VALVULAR HEART Diseases Prof. Mohammed Arafah MB,BS FACP FRCPC FACC.

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Presentation transcript:

VALVULAR HEART Diseases Prof. Mohammed Arafah MB,BS FACP FRCPC FACC

ALL cardiac valves can be involved in pathological processes

Etiology Congenital : Congenital : - Bicuspid or unicuspid. - Bicuspid or unicuspid. - Subvalvular or supravalvular. - Subvalvular or supravalvular. Acquired : Acquired : - Rheumatic. - Rheumatic. - Degeneration. - Degeneration. - myxomatous - myxomatous - calcification - calcification - Ischaemic. - Ischaemic. - Infective Endocarditis. - Infective Endocarditis. - Valve ring dilatation. - Valve ring dilatation.

TYPES of Presentations Acute Presentation : Acute Presentation : - acute mitral regurgitation due to - acute mitral regurgitation due to eg acute myocardial infarction eg acute myocardial infarction acute chordea tendineae rupture acute chordea tendineae rupture

TYPES of Presentations Chronic Presentation : Chronic Presentation : - chronic mitral regurgitation due to - chronic mitral regurgitation due to eg RHRUMATIC fever. eg RHRUMATIC fever. Mitral valve Prolapse. Mitral valve Prolapse. - chronic aortic regurgitation due to - chronic aortic regurgitation due to eg Bicuspid Aortic valve. eg Bicuspid Aortic valve.

HEAMODYNAMICS Consequences Pressure Overload : Pressure Overload : - Aortic stenosis - Aortic stenosis Left Ventricular hypertrophy Left Ventricular hypertrophy - Mitral stenosis - Mitral stenosis Left Atriarl hypertrophy & dilatation Left Atriarl hypertrophy & dilatation

HEAMODYNAMICS Consequences Volume Overload : Volume Overload : - chronic mitral regurgitation - chronic mitral regurgitation dilated left ventricle & left atria dilated left ventricle & left atria - chronic tricuspid regurgitation - chronic tricuspid regurgitation dilated right ventricle & right atria dilated right ventricle & right atria

SYMPTOMS Dyspnea, paroxysmal nocturnal dyspnea Dyspnea, paroxysmal nocturnal dyspnea orthopnea. orthopnea. Palpitation. Palpitation. Chest pain. Chest pain. Dizziness, prefainting,syncope. Dizziness, prefainting,syncope. Oedema, Ascites Oedema, Ascites Cough. Cough. Fatigue Fatigue Hemoptysis Hemoptysis Symptoms of thromboembolic complication. Symptoms of thromboembolic complication.

SINGS of VALVULAR Diseases Abnormal look ( mitral facies ). Abnormal look ( mitral facies ). Abnormal pulse ( Atrial fibrillation ). Abnormal pulse ( Atrial fibrillation ). Apex beat abnormality. Apex beat abnormality. Sternal or parasternal heave. Sternal or parasternal heave. Thrill. Thrill. Abnormal heart sound. Abnormal heart sound. MURMURS. MURMURS. Systolic or Diastolic. Systolic or Diastolic.

INVESTIGATION ECG. ECG. CXR. CXR. Echo cardiology. Echo cardiology. M mode, 2D,3D. 4 D. TEE. M mode, 2D,3D. 4 D. TEE. Doppler. Doppler. 24 hours monitor for heart rhythm. 24 hours monitor for heart rhythm. MRI. MRI. Cardiac catheterization. Cardiac catheterization.

MITRAL STENOSIS

Rheumatic Fever which is related to streptococcus infections, causing damage to the mitral valve and leading to mitral stenosis later in life. ETIOLOGY

OTHER LESS COMMON CAUSES OF MITRAL STENOSIS Congenital Mitral Stenosis Systemic Lupus Erythematosus Rheumatoid Arthritis Atrial Myxoma Malignant Carcinoid Bacterial Endocarditis

MITRAL STENOSIS results in several changes to the integrity of the valves: CUSPS THICKEN COMMISSURES FUSED TOGETHER CHORDAE TENDINAE BECOMES THICKENED & SHORTENED CALCIUM DEPOSITS FORM

PATHOPHYSIOLOGY  In normal adults the mitral valve orifice is 4-6cm².  When the orifice is reduced to approximately 2cm², which is considered mild mitral stenosis, blood can flow from the left atrium to the left ventricle only if propelled by an abnormal pressure gradient – the hemodynamic hallmark of Mitral Stenosis.  When the mitral valve opening is reduced to 1 cm², which is considered critical mitral stenosis, a left atrioventricular pressure gradient of approximately 20mmHg is required to maintain normal cardiac output at rest.

HEAMODYNAMICS Consequences of Mitral stenosis

SIGNS & SYMPTOMS Symptoms of mitral stenosis usually begin with the hallmark signs of DYSPNEA ON EXERTION! The first bouts of dyspnea in patients with mitral stenosis are usually precipitated by exercise, emotional stress, infection, or atrial fibrillation, all of which increase the rate of blood flow across the mitral orifice & result in further elevation of Left

OTHER PRINCIPAL SIGNS AND SYMPTOMS INCLUDES: FatigueOrthopnea Paroxysmal nocturnal dyspnea Pulmonary edema – develops when there’s a sudden ↑ in flow rate across a markedly narrowed mitral orifice. Palpitations – owing to presence of arrhythmias Hemoptysis – due to rupture of thin dilated bronchial veins. Peripheral edema.

DIAGNOSTIC EVALUATIONS Clinical evaluation of Mitral Stenosis begins with an in-depth history and physical exam. Clinical evaluation of Mitral Stenosis begins with an in-depth history and physical exam. ON PHYSICAL EXAMINATION a. a loud S1 – due to abrupt leaflet closure b. a loud S2 – due to ↑ PAP; an opening snap due to tension on valve leaflet c. Diastolic rumble – due to turbulent blood flow across the stenotic valve.

The Diagnostic testing used to evaluate the presence & severity of Mitral Stenosis includes : ECG Chest Radiograph 2D Echocardiogram Doppler Study TransEsophageal Echocardiography

LEFT PARASTERNAL, LONG AXIS VIEW STENOTIC MITRAL VALVE

MVA–2D ECHO = 0.9cm²

COMPLICATIONS OF MITRAL STENOSIS ATRIAL FIBRILLATION LUNG CONGESTION BLOOD CLOTS with SYSTEMIC EMBOLIZATION PULMOARY HYPERTENSION CONGESTIVE HEART FAILURE

MEDICAL MANAGEMENT DIURETICSDIGITALIS ANTI-ARRYHTHMICS ANTI-ARRYHTHMICS ANTICOAGULANTS ANTICOAGULANTSANTIBIOTICS

Intervention PERCUTANEOUS TRANSVENOUS MITRAL COMMISSUROTOMY (PTMC) PERCUTANEOUS TRANSVENOUS MITRAL COMMISSUROTOMY (PTMC) SURGICAL COMMISSUROTOMY SURGICAL COMMISSUROTOMY MITRAL VALVE Replacement. MITRAL VALVE Replacement.

MVA =.982 cm² PRE-PROCEDURE MVA = 1.84 cm² POST-PROCEDURE

MV MEAN GRADIENT=17mmHg MV MEAN GRADIENT =2mmHg PRE-INFLATION POST-INFLATION

MITRAL REGURGITATION

ETIOLOGY RHEUMATIC HEART disease. RHEUMATIC HEART disease. MITRAL Valve Prolapse. MITRAL Valve Prolapse. Others Others - IHD - IHD - Cardiomyopathy ( dilated, hypertrophic ) - Cardiomyopathy ( dilated, hypertrophic ) - Hypertensive heart disease - Hypertensive heart disease - infective endocarditis - infective endocarditis - Myocarditis - Myocarditis - connective tissue disorders - (SLE) - connective tissue disorders - (SLE) - collagen abnormalities - Marfan's syndrome - collagen abnormalities - Marfan's syndrome

SIGNS Laterally displaced (forceful) diffuse apex beat and a systolic thrill. Laterally displaced (forceful) diffuse apex beat and a systolic thrill. Soft first heart sound. Soft first heart sound. Pansystolic murmur. Pansystolic murmur. Prominent third heart sound. Prominent third heart sound.

Real time 4D color full volume imaging Real time 4D color full volume imaging Real time 4D, parasternal long axis, full volume imaging Real time 4D, parasternal long axis, full volume imaging

Management of mitral regurgitation Evidence of progressive cardiac enlargement generally warrants early surgical intervention by either mitral valve repair or replacement. Evidence of progressive cardiac enlargement generally warrants early surgical intervention by either mitral valve repair or replacement. Treatment with ACE inhibitors, diuretics and possibly anticoagulants. Treatment with ACE inhibitors, diuretics and possibly anticoagulants.

Mitral Valve Prolapse

Pathology Large mitral valve leaflets, an enlarged mitral annulus, abnormally long chordae or disordered papillary muscle contraction. Large mitral valve leaflets, an enlarged mitral annulus, abnormally long chordae or disordered papillary muscle contraction. Demonstrate myxomatous degeneration of the mitral valve leaflets. Demonstrate myxomatous degeneration of the mitral valve leaflets. Associated with Marfan's syndrome, thyrotoxicosis, rheumatic or ischaemic heart disease. Associated with Marfan's syndrome, thyrotoxicosis, rheumatic or ischaemic heart disease.

Symptoms Atypical chest pain is the most common symptom. Atypical chest pain is the most common symptom. Palpitations may be experienced because of the abnormal ventricular contraction or because of the atrial and ventricular arrhythmias. Palpitations may be experienced because of the abnormal ventricular contraction or because of the atrial and ventricular arrhythmias. Sudden cardiac death due to fatal ventricular arrhythmias is a very rare but recognized complication. Sudden cardiac death due to fatal ventricular arrhythmias is a very rare but recognized complication.

SIGNS The most common sign is a mid-systolic click. The most common sign is a mid-systolic click. Produced by the sudden prolapse of the valve and the tensing of the chordae tendineae that occurs during systole. Produced by the sudden prolapse of the valve and the tensing of the chordae tendineae that occurs during systole. A late systolic murmur owing to some regurgitation A late systolic murmur owing to some regurgitation

Treatment Beta-blockade is effective for the treatment of the atypical chest pain and palpitations. Beta-blockade is effective for the treatment of the atypical chest pain and palpitations. Mitral valve prolapse associated with significant mitral regurgitation and atrial fibrillation, anticoagulation is advised to prevent thromboembolism. Mitral valve prolapse associated with significant mitral regurgitation and atrial fibrillation, anticoagulation is advised to prevent thromboembolism. Mitral valve prolapse associated with severe mitral regurgitation has a risk of sudden cardiac death. Mitral valve prolapse associated with severe mitral regurgitation has a risk of sudden cardiac death.

AORTIC STENOSIS

Treatment In patients with aortic stenosis, symptoms are a good index of severity and all symptomatic patients should have aortic valve replacement. In patients with aortic stenosis, symptoms are a good index of severity and all symptomatic patients should have aortic valve replacement. Asymptomatic patients should be under regular review for assessment of symptoms and echocardiography. Asymptomatic patients should be under regular review for assessment of symptoms and echocardiography.

AORTIC REGURGITATION

Acute aortic regurgitation Acute rheumatic fever Acute rheumatic fever Infective endocarditis Infective endocarditis Dissection of the aorta Dissection of the aorta Ruptured sinus of Valsalva aneurysm Ruptured sinus of Valsalva aneurysm Failure of prosthetic heart valve Failure of prosthetic heart valve

Chronic aortic regurgitation Rheumatic heart disease Rheumatic heart disease Syphilis Arthritides: Syphilis Arthritides: Reiter's syndrome Reiter's syndrome Ankylosing spondylitis Ankylosing spondylitis Rheumatoid arthritis Rheumatoid arthritis Hypertension (severe) Hypertension (severe) Bicuspid aortic valve Bicuspid aortic valve Aortic endocarditis Aortic endocarditis Marfan's syndrome Marfan's syndrome Osteogenesis imperfecta Osteogenesis imperfecta

Treatment : Aortic valve replacement Because symptoms do not develop until the myocardium fails and because the myocardium does not recover fully after surgery, operation is performed before significant symptoms occur. Because symptoms do not develop until the myocardium fails and because the myocardium does not recover fully after surgery, operation is performed before significant symptoms occur. The timing of the operation is best determined according to haemodynamic, echocardiographic or angiographic criteria The timing of the operation is best determined according to haemodynamic, echocardiographic or angiographic criteria

PULMONIC Valve Diseases PULMONIC Valve stenosis PULMONIC Valve stenosis PULMONIC Valve Rergurgitation PULMONIC Valve Rergurgitation

TRICUSPID Valve Diseases TRICUSPID Valve Regurgitation TRICUSPID Valve Regurgitation TRICUSPID Valve stenosis TRICUSPID Valve stenosis