Multipurpose Prevention Technologies What are they & why do we need them? [Presenter name, degree, affiliation] [Event title] [Date]

Multipurpose Prevention Technologies for Reproductive Health What do women want and need?

Every year...  80 million unintended pregnancies  358,000 women die from pregnancy- related complications  2.5 million people infected with HIV  340 million new gonorrhea, syphilis, trichomonas infections  250,000 deaths from cervical cancer  16 % (15-49) have genital herpes (HSV-2)

products that…  Prevent pregnancy, HIV/AIDS & STIs at the same time  Ensure women’s privacy and safety  Are affordable & easily available  Are designed by women for their specific needs & preferences Imagine

Multipurpose Prevention Technologies

The Challenge

50 years of contraceptive advances Sheldon Segal First long term drug delivery device Norplant

;Female-controlled MPTs Female CondomSILCS DiaphragmWomen’s Condom

Currently available MPTs Female CondomMale Condom

Emerging MPTs Drug combinations Multipurpose vaccines Drug/device combinations Bacterial therapeutics Nanoparticals

Potential Delivery Mechanisms for MPTs  Devices  SILCS Diaphragm  Women’s Condom  Vaginal Rings  Drug release rates differ by ring type  Matrix rings vs. Reservoir rings  Release rates differ in-vitro from in-vivo  Vaginal Tablet  Combining different class ART  Vaginal Film  Nontoxic to cells and flora, fast dissolution

Multipurpose Vaccines: the future  Today: Single purpose vaccines (HPV & HBV) are commercially available  Next 2 decades: Dual-purpose vaccines that prevent transmission of HSV, HIV, Gonorrhea, Chlamydia, Trichomonas or other STIs  Contraceptive vaccines not likely

Collaboration, advocacy, & research to advance MPTs

Initiative on MPTs: Partner Organizations

MPTs in the Pipeline Mapping Matrix:

CAMI Activities  MPT Think Tank (May 2011)  Target Product Profile working groups (May – Oct 2011)  ARHP Conference (September 2011)  APHA Conference (October 2011)  International MPT Symposium, DC (November 2011)  International MPT Symposium, London (January 2012)  Microbicides 2012 Conference, Sydney (April 2012)  NEXT STEPS

Future directions and priorities  Support and coordinate novel approaches for multi- disciplinary collaboration  Facilitate funding for research & development  Expand global and US support  Refine priority Product Profiles  Assist with clarifying the regulatory pathways

Questions?