Toxicity Interactions In Anagrams InfectionsPregnancy Pharmaco- Genomics

PHOTOS Long term use of this drug can cause macular damage and bluish discoloration of the skin.

Hydroxychloroquine

Baseline and q 3 mo LFTs and CBC, a baseline chest x-ray and Hep B and C screen are recommended prior to starting this drug.

Methotrexate

The use of this medication to replace cyclosporin has helped lessen the incidence of hyperuricemia and gout among transplant patients.

Mycophenolate mofetil

Use of cyclophosphamide can lead to this kind of cancer

Bladder Cancer

PHOTO Defieciency in this immunoglobulin can lead to severe anaphylactic reactions in patients receiving IVIG. Check it before the patient receives it.

IgA

The dose of Azathioprine should be decreased by 50% when a male patient with tophi is also taking this drug. POUR LION ALL

Allopurinol

This neurotransmitter is the target of a class of antidepressants which when taken with NSAIDs can greatly increase the risk of GI bleeding by 30-50%. NOTE IRONS

Serotonin

Even a 3-day course of Naproxen can decrease the protein binding of this drug which notoriously has a very low therapeutic index, greatly increasing the risk of GI hemorrhage. FAIR WARN

Warfarin

The use of a commonly used class of antidepressants can greatly diminish the analgesic effect of this pain medication by inhibition of CYP2D6. DRAMA LOT

Tramadol

Cyclosporine inhibits organic anion transporting polypeptide (OATP) transporters, a family of influx transporters, which is the substrate for a commonly used lipid-lowering agent which has also been implicated in causing myopathy. VITAMINS SAT

Simvastatin

A patient who works in a hospital and nursing home who develops septic arthritis or bursitis should be started on this antibiotic.

Vancomycin

Use of Rituxan has been associated with this kind of infection due to the JC Virus

Progressive multifocal leukoencephalopathy

Of Hepatitis B or C, the use of Rituximab should be used with great caution.

Hepatitis B

Of Infliximab, Abatacept, and Rituximab, reactivation of this infection can is strongly associated with the use of this biologic agent.

Tuberculosis

This condition should be considered in an RA patient from Arizona on a biologic agent who develops fevers, cough and lung lesions.

Coccidiodomycosis

Patients who have been on Leflunomide who are seeking to conceive should receive this medication in order to rid the body of the medication

Cholestyramine

Of A, B, C, D – the FDA pregnancy category for Hydroxychloroquine

B

This is the FDA Pregnancy category for Methotrexate.

Class D

Of 20%, 40%, 60% - the approximate percentage of fetal deaths that can occur with usage of Mycophenolate mofetil

40%

Fetal loss can be prevented in women with this disease by using SQ Heparin.

Antiphospholipid Antibody Syndrome

Alterations in P450 3A activity in liver, especially CYP3A4 and CYP3A5, and intestinal P-glycoprotein (P-gp) concentration are important factors in the metabolism of this drug.

Cyclosporin

Reduced activity of this enzyme can cause increased GI side effects and hepatotoxicity, lupus- like syndromes and cutaneous vasculitis with patient taking sulfasalazine. It is the same enzyme that metabolizes Isoniazid.

Sulfasalazine

The risk for GI hemorrhage with use of celecoxib, diclofenac, indomethacin, naproxen and piroxicam is associated with activity of this cytochrome.

CYP2C9

Talk about the 40s! There is a 40% incidence of deficiency in this enzyme which metabolizes Methotrexate; a CT heterozygote for the C677T genotype is found in 40% of the population is associated with a 40% inability to regenerate one of the elements in the metabolic pathyway.

Methyltetrahydrofolate reductase

Deficiency in this enzyme can lead to leukopenia in patients taking Azathioprine PLEASE ReFUSE HIM THe TYRANNY RIOT LR

TPMT or Thiopurinylmethyltransferase