Silent Voice Survey A survey of prostate cancer patients in Europe OVERVIEW OF RESULTS

Patient demographics

GfK HealthCare 3 Number of patients and age Total Country FranceGermanyItalySpainPoland Total number of patients Age of patientsTotal Country FranceGermanyItalySpainPoland years0%2%0% years6%8%12%4% years30%34%32%38%22%25% Over 65 years63%54%56%58%74%71% Not stated0%2%0%

GfK HealthCare 4 Healthcare professional most involved in patient treatment and management following diagnosis Total Country Healthcare professionalFranceGermanyItalySpainPoland The Urologist67%86%66%72%40%73% The Oncologist23%8%20%14%48%25% Your GP/Primary Care Physician 4%2%4%8%2% The Radiologist2% 4%0%4%0% The Radiotherapist2%0%2%6%0% None of the above1%0%4%0% Don't know2% 0% 6%0%

GfK HealthCare 5 Treatment course undertaken following diagnosis Total Country Treatment course(s)FranceGermanyItalySpainPoland Surgery47%58%60%44%24%50% Hormone therapy39%26%30%70%30%40% Radiotherapy 37%28%40%36%52%29% Chemotherapy9%6%18%2%18%0% Pharmacological treatment / tablets6%2%4%0%8%13% Monitoring phase / waiting for a treatment decision 1%4%0% 2% Infusions (unspec)1%0%2%0% 2% Injections (unspec)0% 2%0% Don't know1%0%2%0%2%0%

How are prostate cancer patients accessing information about their condition?

GfK HealthCare 7 Did patients receive information about prostate cancer at diagnosis? Base: All respondents (Total=252/France=50/Germany=50/Italy=50/Spain=50/Poland=52) JUNE 2009MAIN SURVEY Q: When you were first diagnosed with prostate cancer were you given any information concerning this condition?

GfK HealthCare 8 How informative was the information patients were given about prostate cancer? Base: All who were given any information concerning prostate cancer when first diagnosed (Total=201/France=33/Germany=34/Italy=43/Spain=45/Poland=46) JUNE 2009MAIN SURVEY Q: On a scale of 1 to 4, please rate the information you were given, upon being initially diagnosed with prostate cancer, for each of the following aspects? - Explanation of your condition

GfK HealthCare 9 How informative was the information patients were given about the likely outcome of their diagnosis? Base: All who were given any information concerning prostate cancer when first diagnosed (Total=201/France=33/Germany=34/Italy=43/Spain=45/Poland=46) JUNE 2009MAIN SURVEY Q: On a scale of 1 to 4, where 1 is 'Not at all informative' and 4 is 'very informative', please rate the information you were given, upon being initially diagnosed with prostate cancer, for each of the following aspects?- Explanation of the likely outcome

GfK HealthCare 10 How informative was the information patients were given about their treatment options? Base: All who were given any information concerning prostate cancer when first diagnosed (Total=201/France=33/Germany=34/Italy=43/Spain=45/Poland=46) JUNE 2009MAIN SURVEY Q: On a scale of 1 to 4, where 1 is 'Not at all informative' and 4 is 'very informative', please rate the information you were given, upon being initially diagnosed with prostate cancer, for each of the following aspects? - Explanation of your treatment options

GfK HealthCare 11 Which information sources did patients find most useful following diagnosis? Base: All respondents (Total=252/France=50/Germany=50/Italy=50/Spain=50/Poland=52) JUNE 2009MAIN SURVEY Q:Following your initial diagnosis of prostate cancer, which ONE of the following sources of information did you find most useful?

What is important to prostate cancer patients when making decisions about their treatment options?

GfK HealthCare 13 How do patients prefer treatment decisions to be made? Base: All respondents (Total=252/France=50/Germany=50/Italy=50/Spain=50/Poland=52) JUNE 2009MAIN SURVEY Q:Which ONE of the following options best describes how you would prefer your doctor to approach treatment decisions with you?

GfK HealthCare 14 How informed do patients feel about their treatment options? Base: All respondents (Total=252/France=50/Germany=50/Italy=50/Spain=50/Poland=52) JUNE 2009MAIN SURVEY Q: With regard to the treatment options you were given, which one of the following options best describes how informed you felt?

GfK HealthCare 15 What other factors are important to patients when making treatment decisions? Base: All respondents (Total=252/France=50/Germany=50/Italy=50/Spain=50/Poland=52) JUNE 2009MAIN SURVEY Importance ranking 1st - 4thSide-effects Impact on your lifestyle Impact on your partner / family Cost of the treatment Ranked first42%40%14%4% Ranked second32%35%28%6% Ranked third25%19%45%11% Ranked forth1%6%13%80% Mean Standard deviation Standard error Q: Aside from the effectiveness of your treatment, please rank, in order of their importance to you, the following factors that you feel your doctor should take into account when making treatment decisions.

GfK HealthCare 16 If impact on lifestyle is important to patients, have they discussed this with their physician? Base: All respondents who ranked 'impact on your lifestyle' as the most important factor in their treatment decision (Total=102/France=8/Germany=30/Italy=28/Spain=16/Poland=20) JUNE 2009MAIN SURVEY Q: Having ranked 'impact on lifestyle' as the most important consideration your physician should take into account (aside from the effectiveness of the treatment), have you discussed this with him/her?

GfK HealthCare 17 Why haven’t some patients discussed impact on lifestyle with their physician? Base: All respondents who ranked 'impact on your lifestyle' as the most important factor in their treatment decision but did not discuss this with their physician (Total=31/France=2/Germany=12/Italy=3/Spain=5/Poland=9) JUNE 2009MAIN SURVEY Q: What has held you back from discussing the potential impact your treatment may have on your lifestyle?

GfK HealthCare 18 What is most important to prostate cancer patients following diagnosis? Base: All respondents (Total=252/France=50/Germany=50/Italy=50/Spain=50/Poland=52) JUNE 2009MAIN SURVEY Importance ranking 1st - 4th Controlling my disease Maintaining as much of a normal lifestyle as possible Minimising the impact of my disease on my family Having as few visits to the doctor for treatment as possible Ranked first65%27%6%2% Ranked second24%53%19%4% Ranked third9%17%59%15% Ranked forth2%3%15%80% Mean Standard deviation Standard error Q: Having been diagnosed with prostate cancer, please rank, in order of their importance to you, the following four options.