A Genomic Approach to Two Related Human Scourges Scott Harrison, Mary Spratt, & John Ferguson

Introduction (This could be a library project.)

Leprosy Symtomology

Unknown boy with tuberculoid leprosy, patient of Dr. Sherwell. Born in the West Indies. Improved under treatment but died of an intercurrent disease. Photograph by O. G. Mason, the in-house photographer at Bellevue Hospital during the late 1800's. Cabinet of Art and Medicine eprosy.html eprosy.html

Lepromatous leprosy showing heaviest infiltrations of skin over the central portion of the face and ears. The eyebrows are lost. Figure 41-9 from Meyers, Wayne M. Leprosy. Chapter 41 of Guerrant, Richard L., David H. Walker, & Peter F. Weller. Tropical Infectious Diseases: Principles, Pathogens, & Practice. Philadelphia: Churchill Livingstone, 1999, pp. 474–485.

Sometimes the symptoms can be totally disfiguring A man with nodules on his face as the result of lepromatous leprosy. From University of South Carolina. MicrobeWiki, Kenyon College. dex.php/Mycobacterium dex.php/Mycobacterium

Leprosy Causative agent: Mycobacterium leprae

Gerhard Henrik Armauer Hansen. Fot. av Otto Borgen, Bergen adm/ghah.htm adm/ghah.htm

Lepromatous leprosy. The dermis is largely replaced by foamy macrophages containing large numbers of acid-fast bacilli (inset). There is a distinct subepidermal clear zone. Figure from Meyers, Wayne M. Leprosy. Chapter 41 of Guerrant, Richard L., David H. Walker, & Peter F. Weller. Tropical Infectious Diseases: Principles, Pathogens, & Practice. Philadelphia: Churchill Livingstone, 1999, pp. 474–485.

Mycobacterium leprae. © National Hansen's Disease Museum. SpektrumDirekt.

Leprosy Treatment: Multidrug therapy

Multibacillary leprosy before (a) and after (b) multidrug therapy. Figs & from Leprosy Group, WHO. Leprosy. Chapter 59 in Cook, Gordon C., & Alimuddin I. Zumla. Manson's Tropical Diseases. 21 st ed. Saunders, 2003, pp. 1065–1084. ab

Leprosy Epidemiology: Disappearing!

Leprosy History?

Tuberculosis Symptomology

These chest x-rays show advanced pulmonary tuberculosis. There are multiple light areas (opacities) of varying size that run together (coalesce). Arrows indicate the location of cavities within these light areas. The x-ray on the left clearly shows that the opacities are located in the upper area of the lungs toward the back. The appearance is typical for chronic pulmonary tuberculosis but may also occur with chronic pulmonary histiocytosis and chronic pulmonary coccidioidomycosis. MedlinePlus Encyclopedia, US National Library of Medicine, National Institutes of Health

Tuberculosis Causative agent: Mycobacterium leprae

Mycobacterium tuberculosis. Scanning electron micrograph. Laboratory of Immunogenetics, Tuberculosis Research Section bs/lhd/barry.htm bs/lhd/barry.htm Mycobacterium tuberculosis. Light micrograph. fcomte.fr/bacterio_web/exa_microscopiques /mycobacteries/Mycobacterium_tuberculosi s_cordes_Ziehl.htm fcomte.fr/bacterio_web/exa_microscopiques /mycobacteries/Mycobacterium_tuberculosi s_cordes_Ziehl.htm

Mycobacterium tuberculosis in lung, Ziehl-Neelsen acid fast stain. Spencer S. Eccles Health Sciences Library, University of Utah Health Sciences Center, University of Utah.

Tuberculosis Treatment: Multidrug therapy (But multidrug resistant and extremely drug resistant strains!)

Tuberculosis Epidemiology: Not disappearing

Tuberculosis History?

Questions

Module #1 How do the genomes differ at a more macroscopic level?

Module #2 How do two genes differ in both structure and context?