Modeling and Simulation: Animal health experience PAGE 2013 Glasgow UK Jonathan Mochel, Novartis Advanced Quantitative Sciences

Workshop Animal Health Modeling & Simulation Society 2 | Peers Forum | J. Mochel | AHM&S PAGE 2013 The Animal Health Modeling & Simulation Society (AHM&S) is a newly founded association (2012) that aims at promoting the development, application, and dissemination of modeling and simulation techniques in the field of Veterinary Pharmacology and Toxicology The association is co-chaired by Pr. Johan Gabrielsson (Europe) and Pr. Jim Riviere (USA), and currently consists of core members from both academia and industry Half-a-day workshop with presentation of modeling applications in the animal health field: Methodological challenges with population PK in osteoarthritic dogs Optimizing antimicrobial dosage regimens with mechanistic PK/PD modeling Role of BSA and Hyperthermia on Carboplatin Dosing in Dogs M&S: A Comprehensive Tool To Streamline Drug Development Animal Health Regulatory Science Innovation Initiative (AHRSII)

Main conference AH session: PAGE plenum 3 | Peers Forum | J. Mochel | AHM&S PAGE 2013 Food safety: intersection of pharmacometrics and veterinary medicine (Pr. J Riviere) Presentation of physiological-based pharmacokinetics differences between species Inherent sources of variability for collective therapy (e.g. dose most often unknown) The application of population modeling to the calculation of residual levels and WT Two models for the control of sea lice infections using chemical treatments and biological control on farmed salmon populations (Pr. G Gettinby) Model-based approaches for capturing the infestation level of parasitized fishes Population Model integrates biological stages of the parasite and drug effect (but not T°) From epidemic to elimination: density-vague transmission and the design of mass dog vaccination programs (Pr. D Haydon) High prevalence of rabbies in developing countries (Indonesia)-child death from dog bites Simulation-based comparisons of vaccine strategies for eradicating rabbbies