2 High Resolution T2 Imaging Rat versus Mouse T1 MP-RAGE Dark CSF Resolution Rat: 156 x 156 x 700 µ m 3 Mouse: 138 x 117 x 400 µm 3 Coil setup: Transmit:Integrated.

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Presentation transcript:

2 High Resolution T2 Imaging Rat versus Mouse T1 MP-RAGE Dark CSF Resolution Rat: 156 x 156 x 700 µ m 3 Mouse: 138 x 117 x 400 µm 3 Coil setup: Transmit:Integrated body coil Receive:Dedicated brain 2x2 array

3 T2 Imaging Rat brain TSE, magnetization restore TR: 2000 ms TE: 38 ms Tot. scan time: 3 min 10 s FoV: 35 x 35 mm² Slice thickness: 0.8 mm Matrix: 240 x 320 Resolution: 146 x 109 µ m 2 Coil setup: Transmit:Integrated body coil Receive:Rat brain quadrature coil T 2 imaging Bright CSF BGA12S

T2 Map T2 1.2 x x mm3 Traumatic Brain Injury

T2 image of injured Rat spine Spine Injury

Rat Thoracic Spine

Fiber tracking rat spine – T2 background post injury Diffusion Tensor Imaging Fiber tracking mouse brain Pre injury Post injury

Gadolinium-tagged drug in Nasal Passage fMRI segmentation Mouse spine angiography Rat knee

9 Mouse Spine with the MRI CryoProbe ™ Turbo-RARE-T2 TR: 1000 msSlice thickness: 0.5 TE: 12.6 msRes.: 46 x 46 µm² Matrix: 384 x 384NA: 2 Total time 6 min. 24 sec.

10 Specific animal beds: rat, mouse, rabbit Integrated animal warming Stereotactic fixation Animal handling

Cryocoil bed

Mouse Cardiac Coil Rat Body/Cardiac Coil Mouse and Rat Beds Attached to bed

Dr Edward Hall ADC DWI RAT Single Coronal Slice 117um x 238um x 1500um “Qualitative” Analysis - T2 map, T1 map, ADC (DTI)

Rat Body/Cardiac Coil Mouse Body Coil

Cryo-probe images – mouse brain FLASH T2 * weighted TE/TR: 22/350ms Res.: 30x30x500µm Scantime 6min 9.4 T 2Cb 3Cb 5&4Cb 6Cb 7Cb 8Cb 10Cb 9Cb Gray matter: molecular layer White matter Gray matter: granular layer Purkinje cell layer