RITONAVIR INTERACTIONS AND SIDE EFFECTS Present by PEERAKARN BANJERDKIJ.

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Presentation transcript:

RITONAVIR INTERACTIONS AND SIDE EFFECTS Present by PEERAKARN BANJERDKIJ

OUTLINE Introduction HIV Therapy Types of HIV-drugs Protease Inhibitors work Ritonavir Pharmacology Drug Interactions Side effects Conclusion

INTRODUCTION Why is the “HIV Therapy” called “multiple therapies”? Ans. : Immune system What is the “medical problem”? Ans. : Drug interactions How many types of HIV-drugs? Ans. : 3 Types

Types of HIV-drugs 2 main groups 1. Reverse Transcriptase 1.1 Nucleoside Reverse Transcriptase Inhibitors (NRTIs) zidovudine (AZT) didanosine (ddI) 1.2 Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs) nevirapine delaviridine 2. Protease Inhibitors (PIs) indinavir ritonavir

What is HIV protease?

How do protease inhibitors work?

How do protease inhibitors differ from other available anti-HIV drugs?

OUTLINE Introduction Ritonavir Pharmacology Drug Interactions Side effects

Pharmacology Block maturation of virus By interfering Act at the stage of HIV replication cycle Produce resistance Bound plasma 98-99% Cross resistance combine with NNRTIs or NRTIs combine with PIs Cross resistance RITONAVIR

OUTLINE Introduction Ritonavir Pharmacology Drug Interactions Side effects

What types of other medications can interact with PIs? Ans.1 : HIV-HIV drugs - Combination Therapy - Double-Drug ; PIs + PIs, PIs + NRTIs - Triple-Drug ; PIs+PIs+NNRTIs Ans.2 : HIV-Other drugs ; PIs+Antivirals Combinations & Interactions RITONAVIR

Drug Interactions Metabolized by P450 at the liver Combine with competition drugs ; can occur 1. Metabolism of these drugs 2. Concentration of Ritonavir and these drugs RITONAVIR

Between Other drugs and Ritonavir DRUG INTERACTION

Between Other drugs and PIs DRUG INTERACTION

Between PIs and PIs * Invirase or Fortovase, + Conducted with Invirase, # with Fortovase DRUG COMBINATION

OUTLINE Introduction Ritonavir Pharmacology Drug Interactions Side effects

Adverse Drug Reaction SIDE EFFECTS

HIV Drugs -Toxicities SIDE EFFECTS

OUTLINE Introduction Ritonavir Pharmacology Drug Interactions Side effects Conclusion

CONCLUSIONS Protease Inhibitors can cure or not! Combination ; more efficiency Side effects ; different ways Resistance Problems Cross resistance problems

THE END THANK YOU Dr. SUVITDr. SUVIT Dr. MARIADr. MARIA Mr. SOMJERDMr. SOMJERD CRI OFFIER & OUR CLASSCRI OFFIER & OUR CLASS……...

Advantages & Disadvantages of Class-Sparing Regimens SIDE EFFECTS