2010 NIAMS Scientific Retreat Comparative Effectiveness Research Institute of Medicine Priorities Functional Limitations & Disabilities Endocrinology & Metabolism Disorders Geriatrics, Pallative, & End-of-Life Care Musculoskeletal Disorders Women's Health Immune System, Connective Tissue, & Joint Disorders Skin Disorders Number of IOM Recommendations

2010 NIAMS Scientific Retreat Comparative Effectiveness Research Discussion Topics Diseases within the NIAMS mission that are ready for CER – Multiple interventions – Medical community has not agreed on the preferred treatments – Burden to society and individual patients Infrastructure needs – Cohorts – Electronic medical records Must capture patient-relevant outcomes – Standardized outcome measures – Practitioners who will practice evidence-based medicine – Mechanisms to evaluate whether CER guides patient care

2010 NIAMS Scientific Retreat Comparative Effectiveness Research Discussion Topics (Continued) Appropriate study designs – Beyond randomized clinical trials Medical records Adaptive designs – “Shared decision making” in a real-world setting Approaches to identify high-priority research questions – Collaborations and partnerships with sibling agencies and constituents Strategies to engage constituents as the NIAMS further develops its CER portfolio – Publish a Request for Information in the NIH Guide – Hold workshops or roundtables – Use social networking approaches – Tap members of the NIAMS Coalition