 Protein Structure Fall 2011 Aaron Zampaglione

Protein Fold Rossmann Fold

Protein Domains (Folds) Four main classes:  All- α  All- β  α + β  α / β  (Membrane and cell surface proteins and peptides)  (Small proteins)

All- α  The lone helix  The helix-turn-helix motif  The four-helix bundle  Helix-helix packing

All- β  β sandwiches and β barrels  Up-and-down antiparallel β sheets  β -propellors  β -trefoils  β -Helix

α+βα+β  Bacterial and mammalian pancreatic ribonucleases  Lysozome  Ubiquitin

α/βα/β  α / β horseshoe  α / β barrels beta-alpha-beta

Motif

Structural Motifs  β - α - β  β -hairpin  Greek Key  Helix-Loop-Helix (HLH)  Helix-Turn-Helix (HTH)  Leucine Zipper  Psi-loop  Zinc Finger

β - α - β Motif

β -hairpin Motif

Greek Key Motif

Helix-Loop-Helix (HLH) Motif

Helix-Turn-Helix (HTH) Motif

Leucine Zipper Motif

Psi-loop Motif

Zinc Finger Motif

Biology Workbench  Protein Tools  Alignment Tools  Structure Tools

Additional Tools  CDART (Motifs)  s s  PROSITE (Motifs)   SCOP (Structure)   CATH (Structure) 

References  Expasy. (1999). Tertiary Protein Structure and folds. Retrieved 08 30, 2011, from Expasy:  Karadaghi, S. (2011). Protein Domains. Retrieved 08 30, 2011, from Protein Structures: tein-domains.html tein-domains.html  …