CHEE 4401 TABLETS u tablet ä a mixture of powders compacted to form a single, rigid body u advantages

CHEE 4402 Types u intended for release into GIT ä compressed tablets ä multiple compressed tablets u effervescents u chewable u buccal or sublingual u vaginal u coated tablets ä sugar, polymer film, gelatin, enteric u extended release u immediate release

CHEE 4403 Desired Properties u contains stated amount of drug u able to withstand stresses of manufacture, transport and handling u provides desired bioavailability u acceptable to patient

CHEE 4404 Drug Release

CHEE 4405 Tabletting Process u Basics ä powders fed into a die ä powder compressed between punches ä tablet ejected from die

CHEE 4406 Tabletting u Powder Properties ä free flowing particles ä cohesion of particles upon compaction ä compacted particles must not adhere to punches and die u 3 tabletting methods ä wet granulation ä dry granulation ä direct compression

CHEE 4407 Wet Granulation

CHEE 4408 Dry Granulation

CHEE 4409 Direct Compression

CHEE Machinery rotary tablet press

CHEE Tablet Components u drug u fillers u binders u disintegrants u antifrictional agents ä antiadherents, glidants, lubricants u miscellaneous