Antibody and B cell responses may control circulating lipopolysaccharide in patients with HIV infection Lim A 1, Amini A 1, D’Orsogna L 2, Rajasuriar R.

Slides:

Advertisements

Similar presentations

If this is malaria, what are the probable reasons for this patient to have another episode of malaria?

Advertisements

Developing Immunotherapy for Autoimmune Diseases

An epidemic in transition: impacts of migration and local networks on HIV sequence diversity and infection transmission in Australia

High rates of survival, virologic suppression and immune reconstitution among patients receiving second-line ART in the Indian national programme B.B.

Levels of IL-18, sCD14, CCL2, CXCL8 and CXCL10 in tubercular immune reconstitution inflammatory syndrome in a North Indian population Manoj Kumar 1, Patricia.

Should we treat HIV Controllers ? IAS 2013 Pr Olivier Lambotte Department of internal medicine and clinical immunology Bicêtre Hospital, University Paris.

Natural control of HIV infection is associated with an isotype switched IgG antibody response to HIV Gag antigens in patients with 'non-protective' HLA-B.

Virologic and immunologic response following antiretroviral therapy initiation among pregnant and postpartum women with acute HIV-1 infection: MOPDB0101.

Antibody structure Heavy chain constant region determines antibody class.

Preventing HIV/AIDS There is no way to tell just by looking whether a person is infected with HIV. Because people are unaware that they are HIV-positive,

Managing Infection Risk in Primary Systemic Vasculitis Patients Dr Matthew Morgan University of Birmingham.

Blood July 15; 106(2): 572–576. Role of molecular mimicry to HIV-1 peptides in HIV-1–related immunologic thrombocytopenia Zongdong Li, Michael A.

Immune correlates of unusual control of viral replication after cessation of HAART Ellen Van Gulck 1, Leo Heyndrickx 1, Céline Merlin 1, Sandra Coppens.

Basics of Immunology.  Immunology is the study of the ways in which the body defend it self from infectious agents and other foreign substances in its.

DIAGNOSIS OF HIV INFECTION THE LABORATORY BY DR. K.BUJJIBABU.MD.

Detecting Infectious HIV in Human Milk Miles W. Cloyd, Ph.D. Professor Department of Microbiology & Immunology University of Texas Medical Branch Galveston,

Clinical and mycological determinants of Cryptococcosis-associated IRIS (C-IRIS) Chang CC, Elliott JE, Gosnell BI, Dorasamy AA, Omarjee S, Naranbhai V,

Absolute CD4+CD25+CD127low/- T Cells (Treg) in Peoples with HIV/AIDS

P-CID patient discussion form. Patient summary y/o boy/girl with: – Infection – Immune dysregulation – T cell deficiency Consanguinity: Family history:

Avidity determination of IgG in diagnosis of tick-born encephalitis Hana Zelená Jiří Januška Jan Raszka Virology department, National Reference Laboratory.

Highlights of Immune System. Topic Outline Overview of the Immune System 1 st and 2 nd lines of Defense The Immune System  B cells  The antibody & antibody.

The case for HIV testing A presentation for the clinical team in your practice.

Immunology. Purpose of the immune system: –Discriminate self from non-self Non-self –Antigens Immunity: –All mechanisms used by the host to protect itself.

Potential Utility of Tipranavir in Current Clinical Practice Daniel R. Kuritzkes, MD Director of AIDS Research Brigham and Woman’s Hospital Division of.

Chapter 17 Immune response. Two types of resistance. Innate resistance and acquired resistance. Innate resistance – one is born with the resistance. All.

The Humoral (B cell) Immune Response. Linked Recognition.

Antigens Immunogen – a molecule that specifically interacts with an antibody or lymphocyte and elicits an immune response Antigenic determinants (epitopes)

IgM ELISA CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY Jan. 1998, p. 7–10 Vol. 5, No. 1 Copyright © 1998, American Society for Microbiology.

11. B Cell Recognition and Response to Antigens 王家鑫王家鑫.

Lecture 7 Immunology Cells of adaptive immunity

Routine vaccination and maintenance of serological memory in HIV infected children Moderators: Berhanu Gudeta, Ethiopia Francesca Chiodi, Sweden Cell Damage.

HAART Initiation Within 2 Weeks of Seroconversion Associated With Virologic and Immunologic Benefits Slideset on: Hecht FM, Wang L, Collier A, et al. A.

Lecture 6 Humoral Immune Response. The Antibody Response.

Gastrointestinal and liver diseases

Anti-IgA antibodies: Risks and safety of immunoglobulin substitution

From: Parvovirus B19–Related Anemia in an HIV-Infected Patient: Rapid Control after Production of Neutralizing Antibodies during Highly Active Antiretroviral.

Fluorescent antibody test

Table 1 Diagnosis and clinical status of patients co-infected with HIV and Trypanosoma cruzi at the beginning of the study From: Long-term follow-up of.

Dominant IL-21 expression in TFH cells correlate with B cell pathology in HIV-infected LNs. Dominant IL-21 expression in TFH cells correlate with B cell.

Establishment of human IgE system in severe combined immunodeficient mice with peripheral blood mononuclear cells from asthmatic children Bor-Luen Chiang,

The Aging Liver in the Aging HIV and HCV Patients

Chlamydia pneumoniae in HIV-infected patients and controls assessed by a novel whole blood interferon-γ assay, serology and PCR I.J. Woolley, M. Larsen,

J. P. Routy1, V. Mehraj1,, R. Ramendra1,, C. Costiniuk1,, B

ESID Prague Spring Meeting 2009

Chapter 17 Immune response.

Humoral Immune Reconstitution Kinetics after Allogeneic Hematopoietic Stem Cell Transplantation in Children: A Maturation Block of IgM Memory B Cells.

Heterozygous signal transducer and activator of transcription 3 mutations in hyper-IgE syndrome result in altered B-cell maturation Almut Meyer-Bahlburg,

The clonal selection model of immunogenesis

Chlamydia pneumoniae in HIV-infected patients and controls assessed by a novel whole blood interferon-γ assay, serology and PCR I.J. Woolley, M. Larsen,

HCV treatment with direct-acting antivirals (DAAs) in HIV/HCV coinfected subjects affects the dynamics of the HIV-1 reservoir Y. Ghiglione1, M.L. Polo1,

Chronological evolution of IgM, IgA, IgG and neutralisation antibodies after infection with SARS-associated coronavirus P.-R. Hsueh, L.-M. Huang, P.-J.

Heterotaxy syndrome with and without spleen: Different infection risk and management Eva Piano Mortari, PhD, Anwar Baban, MD, PhD, Nicoletta Cantarutti,

CD4+CXCR5+IL-4+ TFH cells and CD4+IL-4+BATF+ T cells are enriched in IgG4-RD, and their proportions are tightly linked to serum IgG4 levels and IgG4-positive.

IgM Memory Cells: First Responders in Malaria

Prevalence of Yersinia plasmid-encoded outer protein (Yop) class-specific antibodies in patients with Hashimoto's thyroiditis S. Chatzipanagiotou, J.N.

White Blood Cells Immune System.

CXCR5+/+ TFH cells are dispensable for maintenance of the LCMV-specific antibody response. CXCR5+/+ TFH cells are dispensable for maintenance of the LCMV-specific.

M. Korva, A. Saksida, N. Kejzar, C. Schmaljohn, T. Avŝiĉ-Zupanc

Volume 72, Issue 3, Pages (August 2007)

Ricardo U. Sorensen, MD, Luke A. Wall, MD

Supplemental Figure 1 Patient 2.

Recurrent Clostridium Difficile

Factors related to the chronicity and evolution of hepatitis C infection in patients coinfected by the human immunodeficiency virus R. Pérez-Cano, C.

29. Immunization Journal of Allergy and Clinical Immunology

C.P. Kelly Clinical Microbiology and Infection

Third Line of Defense Immune Response (Specific Defense)

III Meeting Neuroscienze Toscane

Usa Tantibhaedhyangkul, MD, Carla M. Davis, MD, Lenora M

Innate immune defects correlate with failure of antibody responses to H1N1/09 vaccine in HIV-infected patients Suresh Pallikkuth, PhD, Sudheesh Pilakka.

Introduction to Microbiology

Presentation transcript:

Antibody and B cell responses may control circulating lipopolysaccharide in patients with HIV infection Lim A 1, Amini A 1, D’Orsogna L 2, Rajasuriar R 3, Lewin S 3,4, Purcell D 5, Price P 1, French MA 1,2 1. School of Pathology and Laboratory Medicine, University of Western Australia 2. Department of Clinical Immunology, Royal Perth Hospital, Perth 3. Alfred Hospital, Melbourne 4. Monash University, Melbourne 5. Department of Microbiology and Immunology, University of Melbourne

Marginal zone (IgM + memory) B cells and IgA antibodies respond to gut microbial products Cerutti A, Rescigno M. Immunity 2008; 28: Kraal G. Nature Immunol 2008; 9:11-12

Plasma levels of LPS are inversely correlated with serum levels of antibodies to LPS in ART-naïve HIV patients

LPS-specific IgG antibodies correlate with IgM + memory B cell counts in ART-naïve patients

Better immune reconstitution on ART is associated with lower plasma LPS and serum anti-LPS

Summary In ART-naïve patients: Serum levels of IgG and IgA antibodies to LPS are negatively correlated with plasma LPS levels Serum levels of IgG anti-LPS are positively correlated with circulating IgM + memory B cell counts Serum IgA levels are strongly correlated with serum levels of IgA antibodies to LPS In ART-treated patients: Better immune reconstitution (higher CD4 + T cell and switched memory B cell counts) is associated with lower levels of LPS and antibodies to LPS

Conclusions Plasma LPS levels in ART-naive HIV patients may be determined by immune responses against LPS, as well as by increased gut permeability High serum IgA levels in untreated HIV infection may reflect an IgA antibody response against LPS