Optics of Refractive Procedures Amy C. Nau, OD, FAAO Clinical Optics 3 rd edition, Elkingtpon, Frank and Greaney

Ways to alter the refractive state of the eye Ways to alter the refractive state of the eye –Change the refractive power of any media –Change the depth of the AC –Change in the axial length of the eye

Outline Surface Surface –Cornea –Excimer laser PRK PRK Lasik Lasik Lasek Lasek PTK PTK –Incisional AK AK PK (DLK etc) PK (DLK etc) RK RK –Other CK CK Intacs Intacs orthokeratology orthokeratology Invasive Invasive –Lens Clear lens extraction Single vision Multifocal Accommodating Phakic –Silicone Oil

Corneal approach v Lens approach Majority of power occurs at the air/tear interface Majority of power occurs at the air/tear interface –F air =50, F water 5D Corneal surgery functionally “limited” +4 to -10D Corneal surgery functionally “limited” +4 to -10D Second most powerful is the lens Second most powerful is the lens –Accommodation eliminated Unless multifocal or accommodating Unless multifocal or accommodating –Does not eliminate corneal astigmatism Problem : predicting residual RX from lent/corneal cyl pt. Problem : predicting residual RX from lent/corneal cyl pt.

Predicting residual refraction Rx: x 180 K: Question: when you implant a distance only IOL, what will be the predicted residual refractive error? What will be the patients expected visual acuity? What are some ways that you can take care of this for the pt? How would you counsel them during the pre-operative visit?

Basic Considerations for good refractive outcomes- Consequences of creating anisometropia Consequences of creating anisometropia is the fellow eye being operated upon? If so, when? IOL for MV- please check the dominant eye!! IOL for MV- please check the dominant eye!! Unlikely to tolerate 2.50 D of anisometropia Unlikely to tolerate 2.50 D of anisometropia –Some pts cannot wear contact lenses… Think about stereo/ occupational considerations. Think about stereo/ occupational considerations. Don’t have to make them emmetropes Don’t have to make them emmetropes 50% of pts unable to adapt to MV- 50% of pts unable to adapt to MV- Undercorrect myopes if unsure, they are used to taking off their glasses for near- cannot stand to be hyperopic…. Undercorrect myopes if unsure, they are used to taking off their glasses for near- cannot stand to be hyperopic….

Basic Considerations for good outcomes Make sure refraction and topography are stable and accurate Make sure refraction and topography are stable and accurate –Check old glasses/ cl Rx if unsure –Peds pts- notoriously difficult RGP’s may take 15+ weeks to baseline RGP’s may take 15+ weeks to baseline Soft cls if EW may take 5-10 weeks. Soft cls if EW may take 5-10 weeks. Many persons will complain loudly or go elsewhere – let them go… Many persons will complain loudly or go elsewhere – let them go…

Outline Surface Surface –Cornea –Excimer laser PRK PRK Lasik Lasik Lasek Lasek PTK PTK –Incisional AK AK PK (DLK etc) PK (DLK etc) RK RK –Other CK CK Intacs Intacs Invasive Invasive –Lens Clear lens extraction Single vision Multifocal Accommodating Phakic –Silicone Oil

Corneal Correction- general principles –Myopia: corrected by reducing the refractive power of the cornea (making it flatter) –Hyperopic and presbyopic correction must increase the refractive power of the cornea (making it “steeper” ) F=n’-n/r F=n’-n/r

Hyperopic correction Ablate tissue peripherally, making the central cornea “steeper” Ablate tissue peripherally, making the central cornea “steeper” –Less predictable –More aberrations –Custom preferred over traditional –Try CK…

Excimer Laser- PRK, Lasik, Lasek, PTK Excimer laser= “excited dimer” Excimer laser= “excited dimer” Two atoms form a pseudo molecule in the excited state by adding electric energy but dissociate into the ground state. Two atoms form a pseudo molecule in the excited state by adding electric energy but dissociate into the ground state. Argon (inert)-Fluorine (reactive) dimer emits 193nm UV radiation. Argon (inert)-Fluorine (reactive) dimer emits 193nm UV radiation. The cornea absorbs UV, so intraocular penetration is greatly reduced. The cornea absorbs UV, so intraocular penetration is greatly reduced. Each photon has 6.4eV, sufficient to break intramolecular bonds Each photon has 6.4eV, sufficient to break intramolecular bonds

Excimer Laser Delivery of high energy to small area causes tissue removal Delivery of high energy to small area causes tissue removal –(ablation/disintigration) The temperature is very high, but the amount of heat produced is small, minimizing collateral damage. Absorbed in first nanometer of tissue. The temperature is very high, but the amount of heat produced is small, minimizing collateral damage. Absorbed in first nanometer of tissue. USED for PRK, Lasik, Lasek,PTK (phototherapeutic keratectomy) USED for PRK, Lasik, Lasek,PTK (phototherapeutic keratectomy)

Excimer Broad beam- traditional lasik Broad beam- traditional lasik Scanning Slit- Nidek EC allows more tissue removed from center than periphery (or vice versa) Scanning Slit- Nidek EC allows more tissue removed from center than periphery (or vice versa) Flying Spot Flying Spot –Laser system including a laser bean delivery system and eye tracker responsive to movement of the eye. Shots are fired in a sequence and pattern such that no laser shots are fired in a consecutive location and no consecutive shots overlap. The pattern is a response to the movement of the eye. –

PRK Each laser pulse ablates surface tissue to a dept of.4-.5 microns Each laser pulse ablates surface tissue to a dept of.4-.5 microns Diameter of the laser is 1-7mm (controlled by apeture) Diameter of the laser is 1-7mm (controlled by apeture) –Haloes if apeture is 3.5-4mm Alphagan, pilo, artificial pupil contact lens Alphagan, pilo, artificial pupil contact lens –6-7mm is better, but need to ablate more cornea

PRK To correct myopia, successive concentric applications of increasing diameter are made (traditional broad beam) To correct myopia, successive concentric applications of increasing diameter are made (traditional broad beam) –More tissue ablated centrally than peripherally “terraced” profile will result in an increase in higher order aberrations

PRK For higher myopia, make more rings and try to smooth out the junctions For higher myopia, make more rings and try to smooth out the junctions –Still, less predictable outcome, more likely to regress and higher risk of scarring

Lasik Same profiles as PRK Same profiles as PRK –Less scarring, regression, earlier stabilization, better predictability Formula for figuring out if sufficient thickness exists- must do for the wavescan data Don’t use pachy- orbscan or pentacam is better (pentacam probably best)

Larger refractive errors have greater chance of scarring. Larger refractive errors have greater chance of scarring. Lasik is like a scl, will correct for both internal and lenticular astigmatism. Lasik is like a scl, will correct for both internal and lenticular astigmatism. What power to consider for MV? – 2.50? 1.50 (probably better). Leaves margin for hyperopic outcome. Which eye to do first? What power to consider for MV? – 2.50? 1.50 (probably better). Leaves margin for hyperopic outcome. Which eye to do first?

Custom Lasik

Visx- CustomVue Overview WaveScan WaveFront system and Star S4 Eximer WaveScan WaveFront system and Star S4 Eximer Acquire- fourrier analysis /psf Acquire- fourrier analysis /psf Design- using Wavescan software Design- using Wavescan software Align- Iris Registration ensures delivery of tx to proper corneal site, well centered in spite of hippus Align- Iris Registration ensures delivery of tx to proper corneal site, well centered in spite of hippus –3-d eye tracking x,y,z (limit 1.5mm) –Virtual Reticle (grid overlay) Deliver- Variable Spot scanning with Variable repetition ratehttp :// Deliver- Variable Spot scanning with Variable repetition ratehttp ://

What to do with astigmatism? Have to reduce the surface curvature more in the steep meridian compared to the flat one. Have to reduce the surface curvature more in the steep meridian compared to the flat one. –Slit beam –Elliptical ablation zone –Scanning beam –Ablatable mask

Myopic astigmatic corrections are achieved by applying the laser energy in an elliptical pattern along the central part of the flat meridian, hereby flattening the steep axis Hyperopic astigmatic correction is achieved by applying the laser energy preferentially in the periphery, steepening the flat axis

Slit beam Widens for successive applications Widens for successive applications Uniform deep ablation is produced in the long axis of the slit Uniform deep ablation is produced in the long axis of the slit The surface curvature is reduced only in the meridian where the slit widens The surface curvature is reduced only in the meridian where the slit widens

Ablatable mask A plate of PMMA placed in the path of the laser beam to shield the cornea A plate of PMMA placed in the path of the laser beam to shield the cornea Thinner areas of the mask are ablated first and thus allow deeper ablation of the corresponding area of the cornea Thinner areas of the mask are ablated first and thus allow deeper ablation of the corresponding area of the cornea Also used to treat hyperopia Also used to treat hyperopia

Post op irregular astigmatism Usually because corneal thickness is insufficient Usually because corneal thickness is insufficient Less than 400 microns pre-op is trouble Less than 400 microns pre-op is trouble 250 microns in bed may be insufficient 250 microns in bed may be insufficient Problems seem to occur with thicker than expected flaps- intraoperative pachymetry, post op can do Visante OCT Problems seem to occur with thicker than expected flaps- intraoperative pachymetry, post op can do Visante OCT

Outline Surface Surface –Cornea –Excimer laser PRK PRK Lasik Lasik Lasek Lasek PTK PTK –Incisional AK AK PK (DLK etc) PK (DLK etc) RK RK –Other CK CK Intacs Intacs Invasive Invasive –Lens Clear lens extraction Single vision Multifocal Accommodating Phakic –Silicone Oil

RK Irreversibly flattens the central corneal curvature to reduce Rx Irreversibly flattens the central corneal curvature to reduce Rx 80-90% depth incisions are make in the mid peripheral and peripheral cornea Weakens the cornea, IOP can cause wound gape The mid and peripheral cornea begins to bulge Adult cornea does not stretch and so the conformational change causes a flattening of the central cornea.

RK Greater effect: longer or deeper incisions, more incisions, or a smaller central zone. Diameter of center 3-5mm to avoid glare The more central the incisions, the less the effect. Usually use only 4 or 8 incisions Best for less than -5D 6 months to stabilize

RK

RK Consecutive hyperopia Consecutive hyperopia –Hyperopic shift continues as cornea loses integrity. –May be difficult or impossible to fit with a lens –May need transplant or running sutures to maintain integrity

Astigmatic (arcuate) Keratotomy Surgical correction of astigmatism Surgical correction of astigmatism –Cosmetic –Post IOL –Post PK, trauma, etc. –Results somewhat unpredictable. –Hope for CL that fits or spectacles

AK Place 1-2 deep curved incisions perpendicular to the steep meridian Place 1-2 deep curved incisions perpendicular to the steep meridian Flatten the steep meridia is matched by a steepening 90 degrees away (coupling effect) Flatten the steep meridia is matched by a steepening 90 degrees away (coupling effect) –Coupling ratio flattening/steepening –SE is about the same ratio about 1 Effect is immediate Effect is immediate Subsequent healing affects outcome Subsequent healing affects outcome Wilkins, nomograms innacurate for PK

Astigmatic keratotomy all sutures should be removed because they can be the cause of the astigmatism. all sutures should be removed because they can be the cause of the astigmatism. Keratoplasty wound should be inspected for focal abnormalities. Wound dehiscence and graft override cause flattening of the central cornea in that meridian and may be best corrected by opening and resuturing the wound, despite the lengthy recovery. Keratoplasty wound should be inspected for focal abnormalities. Wound dehiscence and graft override cause flattening of the central cornea in that meridian and may be best corrected by opening and resuturing the wound, despite the lengthy recovery.

Astigmatic keratotomy Arcuate incisions flatten the steeper meridian the same amount as they steepen the flatter meridian; therefore, the net effect is no change in the spherical equivalent. Arcuate incisions greater than 90° are not recommended because of the risk of late wound dehiscence. Arcuate incisions flatten the steeper meridian the same amount as they steepen the flatter meridian; therefore, the net effect is no change in the spherical equivalent. Arcuate incisions greater than 90° are not recommended because of the risk of late wound dehiscence.

Controlling astigmatism in cataract surgery Place incision in steepest meridian of the cornea to reduce cyl Place incision in steepest meridian of the cornea to reduce cyl –May be able to use spherical IOL and get good outcome –Ex: x090 –K 1D residual cyl –Place incision at 180

Relaxing incisions An incision causes the cornea to bulge at that site (weakens the structure) An incision causes the cornea to bulge at that site (weakens the structure) This reduces the surface curvature of the central cornea in the meridian in which the incision is made and induces increased curvature in meridian 90 degrees away This reduces the surface curvature of the central cornea in the meridian in which the incision is made and induces increased curvature in meridian 90 degrees away

Reducing PK cyl/ scarring cyl Incising over 60 degrees over the steep meridian Incising over 60 degrees over the steep meridian If incisions within the graft (not at junction) effect is more predictable and preserves wound healing If incisions within the graft (not at junction) effect is more predictable and preserves wound healing Arcuate is preferred (uniform thickness) Arcuate is preferred (uniform thickness) Longer and more axial have greater effect Longer and more axial have greater effect

Wedge resections >10D cyl >10D cyl Remove deep arcuate wedge measuring degrees from the graft/host junction in the FLAT meridian Remove deep arcuate wedge measuring degrees from the graft/host junction in the FLAT meridian –Opposite of relaxing incision –Wound sutured to shorten the cornea and steepen the curvature in that meridian –The overall effect of wedge resection is to steepen the flat meridian approximately twice as much as it flattens the steeper meridian. The net effect is an increase in myopia or a decrease in hyperopia. The surgical technique involves removing a wedge of tissue along the flat meridian of the cornea.

Compression sutures Tight suture in the flat meridian will increases the curvature of the cornea adjacent to it and displace the apex away from it Tight suture in the flat meridian will increases the curvature of the cornea adjacent to it and displace the apex away from it –Causes the apex of the cornea to bulge away –Note the topography will change if suture dissolves or breaks –Compression sutures used simultaneously with astigmatic keratectomy can markedly increase the effect of the incisions. Compression sutures are placed 90° from the incisions. Suture depth should be approximately 80% of the corneal thickness. The sutures are tied with a slipknot, and tension is adjusted under intraoperative keratometric or keratoscopic control until an overcorrection of 25-50% is achieved.

Outline Surface Surface –Cornea –Excimer laser PRK PRK Lasik Lasik Lasek Lasek PTK PTK –Incisional AK AK PK (DLK etc) PK (DLK etc) RK RK –Other CK CK Intacs Intacs Invasive Invasive –Lens Clear lens extraction Single vision Multifocal Accommodating Phakic –Silicone Oil

Conductive Keratoplasty Increases the asphericity of the cornea Increases the asphericity of the cornea Initially conceived as an alternative to hyperopic excimer procedures. Initially conceived as an alternative to hyperopic excimer procedures. MV trial with progressive CL useful. MV trial with progressive CL useful. Some glare Some glare Leave room to move Leave room to move Set up expectations Set up expectations Nobody really sure how it works Nobody really sure how it works

Post operative Still have to use reading or driving glasses Still have to use reading or driving glasses Glare/ monocular diplopia- usually resolves Glare/ monocular diplopia- usually resolves Somewhat difficult to fit with lenses- Somewhat difficult to fit with lenses- Steep bc with aspheric surfaces Steep bc with aspheric surfaces Useful post CE or Lasik Useful post CE or Lasik

Intacs Up to -3D myopia (normals) Sufficient thickness (minimum 450 microns) Removable/ adjustable Think about Intacs then Lasik for High myopes with thinner corneas

Intacs for Ectasia Where to put the segment Where to put the segment One versus two segments One versus two segments May not produce great VA, but allow for CL use or prevent PK May not produce great VA, but allow for CL use or prevent PK May be CL intolerant May be CL intolerant

PK

PK High amounts of irregular cylinder High amounts of irregular cylinder –19% have 5D or more May need subsequent AK May need subsequent AK Up to 50% still need RGP design Up to 50% still need RGP design Expectations Expectations Lamellar techniques promising Lamellar techniques promising Relaxing incisions and/or compression sutures, wedge resection, LK, excimer procedures Relaxing incisions and/or compression sutures, wedge resection, LK, excimer procedures

Suture Removal (lacs) Basis is the same as for PK Basis is the same as for PK

Outline Surface Surface –Cornea –Excimer laser PRK PRK Lasik Lasik Lasek Lasek PTK PTK –Incisional AK AK PK (DLK etc) PK (DLK etc) RK RK –Other CK CK Intacs Intacs Invasive Invasive –Lens Clear lens extraction Single vision Multifocal Accommodating Phakic –Silicone Oil

The lens Change the power Change the power Change the position Change the position Increasingly, to manage presbyopia Increasingly, to manage presbyopia

IOL Calculations Various formulas Various formulas –Regression (SRK, SRKII) –Theoretical (Hoffer, Haigis, Holladay) based on reduced eye models based on reduced eye models –One refractive surface for the cornea and thin lens for IOL

IOL calculations SRK SRK IOL Power – A (IOL specific) -0.9 x K(mean) – 2.5 x AL IOL Power – A (IOL specific) -0.9 x K(mean) – 2.5 x AL SRK II- A constant varies w/ axial length SRK II- A constant varies w/ axial length

Theoritical basis Power-[n/(AL-d)]-(n/[n/(K+TR)]-d]) Power-[n/(AL-d)]-(n/[n/(K+TR)]-d]) –d is effective lens position –TR = target Rx at corneal plane

What’s the difference between various theoretical formulas? Estimated position of the IOL and the effective refractive index to transform corneal radius to power Estimated position of the IOL and the effective refractive index to transform corneal radius to power In the US (holladay, SRK/T etc) use the AL and K for prediction of IOL position In the US (holladay, SRK/T etc) use the AL and K for prediction of IOL position

Post Refractive SX calculations K’s and topography tend to overestimate corneal refractive power after RS K’s and topography tend to overestimate corneal refractive power after RS This will cause underestimation of the IOL power leading to a hyperopic outcome This will cause underestimation of the IOL power leading to a hyperopic outcome

Solutions post Refractive SX Clinical History Method Clinical History Method Subtract SE change induced by the sx form the K (diopters) measured before the refractive surgery then use formula Subtract SE change induced by the sx form the K (diopters) measured before the refractive surgery then use formula Make sure it the Rx after stabilization and not a phakic myopic shift. Make sure it the Rx after stabilization and not a phakic myopic shift.

Solutions post RS for IOL’s Hard contact lens method Hard contact lens method Determines difference between MR both with and w/o a regp of known bc and subtracts this difference from the BC Determines difference between MR both with and w/o a regp of known bc and subtracts this difference from the BC –Refract and calculate SE at spectacle plane –Place pl rgp of some known bc and perform spherical refraction –IF SE the same, cornea has same power as bc of the lens –Hyperopic shift= power is greater than bc –Myopic shift= power is smaller than bc –Calculation of postop mean K: bc of cl + change in Rx

Solutions for post RS IOL’s Look at difference between anterior and posterior lens surface Look at difference between anterior and posterior lens surface Pre sx, they should be the same. Pre sx, they should be the same. Post RX, the posterior should mimic what the pre-op K’s are Post RX, the posterior should mimic what the pre-op K’s are –Newer topography devices have this capability

Solutions for post RS iol’s Calculate with std formula using pre-op biometry data Calculate with std formula using pre-op biometry data Enter initial ametropia as target refraction Enter initial ametropia as target refraction

Solutions for post RS IOL’s Empirical correction Empirical correction We know that the true corneal power can be predicted from the measured power We know that the true corneal power can be predicted from the measured power –The effect of overestimation of corneal power is linear with respect to the amount of correction d/t refractive surgery. - Zeiss instrument : 24% has to be subtracted from measured K’s to get true K’s

Calculation of toric IOLs Ok to use conventional formulas if all axes of all toric surfaces are aligned. Ok to use conventional formulas if all axes of all toric surfaces are aligned. Just calculate each meridian separately If use formula that bases lens position is based on K, you will get two different predicted positions Cylinder of toric lens must be aligned with axis corneal astigmatism

Toric IOL’s Spherical front and toric back surfaces Spherical front and toric back surfaces –May cause meridional magnification issues –Bitoric IOL normalizes meridional differences –Ray tracing schemes

Post Intacs IOL Calculations Who knows? Who knows?

Pediatric IOL Calculations None work well None work well Issues with emmetropization Issues with emmetropization PCO PCO Current formulas based on adult eyes Current formulas based on adult eyes

Monovision IOL Calculations Try to aim for and set up expectations Try to aim for and set up expectations Same for any surgical monovision Same for any surgical monovision Can try MF IOL plus modified MV Can try MF IOL plus modified MV

ReStor IOL Diffraction based system, sort of like simultaneous bifocal soft contact lenses Diffraction based system, sort of like simultaneous bifocal soft contact lenses Again, expectations Again, expectations

Array IOL

Accommodating IOL Work on the focus shift principle Accommodative effort by CM exerts Pressure on vitreous Increases pressure in vitreous which Causes anterior displacement of IOL Brings focus in front of retina, functional pseudoaccommodation 1mm forward shift = 1.6D accom

Pseudoaccommodation Pseudoaccommodation –Increased depth of focus –Spherical aberration

Crystalens Silicone Silicone Plate haptics ensure posterior position in capsular bag Plate haptics ensure posterior position in capsular bag Hinged haptic facilitates maximal forward movement Hinged haptic facilitates maximal forward movement

Phakic IOLs

Phakic IOL

Silicone Oil- effects Silicone Oil has higher n than lens and changes the posterior lens from a converging to a diverging interface. Silicone Oil has higher n than lens and changes the posterior lens from a converging to a diverging interface. –Induces hyperopic shift from 5-7D –In an aphakic eye, the curved anterior surface and higher refractive index of silicon oil compared to the lens will cause a myopic shift, causing more limited hyperopic Rx (+6 or so)

Scleral Buckles Induce myopia Induce myopia Induce Cyl Induce Cyl

Gas Phakic eye will increase the refractive power of the posterior lens surface and cause a large myopic shift Phakic eye will increase the refractive power of the posterior lens surface and cause a large myopic shift –May be able to do indirect w/o a lens! –Aphakic eye will makes posterior cornea highly diverging and almost neutralizes the power of the cornea