CONSTITUTIONAL SYMPTOMS Reassurance Rest/exercise NSAID Antimalarials Steroids (e.g. Prednisone <.25 mg/kg/day) DHEA TCA/SSRI/Behavioral or cognitive therapy.

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Presentation transcript:

CONSTITUTIONAL SYMPTOMS Reassurance Rest/exercise NSAID Antimalarials Steroids (e.g. Prednisone <.25 mg/kg/day) DHEA TCA/SSRI/Behavioral or cognitive therapy

CUTANEOUS Sun avoidance/sunblock Steroids (topical and intralesional) Hydroxychloroquine (plaquenil) Chloroquine (aralen) Quinacrine (atabrine) Dapsone Retinoids (isotretinoin) Clofazamine Azathioprine

ARTICULAR NSAID Antimalarials (HCQ, CQ) Methotrexate Azathioprine Steroids (e.g. Prednisone <.25 mg/kg/day)

HEMATOLOGIC (AIHA/AITP) Steroids (e.g. Prednisone 1 mg/kg/day; Decadron 40 mg day x 4 days) Danazol Dapsone Vincristine Cyclophosphamide Intravenous immunoglobulin (IVIG) Splenectomy CSF (Epogen, Neupogen)

SEROSITIS NSAID (e.g. Indomethacin) Antimalarials (HCQ, CQ) Steroids (e.g. Prednisone <.5 mg/kg/day) Aspiration

VASCULITIS Steroids (e.g. Prednisone 1 mg/kg/day) Cyclophosphamide Plasmapherisis (especially TTP/TMHA) Intravenous immunoglobulin (IVIG)

Current Management of Lupus Glomerulonephritis Steroids oral daily or QOD Pulse solumedrol Cyclophosphamide Azathioprine Cyclosporine Methotrexate Plasmapheresis  synchronized Intravenous gammaglobulin Mycophenolate mofetil 2 chlorodeoxyadenosine Fludarabine Recombinant human DNAse NSAID ACE inhibitors Low protein diet

NERVOUS SYSTEM Steroids (e.g. Prednisone 1 mg/kg/day) Cyclophosphamide IVIG Psychotropics (e.g. Haloperidol) TCA/SSRI