1 Winning at Weight Loss Fatless ®

2 Carbohydrates and Weight Gain Carbohydrate consumption has increased over the years as fat intake has decreased. Obesity and diabetes rates have risen along with carbohydrate consumption. A typical Western diet provides: – g carbohydrates/day – calories –49% of total calories from carbohydrates Blocking the conversion of carbohydrates into glucose can reduce fat storage and promote weight loss.

Fatless ® 3 “Potatoes, eaten in large quantities by a population increasingly sedentary and overweight, may be a major contributor to America’s alarming rates of heart disease and diabetes.” Time Magazine, Jan. 21, 2002 “10 Foods That Pack A Wallop”

Fatless ® 4 “This is not just a potato problem. It’s also a problem with white bread, bagels, and most white rice.” Time Magazine, Jan. 21, 2002 “10 Foods That Pack A Wallop”

Fatless ® 5 Carbohydrates and Weight Gain Pancreas produces alpha amylase, a starch-digesting enzyme Alpha amylase converts starch into glucose (sugar) Sugar calories are burned or stored as fat cells Stomach Pancreas Liver Small Intestine

Fatless ® 6 Foods Containing Starchy Carbohydrates Potatoes Pasta Bread Rice Grain Refined and processed grains have a high glycemic index

Fatless ® 7 Health Risks of Obesity Hypertension Hyperlipidemia Coronary Artery Disease and Stroke Type 2 Diabetes Respiratory Disease (sleep apnea) Osteoarthritis Gallbladder disease Cancer (breast, prostate, colon) Premature Death!

Fatless ® 8 Why Is The Incidence Rising? Lack of physical activity Poor dietary choices (convenience foods) –Fast food, processed food, and sugar rather than whole grains and vegetables Increased caloric intake –Increased consumption of grains, soft drinks (sugar) and alchohol 1 Center for Nutrition Policy and Promotion, USDA, 2001

Fatless ® 9 Many People Need A Kick Start Lifestyle Coach Dietitian Nutritional Supplements Prescriptions Drugs (for severe cases)

Fatless ® 10 The first clinically studied starch neutralizer Standardized extract made from a portion of the white kidney bean Fatless® may bind with alpha amylase, “neutralizing” starch calories and preventing the conversion into glucose (sugar)

Fatless ® 11 In Vitro Studies One gram of Fatless® will “neutralize the starch calories of 1 lb. pasta or 1 loaf bread High Activity Fatless® : 5,000 – 6,000 units/g Non-standardized bean "starch blocker”: units/g No trypsin/protein inhibitor activity detected Survives undiluted gastric and intestinal solutions (68-80% retention of activity)

Fatless ® 12 Human Studies 1. “In Vivo Effectiveness of a Starch Absorption Blocker in a Double-Blind Placebo-Controlled Study with Normal Human Subjects.” Joe A. Vinson, PhD, University of Scranton, September/ “In Vivo Effectiveness of a Starch Absorption Blocker in a Double-Blind Placebo-Controlled Study with Normal College-Age Subjects.” Joe A. Vinson, PhD, University of Scranton, November/ “Evaluation of the Safety and Efficacy of a Food Supplement for Weight Control Through the Reduced Calories Intake from Carbohydrates vs Placebo (Double Blind Test).” Dr. R. Ballerini, EVIC Italia, November/ “Dose-Response Pilot Study of PHASEOUT efficacy as an inhibitor of glucose absorption with a Full Meal.” Joe A. Vinson, PhD, University of Scranton, May “Phaseolamin 2250™ (Phaseolus vulgaris) for the Treatment of Obesity.” Jay Udani, MD, Northridge Hospital, “Dose Response Human Study of Amylase Inactivator with Normal Subjects Given a Full Meal.” Joe A. Vinson, PhD, University of Scranton, 2002

Fatless ® subjects, ages (male & female, 5-15 kg overweight, stable for 30 days prior to study) Double-blind, placebo-controlled study for 30 days Recommended diet with daily consumption of complex carbohydrates during one of the principal meals Experimental: Placebo plus 500 mg of a Fatless® containing product. Changes in weight; fat and lean body mass (bioelectric impedance); waist, hip, and thigh circumference Dr. R. Ballerini, EVIC, Milan, Italy, November/2001 Weight Loss Study

Fatless ® 14 Results – Ballerini Study Fatless® Placebo Weight-2,933 kg kg lbs-0.76 lbs -3.96% TBW-0.47% TBW Fat Body Mass-10.45%-1.30% Lean Body Mass0.0% Hip Circumference-1.39%-0.10% Thigh Circumference-1.44%-0.39% Waistline Circumference-3.44%-0.53%

Fatless ® 15 NORTHRIDGE HOSPITAL Randomized, Double-Blind, Placebo Controlled 50 Patients –Obese (35 > BMI > 30) –Age < 50 –Based on Statistical Effect Size Calculation 8 week active study 1500mg of Fatless ® or Placebo Approved by Human Use and Research Committee

Fatless ® 16 Overall Results Fatless® 3.8 pounds 1.5 inches off waist 26 point drop TG 13%  energy Reduced hunger Placebo 1.1 pounds No loss of inches 8 point drop TG No effect on energy or hunger

Fatless ® 17 Natural, standardized extract with the first demonstration of effectiveness in human studies Safe, non-stimulant carbohydrate control mechanism that blocks carbohydrate conversion to sugar calories Reduces starch absorption by an average of 57% Produces weight loss by reduction of body fat mass No known adverse side effects or drug interactions Reasonable effective doses (500-1,500 mg/meal) Summary

18 The bottom line… Healthy eating and physical activity are essential for weight management.