How to Use This Presentation • To View the presentation as a slideshow with effects select “View” on the menu bar and click on “Slide Show”, or simply press F5 on the top row of your keyboard. • To advance to the next slide click the left mouse button once. • From the Chapter screen you can click on any section to go directly to that section’s presentation. • Blank or “missing” areas of a slide will remain hidden until the left mouse button is clicked. • You may exit the slide show at any time by pressing the Esc key Header – white 24 points Arial Bold Body text – white 20 points Arial Bold, dark yellow highlights Bullets – dark yellow Copyright – white 12 points Arial Background name: HST-Presentation_blue.jpg, Size: Height: 7.52" Width: 10.02" Scale: 70% Position on slide: Horizontal - 0" Vertical - 0" Copyright © by Holt, Rinehart and Winston. All rights reserved.

Section 1: What Does DNA Look Like? Section 2: How Does DNA Work? Chapter 6 Genes and DNA Section 1: What Does DNA Look Like? Section 2: How Does DNA Work? Header first line (section#) – white 24 points Arial Bold Header second line (title) – white 28 points Arial Bold Title – yellow 28 points Arial Bold Body text – white24 points Arial and Arial Bold Bullets – yellow Copyright – white 12 points Arial Background name: HST-Presentation_blue.jpg, Size: Height: 7.52" Width: 10.02" Scale: 70% Position on slide: Horizontal - 0" Vertical - 0" End of Slide Copyright © by Holt, Rinehart and Winston. All rights reserved.

What Does DNA Look Like? Bellringer Section 1 Can you explain the difference between traits and characteristics? Which is more closely associated with DNA and genes? Do you know where DNA and genes are found in the body? In specific cells? Write your answers in your science journal. Header first line (section#) – white 24 points Arial Bold Header second line (title) – white 28 points Arial Bold Title – yellow 28 points Arial Bold Body text – white24 points Arial and Arial Bold Bullets – yellow Copyright – white 12 points Arial Background name: HST-Presentation_blue.jpg, Size: Height: 7.52" Width: 10.02" Scale: 70% Position on slide: Horizontal - 0" Vertical - 0" Copyright © by Holt, Rinehart and Winston. All rights reserved.

What Does DNA Look Like? Objectives Section 1 List three important events that led to understanding the structure of DNA. Describe the basic structure of a DNA molecule. Explain how DNA molecules can be copied. Header first line (section#) – white 24 points Arial Bold Header second line (title) – white 28 points Arial Bold Title – yellow 28 points Arial Bold Body text – white24 points Arial and Arial Bold Bullets – yellow Copyright – white 12 points Arial Background name: HST-Presentation_blue.jpg, Size: Height: 7.52" Width: 10.02" Scale: 70% Position on slide: Horizontal - 0" Vertical - 0" End of Slide Copyright © by Holt, Rinehart and Winston. All rights reserved.

The Pieces of the Puzzle Section 1 What Does DNA Look Like? The Pieces of the Puzzle Nucleotides: The Subunits of DNA DNA is made of subunits called nucleotides that. A nucleotide consists of a sugar, a phosphate, and a base. Chargaff’s Rule Erwin Chargaff found that the amount of guanine always equals the amount of cytosine. Franklin’s Discovery Chemist Rosalind Franklin was able to make images of DNA molecules. Watson and Crick’s Model James Watson and Francis Crick used Chargaff’s and Franklin’s research to build a model of DNA. Header first line (section#) – white 24 points Arial Bold Header second line (title) – white 28 points Arial Bold Title – yellow 28 points Arial Bold Body text – white24 points Arial and Arial Bold Bullets – yellow Copyright – white 12 points Arial Background name: HST-Presentation_blue.jpg, Size: Height: 7.52" Width: 10.02" Scale: 70% Position on slide: Horizontal - 0" Vertical - 0" End of Slide Copyright © by Holt, Rinehart and Winston. All rights reserved.

DNA’s Double Structure Section 1 What Does DNA Look Like? DNA’s Double Structure The Double Helix The shape of DNA is shown on the next slide. As you can see, a strand of DNA looks like a twisted ladder. Header first line (section#) – white 24 points Arial Bold Header second line (title) – white 28 points Arial Bold Title – yellow 28 points Arial Bold Body text – white24 points Arial and Arial Bold Bullets – yellow Copyright – white 12 points Arial Background name: HST-Presentation_blue.jpg, Size: Height: 7.52" Width: 10.02" Scale: 70% Position on slide: Horizontal - 0" Vertical - 0" End of Slide Copyright © by Holt, Rinehart and Winston. All rights reserved.

Section 1 DNA Structure Header first line (section#) – white 24 points Arial Bold Header second line (title) – white 28 points Arial Bold Title – navy 28 points Arial Bold Body text – black 24 points Arial and Arial Bold Bullets – navy Copyright – white 12 points Arial Background name: HST-Presentation_white.jpg Size: Height: 7.52" Width: 10.02" Scale: 70% Position on slide: Horizontal - 0" Vertical - 0" Copyright © by Holt, Rinehart and Winston. All rights reserved.

What Does DNA Look Like? Making Copies of DNA Section 1 How Copies Are Made During replication, a DNA molecule is split down the middle, where the bases meet. The bases on each side of the molecule are used as a pattern for a new strand. When Copies Are Made DNA is copied every time a cell divides. Header first line (section#) – white 24 points Arial Bold Header second line (title) – white 28 points Arial Bold Title – yellow 28 points Arial Bold Body text – white24 points Arial and Arial Bold Bullets – yellow Copyright – white 12 points Arial Background name: HST-Presentation_blue.jpg, Size: Height: 7.52" Width: 10.02" Scale: 70% Position on slide: Horizontal - 0" Vertical - 0" End of Slide Copyright © by Holt, Rinehart and Winston. All rights reserved.

How DNA Works Bellringer Section 2 Unscramble the following words: tpsoneir neesg Now think of three words you associate with each of the above words and use them all in a paragraph that highlights what you know about DNA. Write your paragraph in your science journal. Header first line (section#) – white 24 points Arial Bold Header second line (title) – white 28 points Arial Bold Title – yellow 28 points Arial Bold Body text – white24 points Arial and Arial Bold Bullets – yellow Copyright – white 12 points Arial Background name: HST-Presentation_blue.jpg, Size: Height: 7.52" Width: 10.02" Scale: 70% Position on slide: Horizontal - 0" Vertical - 0" Copyright © by Holt, Rinehart and Winston. All rights reserved.

How DNA Works Objectives Section 2 Explain the relationship between DNA, genes, and proteins. Outline the basic steps in making a protein. Describe three types of mutations, and provide an example of a gene mutation. Describe two examples of uses of genetic knowledge. Header first line (section#) – white 24 points Arial Bold Header second line (title) – white 28 points Arial Bold Title – yellow 28 points Arial Bold Body text – white24 points Arial and Arial Bold Bullets – yellow Copyright – white 12 points Arial Background name: HST-Presentation_blue.jpg, Size: Height: 7.52" Width: 10.02" Scale: 70% Position on slide: Horizontal - 0" Vertical - 0" End of Slide Copyright © by Holt, Rinehart and Winston. All rights reserved.

How DNA Works Unraveling DNA Section 2 Coiled and Bundled DNA is often wound around proteins, coiled into strands, and then bundled up even more. In a cell that has a nucleus, the strands of DNA and proteins are bundled into chromosomes, as shown on the next slide. Header first line (section#) – white 24 points Arial Bold Header second line (title) – white 28 points Arial Bold Title – yellow 28 points Arial Bold Body text – white24 points Arial and Arial Bold Bullets – yellow Copyright – white 12 points Arial Background name: HST-Presentation_blue.jpg, Size: Height: 7.52" Width: 10.02" Scale: 70% Position on slide: Horizontal - 0" Vertical - 0" End of Slide Copyright © by Holt, Rinehart and Winston. All rights reserved.

Unraveling DNA Section 2 Header first line (section#) – white 24 points Arial Bold Header second line (title) – white 28 points Arial Bold Title – navy 28 points Arial Bold Body text – black 24 points Arial and Arial Bold Bullets – navy Copyright – white 12 points Arial Background name: HST-Presentation_white.jpg Size: Height: 7.52" Width: 10.02" Scale: 70% Position on slide: Horizontal - 0" Vertical - 0" Copyright © by Holt, Rinehart and Winston. All rights reserved.

How DNA Works Genes and Proteins Section 2 Proteins and Traits Proteins help determine how tall you grow, what colors you can see, and whether your hair is curly or straight. Help from RNA Another type of molecule that helps make proteins is called RNA, or ribonucleic acid. RNA is so similar to DNA that RNA can serve as a temporary copy of a DNA sequence. Header first line (section#) – white 24 points Arial Bold Header second line (title) – white 28 points Arial Bold Title – yellow 28 points Arial Bold Body text – white24 points Arial and Arial Bold Bullets – yellow Copyright – white 12 points Arial Background name: HST-Presentation_blue.jpg, Size: Height: 7.52" Width: 10.02" Scale: 70% Position on slide: Horizontal - 0" Vertical - 0" End of Slide Copyright © by Holt, Rinehart and Winston. All rights reserved.

Genes and Proteins, continued Section 2 How DNA Works Genes and Proteins, continued The Making of a Protein The first step in making a protein is to copy one side of the segment of DNA containing a gene. You can see the next steps of protein production on the following two slides. Header first line (section#) – white 24 points Arial Bold Header second line (title) – white 28 points Arial Bold Title – yellow 28 points Arial Bold Body text – white24 points Arial and Arial Bold Bullets – yellow Copyright – white 12 points Arial Background name: HST-Presentation_blue.jpg, Size: Height: 7.52" Width: 10.02" Scale: 70% Position on slide: Horizontal - 0" Vertical - 0" End of Slide Copyright © by Holt, Rinehart and Winston. All rights reserved.

The Making of a Protein: A Section 2 The Making of a Protein: A Header first line (section#) – white 24 points Arial Bold Header second line (title) – white 28 points Arial Bold Title – navy 28 points Arial Bold Body text – black 24 points Arial and Arial Bold Bullets – navy Copyright – white 12 points Arial Background name: HST-Presentation_white.jpg Size: Height: 7.52" Width: 10.02" Scale: 70% Position on slide: Horizontal - 0" Vertical - 0" Copyright © by Holt, Rinehart and Winston. All rights reserved.

The Making of a Protein: B Section 2 The Making of a Protein: B Header first line (section#) – white 24 points Arial Bold Header second line (title) – white 28 points Arial Bold Title – navy 28 points Arial Bold Body text – black 24 points Arial and Arial Bold Bullets – navy Copyright – white 12 points Arial Background name: HST-Presentation_white.jpg Size: Height: 7.52" Width: 10.02" Scale: 70% Position on slide: Horizontal - 0" Vertical - 0" Copyright © by Holt, Rinehart and Winston. All rights reserved.

How DNA Works Changes in Genes Section 2 Mutations Changes in the number, type, or order of bases on a piece of DNA are known as mutations. Do Mutations Matter? There are three possible consequences to changes in DNA: an improved trait, no change, or a harmful trait. How Do Mutations Happen? Mutations happen regularly because of random errors when DNA is copied. Header first line (section#) – white 24 points Arial Bold Header second line (title) – white 28 points Arial Bold Title – yellow 28 points Arial Bold Body text – white24 points Arial and Arial Bold Bullets – yellow Copyright – white 12 points Arial Background name: HST-Presentation_blue.jpg, Size: Height: 7.52" Width: 10.02" Scale: 70% Position on slide: Horizontal - 0" Vertical - 0" End of Slide Copyright © by Holt, Rinehart and Winston. All rights reserved.

An Example of Substitution Section 2 How DNA Works An Example of Substitution Sickle Cell Anemia is a disease that affects red blood cells. It is caused by a substitution that causes a change in a single amino acid in a blood protein. The DNA sequence GAA, when copied as mRNA, gives the instructions to place the amino acid glutamic acid into the growing protein. If the original DNA sequence is changed to GTA, the sequence will code for the amino acid valine instead. Header first line (section#) – white 24 points Arial Bold Header second line (title) – white 28 points Arial Bold Title – yellow 28 points Arial Bold Body text – white24 points Arial and Arial Bold Bullets – yellow Copyright – white 12 points Arial Background name: HST-Presentation_blue.jpg, Size: Height: 7.52" Width: 10.02" Scale: 70% Position on slide: Horizontal - 0" Vertical - 0" End of Slide Copyright © by Holt, Rinehart and Winston. All rights reserved.

An Example of Substitution, continued Section 2 How DNA Works An Example of Substitution, continued When valine is substituted for glutamic acid in a blood protein, the red blood cells are changed into a sickle shape. The genetic origin of sickle cell anemia is shown on the next slide. Header first line (section#) – white 24 points Arial Bold Header second line (title) – white 28 points Arial Bold Title – yellow 28 points Arial Bold Body text – white24 points Arial and Arial Bold Bullets – yellow Copyright – white 12 points Arial Background name: HST-Presentation_blue.jpg, Size: Height: 7.52" Width: 10.02" Scale: 70% Position on slide: Horizontal - 0" Vertical - 0" End of Slide Copyright © by Holt, Rinehart and Winston. All rights reserved.

How Sickle Cell Anemia Results from a Mutation Section 2 How Sickle Cell Anemia Results from a Mutation Header first line (section#) – white 24 points Arial Bold Header second line (title) – white 28 points Arial Bold Title – navy 28 points Arial Bold Body text – black 24 points Arial and Arial Bold Bullets – navy Copyright – white 12 points Arial Background name: HST-Presentation_white.jpg Size: Height: 7.52" Width: 10.02" Scale: 70% Position on slide: Horizontal - 0" Vertical - 0" Copyright © by Holt, Rinehart and Winston. All rights reserved.

Uses of Genetic Knowledge Section 2 How DNA Works Uses of Genetic Knowledge Genetic Engineering Scientists can manipulate individual genes within organisms. This kind of manipulation is called genetic engineering. Genetic Identification Your DNA is unique, so it can be used like a fingerprint to identify you. DNA fingerprinting identifies the unique patterns in an individual’s DNA. Header first line (section#) – white 24 points Arial Bold Header second line (title) – white 28 points Arial Bold Title – yellow 28 points Arial Bold Body text – white24 points Arial and Arial Bold Bullets – yellow Copyright – white 12 points Arial Background name: HST-Presentation_blue.jpg, Size: Height: 7.52" Width: 10.02" Scale: 70% Position on slide: Horizontal - 0" Vertical - 0" End of Slide Copyright © by Holt, Rinehart and Winston. All rights reserved.

The Cell in Action Concept Map Chapter 6 Use the following terms to complete the concept map on the next slide: mutation, amino acids, nucleotide, DNA, adenine, genes, guanine, proteins, chromosomes, cytosine. Header first line (section#) – white 24 points Arial Bold Header second line (title) – white 28 points Arial Bold Title – yellow 28 points Arial Bold Body text – white24 points Arial and Arial Bold Bullets – yellow Copyright – white 12 points Arial Background name: HST-Presentation_blue.jpg, Size: Height: 7.52" Width: 10.02" Scale: 70% Position on slide: Horizontal - 0" Vertical - 0" Copyright © by Holt, Rinehart and Winston. All rights reserved.

Chapter 6 Concept Map Header first line (section#) – white 24 points Arial Bold Header second line (title) – white 28 points Arial Bold Title – navy 28 points Arial Bold Body text – black 24 points Arial and Arial Bold Bullets – navy Copyright – white 12 points Arial Background name: HST-Presentation_white.jpg Size: Height: 7.52" Width: 10.02" Scale: 70% Position on slide: Horizontal - 0" Vertical - 0" Copyright © by Holt, Rinehart and Winston. All rights reserved.

Chapter 6 Concept Map Header first line (section#) – white 24 points Arial Bold Header second line (title) – white 28 points Arial Bold Title – navy 28 points Arial Bold Body text – black 24 points Arial and Arial Bold Bullets – navy Copyright – white 12 points Arial Background name: HST-Presentation_white.jpg Size: Height: 7.52" Width: 10.02" Scale: 70% Position on slide: Horizontal - 0" Vertical - 0" Copyright © by Holt, Rinehart and Winston. All rights reserved.