Novel Technologies to assess Gut Health Claims for Carbohydrates subtheme: Immunobarrier Paul de Vos (UMCG)

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Presentation transcript:

Novel Technologies to assess Gut Health Claims for Carbohydrates subtheme: Immunobarrier Paul de Vos (UMCG)

Carbohydrates Design a technology platform: Design a technology platform: to assess health benefits that meet EFSA requirement

Immunemodulatory Food components Stimulating specific immunity/memory Food enhanced stimulation of epithelial barrier Delivery and uptake of fragile vitamines, carbohydrates, fibers etc Design a technology platform: Design a technology platform: to assess health benefits that meet EFSA requirement

1. HTP screening to identify immunemodulating carbohydrates and get insight in stage/mechanism of effect. Design a technology platform: Design a technology platform: to assess health benefits that meet EFSA requirement 2. Testing in appropriate animal model (eg vaccination, allergy, Th1 and Th2 etc) Successful compounds will enter subtheme human studies (healthy/adults/infants) Identification of specific effect: (i) Immune stimulation/suppressing/regulatory (ii) Beneficial for adults, infants, diseased or healthy subjects, male or female

1. HTP screening to identify immunemodulating carbohydrates and get insight in stage/mechanism of effect. Design a technology platform: Design a technology platform: to assess health benefits that meet EFSA requirement 2. Testing in appropriate animal model Based on results of 1. in depth analysis on mechanisms in experimental animal studies Assays to measure effect on mucus production/function, Assays to measure effect on gut epithelium (permeability, defensins etc) Assays to measure effect on lymphocytes/dendritics Assays to identify effects on pattern recognition receptors  Combined leads to insight how and where carbohydrates work Vaccination, Pseudomonas, RSV, Rota, influenza, Listeria monoc., Trichinella Spiralis infection models, Allergy models (cow’s milk, henns egg, peanut allergy), DTH models, autoimmune diabetes models, asthma models, COPD models, cachexia models, inflammation models, arthritis (OA)/RA models

Design a technology platform: Design a technology platform: to assess health benefits that meet EFSA requirement H. Wichers H. Schmidt H. Savelkoul J. Dekker J. Mes H. Schols J. Garssen P. de Vos M.M. Faas H.J. Verkade M. Priebe (expertise: HTP systems, animals models) Other contributing institutes/companies and participants welcome !