CLOTTING, FORMATION, & DISORDERS February 19-20, 2015.

Advertisements

© 2012 Pearson Education, Inc. Blood The only fluid tissue in the human body Classified as a Components of blood.

BLOOD “Sometimes the questions are complicated and the answers are simple.” ― Dr. Seuss.

Hematopoeisis and Hemostasis

Chapter 17 - Blood $100 $200 $300 $400 $500 $100$100$100 $200 $300 $400 $500 IntroductionErythrocytesLeukocytesHemostasis Blood Types FINAL ROUND.

Hemo, hemato refers to blood

Hematopoiesis and Hemostasis HAP Susan Chabot

HEMOSTASIS – Stoppage of Blood Flow.

Chapter 14.2: White Blood Cells and Platelets. White Blood Cells (WBCs) -Also called leukocytes -Contain a nucleus and other organelles -No hemoglobin.

Chapter 10 Blood Ms. Harborth Anatomy and Physiology II.

Essentials of Human Anatomy & Physiology Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slides 10.1 – Seventh Edition Elaine.

ELAINE N. MARIEB EIGHTH EDITION 10 Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings PowerPoint ® Lecture Slide Presentation by.

Combat infections Regulate body temperature Transport nutrients, oxygen and metabolic wastes.

Hemostasis. Hemostasis Definition Prevention of blood loss (stoppage of blood flow)

PowerPoint ® Lecture Slide Presentation by Patty Bostwick-Taylor, Florence-Darlington Technical College Copyright © 2009 Pearson Education, Inc., publishing.

Hematopoiesis Blood cell formation that occurs in the red bone marrow found in flat bones (skull, pelvis, ribs, sternum, proximal epiphyses of the humerus.

Stopping Blood Loss and Choosing the Right Transfusion Donor.

Blood. I. Function A. Transport nutrients oxygen/carbon dioxide waste B. Maintaining Homeostasis hormones C. Protection immune system II. Composition.

More than just transport… Blood. Functions of Blood 1.Deliver O 2, nutrients to all body cells 2.Transport waste products from cells for elimination 3.Transport.

BLOOD. Physical Characteristics  Color depends on oxygen content  8% of body weight  L in females, L in males  pH – slightly alkaline.

Blood. + The only fluid tissue in the human body Classified as a connective tissue Living cells = formed elements Non-living matrix = plasma.

Blood – Part 3. Hemostasis  Hemostasis – Stoppage of blood flow.  If a blood vessel wall breaks a series of reactions is set in motion.  This response.

Hematopoiesis Blood cell formation Occurs in red bone marrow Adult red marrow is found in ribs, vertebrae, sternum, pelvis, proximal humeri, and proximal.

ELAINE N. MARIEB EIGHTH EDITION 10 Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings PowerPoint ® Lecture Slide Presentation by.

Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Hematopoiesis  Blood cell formation  Occurs in red bone marrow  About one.

Arrange the slides in the proper order then change the background to a color other than white to check yourself. Close without saving to return to orginal.

Functions of Blood 1.Deliver O 2, nutrients to all body cells 2.Transport waste products from cells for elimination 3.Transport hormones 4.Maintain body.

Essentials of Human Anatomy & Physiology Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Seventh Edition Elaine N. Marieb Chapter.

BLOOD Functions of Blood Transportation – oxygen and carbon dioxide – nutrients, hormones, metabolic wastes – heat Regulation – pH through buffer systems.

BLOOD CHAPTER 10 Pg 290 Composition: liquid tissue -8% body weight -5-6 L in adult 1) Solid: 45% of blood -living cells: formed elements 1. Erythrocytes~45%

The Blood “Transport System”. Composition of the Blood Blood makes up ~8% of total body weight ~55% plasma ~45% formed elements 4 to 5 liters for average.

Blood Chapter 12. Introduction What is the function of blood? Blood transports substances (nutrients, oxygen, wastes, and hormones) Also maintains homeostasis.

PowerPoint ® Lecture Slide Presentation by Patty Bostwick-Taylor, Florence-Darlington Technical College Copyright © 2009 Pearson Education, Inc., publishing.

Cardiovascular = Circulatory System Blood. Blood General functions Amount of blood – 5-6 liters in males, 4-5 liters in females – 8% of body weight.

Essentials of Human Anatomy & Physiology Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Seventh Edition Elaine N. Marieb Chapter.

PowerPoint ® Lecture Slide Presentation by Patty Bostwick-Taylor, Florence-Darlington Technical College Copyright © 2009 Pearson Education, Inc., publishing.

Chapter 10 Blood. Physical Characteristics Fluid –Living 45% Cells –RBC Erythrocytes (carry oxygen) –WBC Leukocytes (immune) –Platelets (clotting) –Non.

ANATOMY Unit 3 Notes: Blood Pressure & Heart Disorders.

Blood Physiology. Hematopoiesis Blood cell formation Occurs in red marrow – Flat bones – Skull – Pelvis – Ribs – Sternum Lymphocytes that form T cells.

1. Hematocrit The volume of a blood sample Formed Elements Accounts for 45% of whole blood Erythrocytes Leukocytes Platelets 2.

Blood Biology 2122 Chapter 17. Characteristics/Functions 1.Connective Tissue (Formed Elements) 2.pH: Males: 5-6 L; Females: 4-5 L 4.O 2 and.

PowerPoint ® Lecture Slide Presentation by Patty Bostwick-Taylor, Florence-Darlington Technical College Copyright © 2009 Pearson Education, Inc., publishing.

ELAINE N. MARIEB EIGHTH EDITION 10 Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings PowerPoint ® Lecture Slide Presentation by.

Why is the Circulatory System Important? 1. Transport of oxygen and carbon dioxide (why are these gases important?) 2.Transport nutrients and wastes. Sugars,

Blood. Blood  The only fluid tissue in the human body  Classified as a connective tissue  Living cells = formed elements  Non-living matrix = plasma.

Formed Elements. Includes all cellular parts of blood Includes all cellular parts of blood Composes approx. 45% of total blood volume Composes approx.

BLOOD. Our Goal Today... Describe the components of blood.

ELAINE N. MARIEB EIGHTH EDITION 10 Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings PowerPoint ® Lecture Slide Presentation by.

Blood Keri Muma Bio 6. Functions of Blood Transport  Oxygen and nutrients to the cells  Waste away from cells  Hormones Regulation  Maintain body.

LESSON 11 – HUMAN BLOOD MODIFIED BY K.RIGGINS HEWITT-’TRUSSVILLE HIGH SCHOOL ANATOMY & PHYSIOLOGY.

Hematopoiesis and Blood Clotting

PowerPoint ® Lecture Slide Presentation by Patty Bostwick-Taylor, Florence-Darlington Technical College Copyright © 2009 Pearson Education, Inc., publishing.

Hematopoiesis Blood cell formation Occurs in red bone marrow.

Bell Work How would you describe blood?

Hematopoiesis Topic 9 Blood Essentials of Human Anatomy & Physiology

Figure 17.1 The major components of whole blood.

Functions of Blood Deliver O2, nutrients to all body cells

Functions of Blood Deliver O2, nutrients to all body cells

Hematopoiesis and Hemostasis

UNIT 3 NOTES: Hematopoiesis & Hemostasis

ANATOMY Unit 3 Notes: Hematopoiesis & Hemostasis

Transportation & Circulatory System

(erythocytes = red; platelets = yellow; T-lymphocyte = light green)

Blood Disorder: Hemophilia

Presentation transcript:

Hematopoiesis & Hemostasis

(1) Hematopoiesis Blood Cell Formation Occurs in Red Bone Marrow Cell Development: Hemocytoblast (original stem cell) Lymphoid Stem Cell Myeloid Stem Cell Erythrocytes Basophils Eosinophils Neutrophils Monocytes Platelets Lymphocytes

(2) Red Blood Cell Development RBC’s have no nucleus… Synthesize hemoglobin during development Increase in hemoglobin  Eject Organelles Results in Biconcave Shape Erythropoeitin: Protein which controls rate of RBC production. Circulates in blood Targets bone marrow Produced in liver + kidney Decrease in Oxygen  Increase in Erythropoeitin

(3) Rate of RBC Production (Erythropoeitin Release  More RBC’s) Stimulus: Change in RBC count Change in Oxygen availability Change in demand for Oxygen Scenario: Decreased RBC count… Reduced Oxygen in blood Kidney releases erythropoeitin Red bone marrow stimulated RBC’s produced

(4) Hemostasis (Blood Clotting) Stimulus: Injury to blood vessel. Events: 1. Collagen fibers exposed, Platelets adhere. 2. Platelets release serotonin to constrict vessels, More platelets seek wound. 3. Thromboplastin released by damaged vessel cells. 4. PF3 (Phospholipid) binds with Thromboplastin + Calcium  BEGIN CLOTTING CASCADE!

Clotting Cascade (Prothrombin Activator): Prothrombin converted to Thrombin. Thrombin joins Fibrinogen proteins to form larger polymer (Fibrin). Fibrin forms a mesh-like trap to catch RBC’s. Vessels Constrict and ruptured edges are closed together.

Thromboplastin….

Prothrombin….

Thrombin….

Fibrinogen….

Fibrin….

Initial Injury Clotting Cascade Begins Prothrombin changed to Thrombin by Prothrombin activator Thrombin binds with Fibrinogen to form Fibrin… Finally the mesh-like net is formed to catch blood cells

(5) Thrombus vs. Embolus Thrombus  Clot in wall of blood vessel Embolus  Free Floating Thrombus Causes: Rough blood vessel tissue from burns, ruptures, fat. Slow blood flow (low levels of activity) Aspirin: Common over the counter anticoagulant.

(Hemostatic Disorder) (6) Thrombocytopenia (Hemostatic Disorder) Low platelet count & Slow Clotting Rate Typical of bone marrow cancer and/or radiation patients. Caused by damaged liver  Cannot make clotting factors.

(Hemostatic Disorder) (7) Hemophilia (Hemostatic Disorder) Low Clotting Factor Count & Slow Clotting Rate Either missing Clotting Factor #8 or #9