Designing nanostructured block copolymer surfaces to control protein adhesion by Scott R. Schricker, Manuel L. B. Palacio, and Bharat Bhushan Philosophical Transactions A Volume 370(1967): May 28, 2012 ©2012 by The Royal Society

(a) Structure of the tooth [61] (adapted from and (b) a radiograph showing severe bone loss as a result of periodontal disease (from Rose et al. [82]). Scott R. Schricker et al. Phil. Trans. R. Soc. A 2012;370: ©2012 by The Royal Society

Progression from a scaffold to tissue (adapted from Baum & Mooney [83]). Scott R. Schricker et al. Phil. Trans. R. Soc. A 2012;370: ©2012 by The Royal Society

Synthetic scheme for the diblock copolymers [62]. Scott R. Schricker et al. Phil. Trans. R. Soc. A 2012;370: ©2012 by The Royal Society

Height and phase images of diblock copolymers compared with their respective homopolymers. Scott R. Schricker et al. Phil. Trans. R. Soc. A 2012;370: ©2012 by The Royal Society

Friction mapping of polymer surfaces [62]. Scott R. Schricker et al. Phil. Trans. R. Soc. A 2012;370: ©2012 by The Royal Society

Thermal dependence of the nanostructure. Scott R. Schricker et al. Phil. Trans. R. Soc. A 2012;370: ©2012 by The Royal Society

Height and phase images of the diblock copolymer and respective homopolymers in PBS buffer [62]. Scott R. Schricker et al. Phil. Trans. R. Soc. A 2012;370: ©2012 by The Royal Society

Height and phase images of the diblock and triblock copolymer of MMA and AA in PBS [61]. Scott R. Schricker et al. Phil. Trans. R. Soc. A 2012;370: ©2012 by The Royal Society

Contact angle of diblock and triblock copolymer [61]. Scott R. Schricker et al. Phil. Trans. R. Soc. A 2012;370: ©2012 by The Royal Society

(a) AFM imaging (solid line, height; dashed line, adhesive force) and (b) adhesive force data for BSA adsorption on a PMMA surface [61]. Scott R. Schricker et al. Phil. Trans. R. Soc. A 2012;370: ©2012 by The Royal Society

(a) AFM imaging (solid line, height; dashed line, adhesive force) and (b) adhesive force data for BSA adsorption on the block copolymer surfaces [61]. Scott R. Schricker et al. Phil. Trans. R. Soc. A 2012;370: ©2012 by The Royal Society

Phase image of the block copolymer coated with BSA [61]. Scott R. Schricker et al. Phil. Trans. R. Soc. A 2012;370: ©2012 by The Royal Society

Fibronectin adhesion to PMMA–PAA block copolymer surfaces [107]. Scott R. Schricker et al. Phil. Trans. R. Soc. A 2012;370: ©2012 by The Royal Society

Fibronectin adhesion to PMMA–PHEMA surfaces [107]. Scott R. Schricker et al. Phil. Trans. R. Soc. A 2012;370: ©2012 by The Royal Society

Schematic illustrating the different polymer–protein interaction modes [107]. Scott R. Schricker et al. Phil. Trans. R. Soc. A 2012;370: ©2012 by The Royal Society

Antibody interaction with the RGD group on a polymer surface [111]. Scott R. Schricker et al. Phil. Trans. R. Soc. A 2012;370: ©2012 by The Royal Society

Height and adhesive force maps of the interactions between the antibody-functionalized tip and the PMMA–PAA and PMMA–PHEMA block copolymers with no added protein. Scott R. Schricker et al. Phil. Trans. R. Soc. A 2012;370: ©2012 by The Royal Society

Height and adhesive force maps of the interactions between the antibody-functionalized tip and the PMMA–PAA and PMMA–PHEMA block copolymers with added fibronectin. Scott R. Schricker et al. Phil. Trans. R. Soc. A 2012;370: ©2012 by The Royal Society

Height and adhesive force maps of the interactions between the antibody-functionalized tip and the PMMA–PAA and PMMA–PHEMA block copolymers with added BSA. Data for PMMA and PHEMA are taken from the study of Palacio et al. [111]. Scott R. Schricker et al. Phil. Trans. R. Soc. A 2012;370: ©2012 by The Royal Society

Phase images taken on the polymer surfaces with added fibronectin, along with the corresponding frequency distribution of the measured phase angle variation for the (a) PMMA– PAA series and (b) PMMA–PHEMA series [111]. Scott R. Schricker et al. Phil. Trans. R. Soc. A 2012;370: ©2012 by The Royal Society

XPS survey spectra for the polymer surfaces with fibronectin [119]. Scott R. Schricker et al. Phil. Trans. R. Soc. A 2012;370: ©2012 by The Royal Society

High-resolution C 1s, O 1s, N 1s and S 2s XPS spectra for the polymer surfaces with added fibronectin [119]. Scott R. Schricker et al. Phil. Trans. R. Soc. A 2012;370: ©2012 by The Royal Society

Summary of the major findings on the effect of block copolymer configuration on fibronectin conformation. Scott R. Schricker et al. Phil. Trans. R. Soc. A 2012;370: ©2012 by The Royal Society