Cellular Responses

What are the four components of repair? Angiogenesis Migration and proliferation of fibroblasts Deposition of ECM Remodeling

By 3-5 days of tissue repair, what specialized tissue appears? Granulation Tissue

What are the two major factors that induce angiogenesis? bFGF (basic fibroblast growth factor) VEGF (vascular endothelial growth factor)

What are the three phases of cutaneous wound healing? Inflammation Proliferation Maturation

This is the simplest type of cutaneous wound repair; healing of a clean, uninfected surgical incision that is then approximated by surgical sutures Healing by primary intention; primary union

Macrophage

This is the most important fibrogenic agent in cell proliferation TGF-B

What are the factors that influence wound healing? Nutrition Metabolic status Circulatory status Hormones Infection Mechanical factors Foreign bodies Size, location, and type of wound

Excessive formation of collagen that develops following thermal or traumatic injury can give rise to this Hypertrophic Scar

The signaling mechanism by which the cells respond to the signaling molecules that they themselves secrete Autocrine Signaling

This signaling mechanism occurs when one cell type produces the ligand and then acts on adjacent target cells that express the appropriate receptor Paracrine signaling

This signaling mechanism occurs when hormones synthesized by cells of endocrine organs act on target cells distant from their site of synthesis Endocrine signaling

These receptors transmit signals into the cell through trimeric GTP-binding proteins, contain seven transmembrane α-helices, and constitute the largest family of plasma membrane receptors G-Protein Coupled Receptors

This type of growth occurs by enlargement of the lobes of the liver that remain after the operation Compensatory growth or compensatory hyperplasia

This is the most abundant glycoprotein in the basement membrane and it contains binding domains for both ECM and cell surface receptors Laminin

This substance provides resilience and lubrication to connective tissue (notably for the cartilage in joints) and its concentration increases in inflammatory diseases Hyaluronan

These are represented by pale platelet and fibrin deposits alternating with darker red cell-rich layers. It signifies that a thrombus has formed in flowing blood Lines of Zahn

These are thrombi on heart valves resulting from blood-borne bacteria or fungi Vegetations

The consequences are impaired tissue perfusion and cellular hypoxia

This lesion in the maternal pulmonary microvasculature contains squamous cells, lanugo hair, fat from vernix caseosa, and mucin Amniotic Fluid Embolism