Institute of Chemical Engineering page 1 Achema 2012 Thermal Process Engineering Process Analytical Technology Unit for Online Verification of the CIP Process in the Pharmaceutical Industry Stefan Pohn Markus Brandstetter Tanja Siegmann-Hegerfeld Michael Harasek Project PATOV

Institute of Chemical Engineering page 2 Achema 2012 Thermal Process Engineering  Actual technologies for measuring the contamination in Cleaning in Place (CIP) waste water are slow (~10min)  The aim is to find a new technology for online verification  Implementing an IR technology (~1 measurement every 1-30s)  Realised within the project PATOV, financed by the 7th Framework Program of the EU Project PATOV

Institute of Chemical Engineering page 3 Achema 2012 Thermal Process Engineering  Experimental CIP plant installed at Vienna University of Technology  Plant is able to reproduce a CIP procedure  Results achieved with the IR equipment are validated with offline TOC (total organic carbon) measurements  PATOV is placed close to the CIP plant to measure the contamination in the CIP process water Project PATOV

Institute of Chemical Engineering page 4 Achema 2012 Thermal Process Engineering  Schematic of experimental CIP plant with PATOV unit Project PATOV

Institute of Chemical Engineering page 5 Achema 2012 Thermal Process Engineering PATOV unit Project PATOV CIP water storage tank Vessel that has to be cleaned Pumps for cycling the water Connection PATOV-CIP system

Institute of Chemical Engineering page 6 Achema 2012 Thermal Process Engineering Actual Status of the Project  At the moment it is possible to make a measurement every second  Down to a concentration of 20ppm  Retention time from the CIP plant to the PATOV unit was brought down to 15s  Only one contaminant can be measured at the moment, the calibration for other contaminants, like proteins is planned Project PATOV

Institute of Chemical Engineering page 7 Achema 2012 Thermal Process Engineering Project Partners Project PATOV Visit