3D Slicer for Image Guided Therapy Program Goal: To develop general display, control, and communications modules providing a resource to support diverse IGT applications –Thermal therapies –Vascular interventions –Surgical excision Specific Aim: Provide seemless tracking for rigid tools and catheters inside and outside of MRI scanner. Enable –Dynamic Volume Acquisition –Continuous 3D Visualization –Real-time MR System Control

Tracking Systems GE InstatrakEM Tip TrackingMRI NDI PolarisPassive optical, hybrid AuroraEM IGT FlashpointActive optical Robin Medical EndoscoutEM / MRI gradient Biosense Webster CARTOEM / induction coil Ascension Bird, MicrobirdEM

Slaving of 3D Slicer Workstation Read coordinates from FDA approved system (e.g., GE Navs). FDA approved system provides primary source of information to clinician 3D Slicer provides augmented information (e.g., DTI) and will serve as a research platform.

Platforms 3D Slicer Pai Saiveroonporn – Thermal mapping, on-line scanner control Ryoichi (under Zientara grant) – Cryo iceball prediction Eigil Samset – Oslo Randy Ellis – Queens College Mike Guttmann - NIH

Interactive Scanner Control Dynamic re-sizing, re-orienting and re-positioning for rapid targeting of treated volume

1st Qtr2nd Qtr st Qtr2nd Qtr Control Console Multi-computer MRI Scanner System Adaptive Scanner Control Dynamic re-ordering and reshaping of acquisition for rapid adaptation to changes in treated volume

Flexible protocol definition to serve diverse IGT applications Temperature Visualization adjustment

Multi-planar views of treatment evolution: real-time or retrospective Anatomical Temperature Thermal Dose movie

Real-time rendering of treatment volume movie Temperature Thermal Dose TemperatureThermal Dose

Real-time Surface Visualization movie Temperature Thermal Dose TemperatureThermal Dose

Cryotherapy (Zientara) Intra-procedural 3D Assessment Real-time Monitoring and Controlling

CRYOTHERAPY – RENAL 3) Monitoring 4) Controlling 2nd 15 min Freeze

Real-time Control of 3D-Slicer Visualization using Coordinates from Electrophysiological Catheter Tracking System (Westin)

Reformatted view of the MRI volume using the location and orientation of the CARTO points.

Microscope/endoscope video registration to MR/CT Simon Warfield P01 Lighthouse Imaging SBIR, CIMIT

A Navigation System for Augmenting Laparoscopic Ultrasound (Ellsmere)

Neuro intervention (Pujol) Ascension microbird integrated into Slicer

Open tracker Developed by Technical University of Graz flexible XML based tracking framework source code available under for Windows, Irix and Linux. includes drivers for a range of different tracking systems. modules for some addition tracking systems have been developed by Samset et al. can be used to maintain registration across different tracking systems