ENG Advisory Committee May 11, 2005 BES OVERVIEW Bruce Hamilton Acting Division Director

BES Structure & Funding Profile Three (3) Clusters: –Biochemical Engineering/Biotechnology (BEB) –Biomedical Engineering/Research to Aid Persons with Disabilities (BME/RAPD) –Environmental Engineering and Technology (EET) Each cluster is funded at about 1/3 of BES’s overall budget (~ $50 million/year)

BES Team Program Officers: Pat BrezonikGil Devey (PT) Fred Heineken Lenore Clesceri (PT)Cindy Ekstein Marshall Lih Semahat DemirLeon Esterowitz Tom Waite Mike Domach (PT)Bruce Hamilton (ADD) Bill Weigand (PT) Support Staff: Toni BakerLaWanda Prailow Sherri Swann Eula PattersonMarcia RawlingsLaTanya Darby Sunny PhelpsJoyce Simpson

BES Draft Vision An Aspiration for the Future... BES is an important and significant Catalytic Driver for the role of Biology and the Environment in advancing the Frontiers of Engineering research, innovation, and education.

Why the Role of BES Is As a Catalytic Driver: 1. Resources needed. 2. At NSF, the involvement of Engineering with Biology and the Environment has become pervasive, going way beyond BES.

Biology: All 6 NSF ENG Divisions Support Biology-Oriented Awards BES: All aspects of biology and engineering CMS: Biomechanical Eng (e.g., bone biomaterials) CTS: Biotransport Eng (e.g., blood flow fluid dynamics) DMII: Engineering Health Care Delivery ECS: Many aspects of biology and engineering (e.g., biomedical imaging) EEC: Centers, Dept. Reform (biology and engineering)

CISE Directorate Also Supports Engineering/Biology-Oriented Awards Example-- ITR : “Simulation-Based Medical Planning for Cardiovascular Disease” PI = Charles Taylor Department of Bioengineering Stanford University $3.7 million over 5 years

EHR Directorate Also Supports Engineering/Biology-Oriented Awards Example (undergraduate course): NSF “Development of Educational Materials that Strengthen Students’ Problem-Solving Skills for a Bioengineering Fundamentals Course” PI = Ann Saterbak Rice University $75K over 2 years

And for the case of the Environment: Just as for the pervasiveness of Biology in Engineering, so also for the pervasiveness of the Environment in Engineering. (goes way beyond BES, therefore the role of BES as Catalytic Driver is appropriate)

BES Draft Mission Research and Innovation: Enable and facilitate the deployment of new innovations in BES’s fields in service to society for use in the medical, biotechnology, and environmental arenas Education: Advance bioengineering and environmental engineering through the development of creative programs by new and diverse faculty (example: Emphasis on CAREER awards, including under-represented group PECASE awardees)

BES Strategies To pursue our Vision and Mission, BES has evolved 7 Key Strategies (Time to cover only 4)

BES Strategy #1 Develop and support the best and the brightest researchers, innovators, & educators in BES’s fields, with one emphasis being on new faculty

BES Strategy #1: Develop and support the best and the brightest researchers, innovators, & educators in BES’s fields, with one emphasis on new faculty. Examples: 2004 Waterman Award Winner: Kristi Anseth (1998 BES CAREER awardee) Waterman Award Winner: Chaitan Khosla (1994 NSF Young Investigator awardee from BES) IOM Inductees: Cato Laurencin (BES PI from early in career) and Frances Arnold (1989 BES PYI; also NAE in 2000) HHMI $1 Million Undergraduate Educator Award Winner: Rebecca Richards-Kortum (1991 BES PYI) NAE Draper Award and 1998 Lemelson Invention Prize Winner: Bob Langer (long-time BES PI, starting early in his career) NAE Inductee (Industrial Ecology): Tom Graedel (BES is principal source of support, starting early in his academic career) 2005 NAE Inductees: George Georgiou (1987 BES PYI) and Harvey Blanch (long-time BES PI). Future Goal: Develop and support more winners!

BES Strategy #2 Aggressively pursue and implement partnerships with other ENG divisions, directorates, and agencies, even if tolerance of high risk is required (e.g., solicitation risk)

BES Strategy #2: Aggressively pursue and implement partnerships with other ENG divisions, directorates, and agencies. Examples: Metabolic Engineering: NSF, NIH, DOE, EPA, NASA, NIST, DOD, USDA MATES: NSF, NIH, NIST, DOD, FDA, DOE, NASA QSB: ENG (5 divisions), BIO, MPS, CISE. Biophotonics: NSF, NIH, DARPA. Multiscale Bio Modeling: NSF, NIH, NASA, DOE. CRCNS: ENG (BES, ECS), CISE, BIO, SBE, NIH. MUSES: ENG (5 divisions), SBE, CISE, MPS IGI: ENG (BES, ECS), CISE, NIH, NASA Forum on the Interface of the Life Sciences and Physical Sciences: NSF, NIH, NASA, NIST, DOE, USDA, EPA, DOD, FDA, NOAA Future Goal: Additional innovative partnerships with high-return leverage.

BES Strategy #3 Dynamically interact, through extensive outreach, with universities, industry, foundations, non-profits, other agencies, and professional societies and topical meetings.

BES Strategy #3: Dynamically interact, through extensive outreach, with universities, industry, foundations, non-profits, other agencies, and professional societies and topical meetings. Examples: Universities: Workshops (e.g., for CLEANER, at Stanford, U. of Minn., Duke, U. of Iowa, RPI) Industry: BES Biochemical Engineering Workshop (Amgen, Biogen, Chiron, Genencor, Genetics Institute, engeneOS Biosystems, Inc.) and 2005 Metabolic Engineering Conference with industry. Foundations: Whitaker, HHMI. Non-profits: MdBio, Inc., the National Academies. Professional Societies: AIChE, ACS, IEEE, BMES, AIMBE, AEESP, WEF, ASEE, SWE, WEPAN and others. Future Goal: Strengthen outreach, with high-return (intellectual, financial, diversity).

BES Strategy #4 Create and implement “Big Ideas.”

BES Strategy #4: Create and implement “Big Ideas.” Examples: - CLEANER - Engineering Systems Biology - Biophotonics (BP) / IGI Future Goals: - Implement CLEANER, include other agencies. - Extend QSB and include other agencies. - Grow BP / IGI partnership with other agencies.

BES Draft Vision An Aspiration for the Future... BES is an important and significant Catalytic Driver for the role of Biology and the Environment in advancing the Frontiers of Engineering research, innovation, and education.