A Web interface to cloud-based Monte Carlo simulations for TrueBeam and C-linac Good morning. I will be introduce the ‘ cloud-based Monte Carlo simulations for TrueBeam and C-linac’. Jong In Park M.S. student http://radiotherapyresearchtools.com

Contents What is the Virtual Linac Application of Virtual Linac How can we use (register) ? In this presentation, first I’m gonna talk about the backgroud of virtual linac, then I will briefly introduce the application of virtual linac Finally, I will talk about how can we use or register virtual linac

Background Let me refresh your memory on the montecarlo package provided by varian medical system. They provides phase space files for Truebeam simulation, but it has limited geometry in field-independent components Varian provides ‘just’ phase space file for TrueBeam simulation Field-independent components were not open to the public - Target, ion chamber, carousel

Purpose of Virtual Linac Varian has developed a cloud based web application, called “Virtual Linac” Linac Monte Carlo simulation as service - Enable the research community - Validated geometry (by Varian) - Fast computing is available w/o server Now updating .. Varian has developed a cloud base web application, it is called Virual Linac Aim of virtual linac is Monte Carlo simulation as service for resarch community which is insufficient computing environment And.. Important thing that the Virtual linac has validated geometry by Varian. 2013. 05. 06 version 84 (open to the public) ~ 2013. 11. 18 version 94 http://radiotherapyresearchtools.com

Simulation Mechanics Amazon Web Service User Elastic compute cloud 2 Input file Dose distribution Amazon Web service provides a various service, EC2 is a application for cloud computing. Varian design the application for run MC simulation to derive dose distribution User should type input file to EC2 application, then EC2 application return dose distribution. Run MC simulation http://radiotherapyresearchtools.com

Use Case 1 – General case Virtual Linac Check a plan DOSXYZnrc First, Monte Carlo expert wants to second check a plan, (research purpose) Dose distribution http://radiotherapyresearchtools.com

Virtual Linac Graphic User Interface This figure shows the graphic user interface in virtual Linac, Geometry of TrueBeam and Clinac was embedded in the virtual linac Can simulate the electron beam and photon beam included with fff beam After finishing type input file, click the run button, then simulation will perform and download to local computer http://radiotherapyresearchtools.com

Validation of Simulation Results Presented in ‘AAPM’ meeting This data was presented in AAPM annual meeting As shown in this figure, simulation results of virtual linac were well matched with measurement with ion chamber. - Simulation results were well matched with measurement http://radiotherapyresearchtools.com

Use Case 2 – What can we change ? Treatment head One of the use is changing the geometry and, then obtain the results. Like as General Monte Carlo simulation, we can investigate changes to the treatment head – all of the target, and limited custom target is also available Investigate changes to the treatment head Low energy, medium energy, high energy, imaging, Custom is also available http://radiotherapyresearchtools.com

Use Case 2 – What can we change ? Originally, in TrueBeam simulation Virtual Linac Can define “Target” When we simulate the TrueBeam Field independent components can not modified, because of varian confidential. However, In virtual linac We can define and change the geomtery of Target component Therefore, Varian medical system published varlidation article by replacing the carbon target for FFF beam Using carbon target

Use Case 2 – Treatment head Flattening filter - Open port (FFF), 4X, 6X, 8X, 10X, 15X, 18X, 20X Location of writing phase space file - above the jaw - below the mylar - isocenter - 95 cm from source - 150 cm from source Virtual linac has advantage for well-defined treatment head geometry. Especially, flattening filter for all photon energies and scattering foil for all electron energies So, we can change only source parameters for benchmarking When we extract the phase space file, limited locations were available such as above the jaw, below the mylar, isocenter, 95 cm and 150 cm http://radiotherapyresearchtools.com

Use Case 3 – TrueBeam Developer mode Dose distributions from TrueBeam Developer Mode XML file - non-Monte Carlo expert What exactly is Developer Mode? - A method to control all motion axes and imaging through customized XML scripts Final Interesting use is Truebeam developer mode Dose distributions from xml file can be calculated Developer mode can simulate the all motion axes and imaging by modifying the customized XML scripts ! Current motions supported Dynamic jaw resizing Collimator rotation MLC articulation Gantry rotation 4-D couch ‘kicks’ Image by Varian

Use Case 3 – TrueBeam Developer mode Still to come ! When we load xml file, virtual linac properly parsing data for simulation However, this mode is not available in current version. After the upate the developer mode, we can research a various topic changing the xml file. TrueBeam Developer mode ‘xml’ http://radiotherapyresearchtools.com

How can we use (register) ? Requirements ① Send an email to – Daren Sawkey (Varian Medical Systems) - expression of register So, how can we register as user to virtual linac application First, we send an email to Daren sawkey, he is representative of monte carlo service in Varian When we receive the answer to email.

How can we use (register) ? Requirements ② IP address as seen by the outside world (google “what’s my ip”) We investigate the ip, because of virtual linac is private application. So access right is limited to permitted user

How can we use (register) ? Requirements ③ Amazon Web services account number You can sign up for the Amazon Web Services (AWS) at aws.amazon.com. After the sign up, click my account Cloud service MC is based on the Amazon web service So, we need the account number, after the sign up account number, we should mail the this number and ip address Finally, we can get right access to the virtual linac! The AWS documentation is great, and available at aws.amazon.com/documentation/ec2 for EC2.

How can we use (register) ? Requirements ④ A completed license agreement And then we must sign license agreement Eligible person who has the power and authority to execute this agreement on behalf of institution. And..in documents, When we publishing the results for publication or presentation, we need to review the draft copy by Varian at least 45 days prior to presentation or publication date He or she has the power and authority Varian the opportunity to review a draft copy of the proposed publication or presentation for review and approval at least 45 days prior to..

How can we use (register) ? Once the register, you can get started - Log in to AWS After the obtaining the right access, we can use Virtual linac and research

How much is it? Payment ! When ? Between Amazon web service and users - Running the instance (Table) - Data transfer On-demand instance However, it is not a cost-free tools When the running the instance, data trasfer and storage on the instance cause to cost ! If we use On-demand instance – cost is burdensome.. Cost-effective instance is.. Linux based is more appropriate in point of cost, and we can more save cost by using ‘spot request’ It defines the maximum cost per hour, then instance is selected by bid. It’s calculation speed isn’t stable. But, never happened loss of information. It is fairy good choice for using virtual linac Unit: $ “Linux” is cheaper than “window” Can save cost reduced to 1/10 by using ‘spot request’ (highly recommend)

Summary Varian validated geometry of component - Full TrueBeam simulation is available Fast parallel computing TrueBeam developer mode will be soon Reasonable cost with ‘spot request’ More detail information http://radiotherapyresearchtools.com

Thank you for your attention !