Genetic analysis Donald Winslow 25 February 2011 Green peas from Donalds garden.

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Presentation transcript:

Genetic analysis Donald Winslow 25 February 2011 Green peas from Donalds garden

Gregor Mendel Illustration from Chapter 3 (Mendelian Genetics) of Klug et al., 2009 Concepts of Genetics, 9 th ed. Pearson/Benjamin Cummings, San Francisco.

Objectives Define: heterozygous, homozygous, recessive, dominant, codominant, incomplete dominance, Punnett square, monohybrid cross, dihybrid cross, phenotype, genotype, P generation, F 1 generation, F 2 generation Explain segregation & independent assortment Use Punnett squares to predict results of monohybrid & dihybrid crosses Including human blood group crosses

Monohybrid cross Illustration from Chapter 3 (Mendelian Genetics) of Klug et al., 2009 Concepts of Genetics, 9 th ed. Pearson/Benjamin Cummings, San Francisco.

Segregation observed Parental (P) Generation: Yellow peas X Green peas First Filial (F 1 ) Generation:Yellow peas Second Filial (F 2 ) Generation:Yellow peas + Green peas

Dihybrid cross Illustration from Chapter 3 (Mendelian Genetics) of Klug et al., 2009 Concepts of Genetics, 9 th ed. Pearson/Benjamin Cummings, San Francisco.

Autosomal & sex-linked genes Autosomes have homologues Sex linkage Sex determination in Drosophila & humans Heterogametic and homogametic sex

Pedigree analysis Male squares, female circles Autosomal recessive disorders Autosomal dominant disorders X-linked recessive disorders PolymorphismPTC tasting

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