The Immune System

Pathogens Defined: microorganisms that cause disease – Viruses: turn cells into virus making factories

Pathogens Defined: microorganisms that cause disease – Viruses: turn cells into virus making factories – Bacteria: prokaryotes that can release toxic chemicals YouTube clip: Good vs. Bad bacteria

Pathogens Defined: microorganisms that cause disease – Viruses: turn cells into virus making factories – Bacteria: prokaryotes that can release toxic chemicals – Fungi: pierce cells and absorb the nutrients

Pathogens Defined: microorganisms that cause disease – Viruses: turn cells into virus making factories – Bacteria: prokaryotes that can release toxic chemicals – Fungi: pierce cells and absorb the nutrients – Protozoans: single cells protista (eukaryotes) Plasmodium causes malaria

Pathogens Defined: microorganisms that cause disease – Viruses: turn cells into virus making factories – Bacteria: prokaryotes that can release toxic chemicals – Fungi: pierce cells and absorb the nutrients – Protozoans: single cells protista (eukaryotes) – Parasites: grow and feed on a host tapeworms

Transmission Some carried by wind, water, direct contact, indirect contact… Vectors: object that carries a pathogen Examples: 1)Malaria – mosquitos carry the protozoan 2)Black Death – carried by flea’s of mice 3)West Nile Virus – carried by birds, but spread by mosquitoes

The Skin 1 st line of defense: physical barrier Oils & sweat destroy some pathogens – Some pathogens burst…some shrivel Skin bacteria bacteria

Mucus Membranes Coat the openings of the body – Nose, mouth, ears, eyes, genitals, anus Lined with cilia & sticky fluids to trap pathogens

White Blood Cells Job: Search & destroy YouTube Clip: Types of White Blood Cells (phagocytes) from the BBC YouTube Clip: Types of White Blood Cells (lymphocytes) from the BBC

White Blood Cells Job: Search & destroy Type 1: Phagocytes – surround & engulf invaders by phagocytosis YouTube Clip: Types of White Blood Cells (phagocytes) from the BBC YouTube Clip: Types of White Blood Cells (lymphocytes) from the BBC

White Blood Cells Job: Search & destroy Type 1: Phagocytes – surround & engulf invaders by phagocytosis Type 2: Lymphocytes – create antibodies & destroy infected body cells YouTube Clip: Types of White Blood Cells (phagocytes) from the BBC YouTube Clip: Types of White Blood Cells (lymphocytes) from the BBC

Blood stream phagocyte bacteria phagocyte

Defense Proteins Antibodies – Created & released by lymphocytes – Attach to antigens (like handcuffs) lymphocyte antibody Y Y Y Y Y Y Y Y

Defense Proteins Antibodies – Created & released by lymphocytes – Attach to antigens (like handcuffs) How do they kill? 1)Causes pathogens to clump 2)Weakens the cell membrane of pathogen

Y Y Y Y Y Y B CELLS MAKE ANTIBODIES ANTIBODIES ATTACH TO ANTIGENS OF THE PATHOGEN PHAGOCYTE DESTROYS PATHOGENS YY Y Y Y ANTIBODIES CAUSE THE PATHOGENS TO CLUMP TOGETHER Blood Stream Y Y Y Y Y YY Y Y Y Y Y phagocyte

Oh no Mr. K. Looks like the killer has us trapped. Dad…I’m scared. What are we gonna do? Sweetie. Don’t be afraid. I told you I would always protect you.

Luke. I want you to take my darling Leia and run to safety. Promise me you will look after her. I promise Mr. K. You’re a good man. Thank you and I want you to know your daughter is in good hands. I know she is. I’m sorry I won’t be there for you in the future. But thank you. Dad. I’m confused. Where are you going? You can’t leave me now.

Looks like it’s just you and me now. You’ll never catch my baby. Argh!!!!!

Interferon 1)Cell becomes infected by virus 2)Infected cell sends interferon to healthy neighbors 3)Interferon causes healthy cell to create defense enzymes 4)Healthy cell able to fight virus Defense Proteins Virus RNA New virus Interferon virus Infected! Interferon New virus Not Infected!

Kobe Kuiz 1)Which part of our immune system coats the openings of the body? 2)How do lymphocytes differ from phagocytes? 3)What are antibodies and how do they help keep us from harm? 4)Which pathogen… absorbs nutrients from living tissue? are prokaryotic? 5)Which illness is spread by mice? 6)What is the vector of malaria?