Funding Opportunities at the NIH and the National Institute of Biomedical Imaging and Bioengineering Grace C.Y. Peng, Ph.D. March 19, st annual ORNL Biomedical Science and Engineering Conference

= Institutes and Centers that award grants

Current NIBIB Grant Portfolio Areas Biosensors Biomaterials Biomechanics Biomedical Informatics Drug & Gene Delivery Systems Lab-on-a-Chip Devices/Microsystems Medical Devices & Implant Science Modeling, Simulation and Analysis Nanotechnology Rehabilitation Engineering Surgical Tools & Techniques Telehealth Tissue Engineering Imaging Agents & Molecular Probes Image Displays Image Guided Therapies & Interventions Image Perception Image Processing Magnetic, Biomagnetic & Bioelectric Devices Magnetic Resonance Imaging & Spectroscopy Nuclear Medicine Optical Imaging & Spectroscopy Ultrasound and Acoustics X ray, Electron & Ion Beam

Interagency Modeling and Analysis Group

Multiscale Modeling Multi-scale modeling deals with spanning scales from molecular to population and is expected to largely impact the understanding of biological processes and also further the predictive capability in biological, biomedical and environmental systems. GenesCell structure -function Tissue structure -function Clinical medicine Organ structure -function Proteins Lipids Carbohydrates mRNA … 30,000+ genes 100,000+ proteins 12 organ systems 1 body 200+ cell types 4 tissue types Courtesy of Peter Hunter Biological Scales

Funding Opportunities Google: NIH ARRA – “From the Director”, budget allocations NIH Challenge Grants – RC1 Initiative NIBIB Challenge Grants – institute specific topics Sign up on listservs: Google: NIH Guide Listserv Google: NIBIB updates us: American Recovery and Reinvestment Act of 2009 (ARRA)

BioComputation Challenge Grants Topics Google: imag wiki ( Search: NIH

NIBIB BioComputation Challenge Grant Topics 01-EB-101 – Technologies to Enhance Patient Safety and Avoid Errors in the Clinical Setting 06-EB-109 – Model-Driven Biomedical Technology Development 06-EB-110 – Methods for Assessment of Imaging Technologies 06-EB-111 – Validation of Image Analysis Methods 06-EB-112 – Large-Scale Kinetics of Multiple Signaling Pathways 10-EB-102 – User-Friendly Computing Infrastructures for Biomedical Researchers and Clinicians 15-EB-101 – Towards the Virtual Patient

Funding Opportunity 12 NIH participating institutes 3 years, 9 receipt dates Foreign Institutions are Welcome to Apply!

PAR Objectives To develop multiscale models that link at least two biological scales of modeling and accurately predict biomedical and behavioral processes in health and disease states To develop multiscale models that link at least two biological scales of modeling and accurately predict biomedical and behavioral processes in health and disease states To develop predictive, multiscale models that link to higher levels of the physiome. Models must link to at least one scale beyond molecular interactions at the cellular level (e.g. to cell-cell, cell- environment interactions, as listed above) To develop predictive, multiscale models that link to higher levels of the physiome. Models must link to at least one scale beyond molecular interactions at the cellular level (e.g. to cell-cell, cell- environment interactions, as listed above) To develop predictive, multiscale models that are physiologically mechanistic and have translational potential or clinical applicability To develop predictive, multiscale models that are physiologically mechanistic and have translational potential or clinical applicability To bring together modeling and biomedical expertise to collaborate on building multiscale model(s) To bring together modeling and biomedical expertise to collaborate on building multiscale model(s) To validate and test models with standard datasets To validate and test models with standard datasets To develop models that can be explicitly shared with other modelers To develop models that can be explicitly shared with other modelers

Interagency Modeling and Analysis Group (IMAG)Wiki 10 working groups International New effort

IMAG Multiscale Modeling (MSM) Consortium Working Groups WG1 - Filament Dynamics and Simulation (FDS) WG1 - Filament Dynamics and Simulation (FDS) WG2 - Cardiac and Skeletal Muscle Physiology WG2 - Cardiac and Skeletal Muscle Physiology WG3 - Macro-To-Micro Scale Imaging and Transport in Human Systems WG3 - Macro-To-Micro Scale Imaging and Transport in Human Systems WG4 - Cell Level Modeling WG4 - Cell Level Modeling WG5 - High Performance Computing, Computational Issues and Algorithms WG5 - High Performance Computing, Computational Issues and Algorithms WG6 - Tissue Mechanics WG6 - Tissue Mechanics WG7 - Multiscale Imaging WG7 - Multiscale Imaging WG8 – Theoretical Methods WG8 – Theoretical Methods WG9 – Nano-modeling WG9 – Nano-modeling WG10 – Model Sharing WG10 – Model Sharing